Anastassis Perrakis

Oncode Institute and Division of Biochemistry, The Netherlands Cancer Institute

Affiliated withThe Netherlands Cancer Institute The Netherlands Cancer Institute, Amsterdam Netherlands Cancer Institute

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 7	2021
Publication title	2023
Publication title Cited by 1	2021

Other Publications

Article	Year
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nature genetics\| PubMed ID: 12089527
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12598654	2003
Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates. Nucleic acids research\| PubMed ID: 12907723
Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon. Structure (London, England : 1993)\| PubMed ID: 15274918
Towards complete validated models in the next generation of ARP/wARP. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15572775	2004
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. The Journal of biological chemistry\| PubMed ID: 15769751	2005
Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin. The Journal of biological chemistry\| PubMed ID: 15817481	2005
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. The EMBO journal\| PubMed ID: 16710298
Assessment of automatic ligand building in ARP/wARP. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 17164533
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic acids research\| PubMed ID: 17389644
Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease. Nucleic acids research\| PubMed ID: 17626046
ARP/wARP and molecular replacement: the next generation. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 18094467
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell\| PubMed ID: 18155131
A knowledge-driven approach for crystallographic protein model completion. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 18391408
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7. Nature protocols\| PubMed ID: 18600222
Insights into the DNA cleavage mechanism of human LINE-1 retrotransposon endonuclease. Proteins\| PubMed ID: 18767160
"Conditional Restraints": Restraining the Free Atoms in ARP/wARP. Structure (London, England : 1993)\| PubMed ID: 19217389
Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis. Journal of medicinal chemistry\| PubMed ID: 19331415
UV-induced ligand exchange in MHC class I protein crystals. Journal of the American Chemical Society\| PubMed ID: 19655750
Class I major histocompatibility complexes loaded by a periodate trigger. Journal of the American Chemical Society\| PubMed ID: 19655751
Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19667209
Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 20823545
Structural basis of substrate discrimination and integrin binding by autotaxin. Nature structural & molecular biology\| PubMed ID: 21240271
The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1. Nucleic acids research\| PubMed ID: 21415010
Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases. Journal of structural biology\| PubMed ID: 21453775
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. The Journal of biological chemistry\| PubMed ID: 21543332
Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of medicinal chemistry\| PubMed ID: 21615078
Investigating a macromolecular complex: the toolkit of methods. Journal of structural biology\| PubMed ID: 21620973	2011
Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS. Nucleic acids research\| PubMed ID: 21737427
Insights into autotaxin: how to produce and present a lipid mediator. Nature reviews. Molecular cell biology\| PubMed ID: 21915140
Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Molecular cell\| PubMed ID: 21981925
Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank. Bioinformatics (Oxford, England)\| PubMed ID: 22034521	2011
PDB_REDO: constructive validation, more than just looking for errors. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 22505269
Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding. Journal of the American Chemical Society\| PubMed ID: 22775585
Cdt1 and geminin in DNA replication initiation. Sub-cellular biochemistry\| PubMed ID: 22918581
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell\| PubMed ID: 22939620
Structure-function relationships of autotaxin, a secreted lysophospholipase D. Advances in biological regulation\| PubMed ID: 23069371
The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans. The Journal of biological chemistry\| PubMed ID: 23150666
A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B. The Journal of cell biology\| PubMed ID: 23569217	2013
The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. The Journal of biological chemistry\| PubMed ID: 24064211
Timely deposition of macromolecular structures is necessary for peer review. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 24311569
Autotaxin: structure-function and signaling. Journal of lipid research\| PubMed ID: 24548887
The PDB_REDO server for macromolecular structure model optimization. IUCrJ\| PubMed ID: 25075342
The first step of peptide selection in antigen presentation by MHC class I molecules. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25605945
CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling. Science (New York, N.Y.)\| PubMed ID: 26068855
The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 26527144
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nature communications\| PubMed ID: 27075612
Data Mining of Macromolecular Structures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27115630
Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. Journal of structural biology\| PubMed ID: 27268273
Recombinant cloning strategies for protein expression. Current opinion in structural biology\| PubMed ID: 27391134
Editorial overview: New constructs and expression of proteins. Current opinion in structural biology\| PubMed ID: 27520611
Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer cell\| PubMed ID: 27693046
Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase. Proteins\| PubMed ID: 27699881
Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode. Journal of medicinal chemistry\| PubMed ID: 27982588
PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature\| PubMed ID: 28077878
Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. Journal of medicinal chemistry\| PubMed ID: 28165241
Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures. The Journal of biological chemistry\| PubMed ID: 28726638
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. eLife\| PubMed ID: 28849762
Vasohibins encode tubulin detyrosinating activity. Science (New York, N.Y.)\| PubMed ID: 29146869
Homology-based hydrogen bond information improves crystallographic structures in the PDB. Protein science : a publication of the Protein Society\| PubMed ID: 29168245
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish. The international journal of biochemistry & cell biology\| PubMed ID: 29203233
Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nature cell biology\| PubMed ID: 29915359
Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency. The Journal of biological chemistry\| PubMed ID: 30026231
Homology-based loop modeling yields more complete crystallographic protein structures. IUCrJ\| PubMed ID: 30224962
Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation. The Journal of biological chemistry\| PubMed ID: 30381396
Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 30387773
A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop. Proteins\| PubMed ID: 30582207
Direct binding of Cdt2 to PCNA is important for targeting the CRL4 E3 ligase activity to Cdt1. Life science alliance\| PubMed ID: 30623174
Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing. Cell reports\| PubMed ID: 30784592
Building and rebuilding N-glycans in protein structure models. Acta crystallographica. Section D, Structural biology\| PubMed ID: 30988258
Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nature structural & molecular biology\| PubMed ID: 31270470
The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity. The Journal of biological chemistry\| PubMed ID: 31292194
The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions. Cancers\| PubMed ID: 31623219
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation. Journal of cell science\| PubMed ID: 31932507
A Global Ramachandran Score Identifies Protein Structures with Unlikely Stereochemistry. Structure (London, England : 1993)\| PubMed ID: 32857966	2020
Conserved residues Glu37 and Trp229 play an essential role in protein folding of β-lactamase. The FEBS journal\| PubMed ID: 33792206	2021
A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community). F1000Research\| PubMed ID: 32566135	2020
West-Life: A Virtual Research Environment for structural biology. Journal of structural biology: X\| PubMed ID: 32647812	2019
Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein. Analytical biochemistry\| PubMed ID: 32866463	2020
LAHMA: structure analysis through local annotation of homology-matched amino acids. Acta crystallographica. Section D, Structural biology\| PubMed ID: 33404523	2021
Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics. Antimicrobial agents and chemotherapy\| PubMed ID: 34031049	2021
The G132S Mutation Enhances the Resistance of β-Lactamase against Sulbactam. Biochemistry\| PubMed ID: 34250791	2021
CCD: design constructs for protein expression, the easy way. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34342272	2021
New restraints and validation approaches for nucleic acid structures in PDB-REDO. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34473084	2021
Target highlights in CASP14: Analysis of models by structure providers. Proteins\| PubMed ID: 34561912	2021
Imaging Autotaxin with F-Labeled Positron Emission Tomography Ligands. Journal of medicinal chemistry\| PubMed ID: 34662125	2021
AI revolutions in biology: The joys and perils of AlphaFold. EMBO reports\| PubMed ID: 34668287	2021
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8 T cells. Cell reports\| PubMed ID: 34788605	2021
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity. The Journal of biological chemistry\| PubMed ID: 34958798	2022
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants. Nature\| PubMed ID: 35264796	2022
Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. Journal of medicinal chemistry\| PubMed ID: 35440138	2022
Posttranslational modification of microtubules by the MATCAP detyrosinase. Science (New York, N.Y.)\| PubMed ID: 35482892	2022
Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells. Frontiers in pharmacology\| PubMed ID: 35548337	2022
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis. EMBO molecular medicine\| PubMed ID: 35833384	2022
Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants. Nature\| PubMed ID: 35840685	2022
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin. The Journal of cell biology\| PubMed ID: 36107127	2022
Crystal structure of the phospholipase A and acyltransferase 4 (PLAAT4) catalytic domain. Journal of structural biology\| PubMed ID: 36210037	2022
