Harald Schwalbe

Harald Schwalbe

Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University

Affiliated withJohann Wolfgang Goethe-UniversityGoethe University Frankfurt

Research Area

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JoVE Journal Publications

ArticleTotal : 2
Year
Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
Publication title

Cited by 7

2021
2021

Other Publications

Article
Year
Disentangling the coil: modulation of conformational and dynamic properties by site-directed mutation in the non-native state of hen egg white lysozyme.

Biochemistry| PubMed ID: 22468860

2012
2012
2003
2003
NMR spectroscopy of RNA.

Chembiochem : a European journal of chemical biology| PubMed ID: 14523911

2003
2004
2004
Modulation of compactness and long-range interactions of unfolded lysozyme by single point mutations.

Angewandte Chemie (International ed. in English)| PubMed ID: 15523735

2004
2005
2005
2005
2005
2005
NMR characterization of kinase p38 dynamics in free and ligand-bound forms.

Angewandte Chemie (International ed. in English)| PubMed ID: 16374788

2006
Photo-CIDNP reveals differences in compaction of non-native states of lysozyme.

Journal of the American Chemical Society| PubMed ID: 16464074

2006
Biomolecular NMR: a chaperone to drug discovery.

Current opinion in chemical biology| PubMed ID: 16679046

2006
2006
2006
Phosphate-group recognition by the aptamer domain of the thiamine pyrophosphate sensing riboswitch.

Chembiochem : a European journal of chemical biology| PubMed ID: 16871614

2006
2007
2007
Structures of RNA switches: insight into molecular recognition and tertiary structure.

Angewandte Chemie (International ed. in English)| PubMed ID: 17226886

2007
2007
Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy.

Chembiochem : a European journal of chemical biology| PubMed ID: 17410622

2007
Time-resolved NMR studies of RNA folding.

Biopolymers| PubMed ID: 17595685

2007
2007
2007
Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 17895388

2007
2008
Conformational dynamics of bistable RNAs studied by time-resolved NMR spectroscopy.

Journal of the American Chemical Society| PubMed ID: 18047344

2007
2008
2008
2008
2009
The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.

The Journal of biological chemistry| PubMed ID: 19073599

2009
2009
2009
Time-resolved NMR spectroscopy: ligand-induced refolding of riboswitches.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 19381559

2009
2009
2009
NMR spectroscopic characterization of the adenine-dependent hairpin ribozyme.

Chembiochem : a European journal of chemical biology| PubMed ID: 19623596

2009
2009
2010
2010
2010
2010
Prion protein amyloid formation involves structural rearrangements in the C-terminal domain.

Chembiochem : a European journal of chemical biology| PubMed ID: 20458726

2010
Probing mechanism and transition state of RNA refolding.

ACS chemical biology| PubMed ID: 20536261

2010
2010
Influence of heparin mimetics on assembly of the FGF.FGFR4 signaling complex.

The Journal of biological chemistry| PubMed ID: 20547770

2010
The molecular mechanism of spider-silk formation.

Angewandte Chemie (International ed. in English)| PubMed ID: 20586091

2010
2010
Folding kinetics for the conformational switch between alternative RNA structures.

The journal of physical chemistry. B| PubMed ID: 20886868

2010
Translation on demand by a simple RNA-based thermosensor.

Nucleic acids research| PubMed ID: 21131278

2011
Engineering encodable lanthanide-binding tags into loop regions of proteins.

Journal of the American Chemical Society| PubMed ID: 21182275

2011
Double take on Piwi protein/piRNA complex structure.

Structure (London, England : 1993)| PubMed ID: 21300281

2011
Characteristics of human lysozyme and its disease-related mutants in their unfolded states.

Angewandte Chemie (International ed. in English)| PubMed ID: 21574221

2011
2011
2011
2011
Mapping the landscape of RNA dynamics with NMR spectroscopy.

Accounts of chemical research| PubMed ID: 21894962

2011
NMR spectroscopic investigations of the activated p38α mitogen-activated protein kinase.

Chembiochem : a European journal of chemical biology| PubMed ID: 22012687

2011
Solution NMR structure of proteorhodopsin.

Angewandte Chemie (International ed. in English)| PubMed ID: 22034093

2011
Time-resolved NMR spectroscopic studies of DNA i-motif folding reveal kinetic partitioning.

Angewandte Chemie (International ed. in English)| PubMed ID: 22095623

2012
Isotope labeling in insect cells.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 22167667

2012
Isotope labeling in mammalian cells.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 22167668

2012
Functional dynamics of RNA ribozymes studied by NMR spectroscopy.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 22315070

2012
2012
Modulation of structure and dynamics by disulfide bond formation in unfolded states.

Journal of the American Chemical Society| PubMed ID: 22414027

2012
2012
2013
2012
2012
2012
NMR studies of HAR1 RNA secondary structures reveal conformational dynamics in the human RNA.

Chembiochem : a European journal of chemical biology| PubMed ID: 22961937

2012
2012
2013
Optimizing the kinetics and thermodynamics of DNA i-motif folding.

Chembiochem : a European journal of chemical biology| PubMed ID: 23794335

2013
Kinase in motion: insights into the dynamic nature of p38α by high-pressure NMR spectroscopic studies.

Chembiochem : a European journal of chemical biology| PubMed ID: 23843149

2013
2013
Detecting intracellular cysteine redox states by in-cell NMR spectroscopy.