AlphaFill: enriching AlphaFold models with ligands and cofactors. Nature methods\| PubMed ID: 36424442	2023
Autotaxin facilitates selective LPA receptor signaling. Cell chemical biology\| PubMed ID: 36640760	2023

Article	Year
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nature genetics\| PubMed ID: 12089527
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12598654	2003
Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates. Nucleic acids research\| PubMed ID: 12907723
Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon. Structure (London, England : 1993)\| PubMed ID: 15274918
Towards complete validated models in the next generation of ARP/wARP. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15572775	2004
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. The Journal of biological chemistry\| PubMed ID: 15769751	2005
Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin. The Journal of biological chemistry\| PubMed ID: 15817481	2005
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. The EMBO journal\| PubMed ID: 16710298
Assessment of automatic ligand building in ARP/wARP. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 17164533
The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic acids research\| PubMed ID: 17389644
Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease. Nucleic acids research\| PubMed ID: 17626046
ARP/wARP and molecular replacement: the next generation. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 18094467
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell\| PubMed ID: 18155131
A knowledge-driven approach for crystallographic protein model completion. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 18391408
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7. Nature protocols\| PubMed ID: 18600222
Insights into the DNA cleavage mechanism of human LINE-1 retrotransposon endonuclease. Proteins\| PubMed ID: 18767160
"Conditional Restraints": Restraining the Free Atoms in ARP/wARP. Structure (London, England : 1993)\| PubMed ID: 19217389
Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis. Journal of medicinal chemistry\| PubMed ID: 19331415
UV-induced ligand exchange in MHC class I protein crystals. Journal of the American Chemical Society\| PubMed ID: 19655750
Class I major histocompatibility complexes loaded by a periodate trigger. Journal of the American Chemical Society\| PubMed ID: 19655751
Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19667209
Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 20823545
Structural basis of substrate discrimination and integrin binding by autotaxin. Nature structural & molecular biology\| PubMed ID: 21240271
The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1. Nucleic acids research\| PubMed ID: 21415010
Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases. Journal of structural biology\| PubMed ID: 21453775
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. The Journal of biological chemistry\| PubMed ID: 21543332
Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of medicinal chemistry\| PubMed ID: 21615078
Investigating a macromolecular complex: the toolkit of methods. Journal of structural biology\| PubMed ID: 21620973	2011
Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS. Nucleic acids research\| PubMed ID: 21737427
Insights into autotaxin: how to produce and present a lipid mediator. Nature reviews. Molecular cell biology\| PubMed ID: 21915140
Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Molecular cell\| PubMed ID: 21981925
Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank. Bioinformatics (Oxford, England)\| PubMed ID: 22034521	2011
PDB_REDO: constructive validation, more than just looking for errors. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 22505269
Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding. Journal of the American Chemical Society\| PubMed ID: 22775585
Cdt1 and geminin in DNA replication initiation. Sub-cellular biochemistry\| PubMed ID: 22918581
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell\| PubMed ID: 22939620
Structure-function relationships of autotaxin, a secreted lysophospholipase D. Advances in biological regulation\| PubMed ID: 23069371
The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans. The Journal of biological chemistry\| PubMed ID: 23150666
A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B. The Journal of cell biology\| PubMed ID: 23569217	2013
The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing. The Journal of biological chemistry\| PubMed ID: 24064211
Timely deposition of macromolecular structures is necessary for peer review. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 24311569
Autotaxin: structure-function and signaling. Journal of lipid research\| PubMed ID: 24548887
The PDB_REDO server for macromolecular structure model optimization. IUCrJ\| PubMed ID: 25075342
The first step of peptide selection in antigen presentation by MHC class I molecules. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25605945
CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling. Science (New York, N.Y.)\| PubMed ID: 26068855
The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 26527144
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nature communications\| PubMed ID: 27075612
Data Mining of Macromolecular Structures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27115630
Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. Journal of structural biology\| PubMed ID: 27268273
Recombinant cloning strategies for protein expression. Current opinion in structural biology\| PubMed ID: 27391134
Editorial overview: New constructs and expression of proteins. Current opinion in structural biology\| PubMed ID: 27520611
Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer cell\| PubMed ID: 27693046
Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase. Proteins\| PubMed ID: 27699881
Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode. Journal of medicinal chemistry\| PubMed ID: 27982588
PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature\| PubMed ID: 28077878
Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. Journal of medicinal chemistry\| PubMed ID: 28165241
Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures. The Journal of biological chemistry\| PubMed ID: 28726638
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. eLife\| PubMed ID: 28849762
Vasohibins encode tubulin detyrosinating activity. Science (New York, N.Y.)\| PubMed ID: 29146869
Homology-based hydrogen bond information improves crystallographic structures in the PDB. Protein science : a publication of the Protein Society\| PubMed ID: 29168245
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish. The international journal of biochemistry & cell biology\| PubMed ID: 29203233
Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nature cell biology\| PubMed ID: 29915359
Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency. The Journal of biological chemistry\| PubMed ID: 30026231
Homology-based loop modeling yields more complete crystallographic protein structures. IUCrJ\| PubMed ID: 30224962
Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation. The Journal of biological chemistry\| PubMed ID: 30381396
Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 30387773
A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop. Proteins\| PubMed ID: 30582207
Direct binding of Cdt2 to PCNA is important for targeting the CRL4 E3 ligase activity to Cdt1. Life science alliance\| PubMed ID: 30623174
Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing. Cell reports\| PubMed ID: 30784592
Building and rebuilding N-glycans in protein structure models. Acta crystallographica. Section D, Structural biology\| PubMed ID: 30988258
Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nature structural & molecular biology\| PubMed ID: 31270470
The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity. The Journal of biological chemistry\| PubMed ID: 31292194
The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions. Cancers\| PubMed ID: 31623219
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation. Journal of cell science\| PubMed ID: 31932507
A Global Ramachandran Score Identifies Protein Structures with Unlikely Stereochemistry. Structure (London, England : 1993)\| PubMed ID: 32857966	2020
Conserved residues Glu37 and Trp229 play an essential role in protein folding of β-lactamase. The FEBS journal\| PubMed ID: 33792206	2021
A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community). F1000Research\| PubMed ID: 32566135	2020
West-Life: A Virtual Research Environment for structural biology. Journal of structural biology: X\| PubMed ID: 32647812	2019
Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein. Analytical biochemistry\| PubMed ID: 32866463	2020
LAHMA: structure analysis through local annotation of homology-matched amino acids. Acta crystallographica. Section D, Structural biology\| PubMed ID: 33404523	2021
Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics. Antimicrobial agents and chemotherapy\| PubMed ID: 34031049	2021
The G132S Mutation Enhances the Resistance of β-Lactamase against Sulbactam. Biochemistry\| PubMed ID: 34250791	2021
CCD: design constructs for protein expression, the easy way. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34342272	2021
New restraints and validation approaches for nucleic acid structures in PDB-REDO. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34473084	2021
Target highlights in CASP14: Analysis of models by structure providers. Proteins\| PubMed ID: 34561912	2021
Imaging Autotaxin with F-Labeled Positron Emission Tomography Ligands. Journal of medicinal chemistry\| PubMed ID: 34662125	2021
AI revolutions in biology: The joys and perils of AlphaFold. EMBO reports\| PubMed ID: 34668287	2021
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8 T cells. Cell reports\| PubMed ID: 34788605	2021
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity. The Journal of biological chemistry\| PubMed ID: 34958798	2022
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants. Nature\| PubMed ID: 35264796	2022
Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. Journal of medicinal chemistry\| PubMed ID: 35440138	2022
Posttranslational modification of microtubules by the MATCAP detyrosinase. Science (New York, N.Y.)\| PubMed ID: 35482892	2022
Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells. Frontiers in pharmacology\| PubMed ID: 35548337	2022
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis. EMBO molecular medicine\| PubMed ID: 35833384	2022
Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants. Nature\| PubMed ID: 35840685	2022
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin. The Journal of cell biology\| PubMed ID: 36107127	2022
Crystal structure of the phospholipase A and acyltransferase 4 (PLAAT4) catalytic domain. Journal of structural biology\| PubMed ID: 36210037	2022
AlphaFill: enriching AlphaFold models with ligands and cofactors. Nature methods\| PubMed ID: 36424442	2023
Autotaxin facilitates selective LPA receptor signaling. Cell chemical biology\| PubMed ID: 36640760	2023