Chembiochem : a European journal of chemical biology| PubMed ID: 23893841

2013
RNA refolding studied by light-coupled NMR spectroscopy.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 24136612

2014
2013
Influence of the absolute configuration of npe-caged cytosine on DNA single base pair stability.

Angewandte Chemie (International ed. in English)| PubMed ID: 24339185

2014
2014
2014
2014
2014
2014
2014
2014
2015
2015
2014
Differential scanning fluorimetry for monitoring RNA stability.

Chembiochem : a European journal of chemical biology| PubMed ID: 25867500

2015
2015
2015
Tuning the pH Response of i-Motif DNA Oligonucleotides.

Chembiochem : a European journal of chemical biology| PubMed ID: 26032298

2015
2015
Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy.

Angewandte Chemie (International ed. in English)| PubMed ID: 26136394

2015
Enlightening the photoactive site of channelrhodopsin-2 by DNP-enhanced solid-state NMR spectroscopy.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 26216996

2015
High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.

Acta crystallographica. Section F, Structural biology communications| PubMed ID: 26249705

2015
2015
2015
2015
Influence of Arrestin on the Photodecay of Bovine Rhodopsin.

Angewandte Chemie (International ed. in English)| PubMed ID: 26383645

2015
2016
2016
Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.

Angewandte Chemie (International ed. in English)| PubMed ID: 26805928

2016
2015
2016
Understanding How DNA Enzymes Work.

Angewandte Chemie (International ed. in English)| PubMed ID: 26990154

2016
2016
2016
2016
2016
Terphenyl Derivatives from Allantophomopsis lycopodina.

Journal of natural products| PubMed ID: 27731998

2016
2016
2016
Heteronuclear Cross-Relaxation under Solid-State Dynamic Nuclear Polarization.

Journal of the American Chemical Society| PubMed ID: 27934234

2016
2017
2017
2017
2017
2017
2017
2017
Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.

Chembiochem : a European journal of chemical biology| PubMed ID: 28805284

2017
2017
Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding.

Chembiochem : a European journal of chemical biology| PubMed ID: 28950050

2017
2018
2018
2018
2018
2018
2018
2018
2018
2018
2016
2018
Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 30199112

2018
A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons.

Chembiochem : a European journal of chemical biology| PubMed ID: 30311996

2018
Combined smFRET and NMR analysis of riboswitch structural dynamics.

Methods (San Diego, Calif.)| PubMed ID: 30316819

2019
2018
2019
Solution Structure and Dynamics of the Small Protein HVO_2922 from Haloferax volcanii.

Chembiochem : a European journal of chemical biology| PubMed ID: 31161645

2020
2019
2019
2019
Genetic Code Expansion Facilitates Position-Selective Labeling of RNA for Biophysical Studies.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 31692134

2020
2020
Real-Time NMR Spectroscopy for Studying Metabolism.

Angewandte Chemie (International ed. in English)| PubMed ID: 31730253

2020
Conformational Dynamics of Strand Register Shifts in DNA G-Quadruplexes.

Journal of the American Chemical Society| PubMed ID: 31815451

2020
Structure Validation of G-Rich RNAs in Noncoding Regions of the Human Genome.

Chembiochem : a European journal of chemical biology| PubMed ID: 31943589

2020
A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 31949004

2020
2020
2020
2020
2020
2020
NMR quality control of fragment libraries for screening.

Journal of biomolecular NMR| PubMed ID: 32533387

2020
Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant.

Angewandte Chemie (International ed. in English)| PubMed ID: 32602600

2020
2020
2020
2020
2020
2021
2020
NMR Spectroscopy of Large Functional RNAs: From Sample Preparation to Low-Gamma Detection.

Current protocols in nucleic acid chemistry| PubMed ID: 32960489

2020
2020
Site-specific dynamic nuclear polarization in a Gd(III)-labeled protein.

Physical chemistry chemical physics : PCCP| PubMed ID: 33103678

2020
2020
2020
2021
2020
2021
2020
2021
2021
2021
H, C and N backbone chemical shift assignments of SARS-CoV-2 nsp3a.

Biomolecular NMR assignments| PubMed ID: 33475934

2021
2021
2021
The Folding Landscapes of Human Telomeric RNA and DNA G-Quadruplexes are Markedly Different.

Angewandte Chemie (International ed. in English)| PubMed ID: 33539622

2021
2021
2021
2021
2021
2021
Unraveling the Kinetics of Spare-Tire DNA G-Quadruplex Folding.

Journal of the American Chemical Society| PubMed ID: 33872503

2021
2021
2021
Insights from Binding on Quadruplex Selective Carbazole Ligands.

Chemistry (Weinheim an der Bergstrasse, Germany)| PubMed ID: 34138492

2021
2021
2021
2021
H, C and N assignment of stem-loop SL1 from the 5'-UTR of SARS-CoV-2.

Biomolecular NMR assignments| PubMed ID: 34453696

2021
Oxidative Folding of Proteins: The "Smoking Gun" of Glutathione.

International journal of molecular sciences| PubMed ID: 34576311

2021
2021