Zora Modrusan

Department of Microchemistry, Genentech

Affiliated withGenentech

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2022

Other Publications

Article	Year
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Developmental biology\| PubMed ID: 16360140	2006
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16361555	2005
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer cell\| PubMed ID: 16530701	2006
Regulation of ERK3/MAPK6 expression by BRAF. International journal of oncology\| PubMed ID: 16964379	2006
The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17277128	2007
Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis. Differentiation; research in biological diversity\| PubMed ID: 17288544	2007
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360667	2007
Molecular signatures define two main classes of meningiomas. Molecular cancer\| PubMed ID: 17937814	2007
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nature medicine\| PubMed ID: 18264109	2008
Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18322195	2008
Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer research\| PubMed ID: 18593940	2008
Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake. Molecular cancer therapeutics\| PubMed ID: 18790743	2008
Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18794102	2008
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer cell\| PubMed ID: 19111878	2009
Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathwa... Cancer research\| PubMed ID: 19276360	2009
Microarray analysis of RNA extracted from formalin-fixed, paraffin-embedded and matched fresh-frozen ovarian adenocarcinomas. BMC medical genomics\| PubMed ID: 19426511	2009
Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus. PloS one\| PubMed ID: 19568420	2009
Oncogenic activating mutations are associated with local copy gain. Molecular cancer research : MCR\| PubMed ID: 19671679	2009
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Molecular cancer research : MCR\| PubMed ID: 19737969	2009
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer cell\| PubMed ID: 19962665	2009
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer cell\| PubMed ID: 20385361	2010
The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature\| PubMed ID: 20505728	2010
Diverse somatic mutation patterns and pathway alterations in human cancers. Nature\| PubMed ID: 20668451	2010
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21081700	2010
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer research\| PubMed ID: 21123452	2011
Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21187436	2011
Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples. BMC medical genomics\| PubMed ID: 21261984	2011
CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma. Science translational medicine\| PubMed ID: 21411738	2011
Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21597001	2011
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. The Journal of cell biology\| PubMed ID: 21606205	2011
TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Science signaling\| PubMed ID: 21673316	2011
Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model. The American journal of pathology\| PubMed ID: 21819959	2011
miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer. Science signaling\| PubMed ID: 21868360	2011
A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21949371	2011
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nature immunology\| PubMed ID: 21993848	2011
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 22025148	2011
Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer research\| PubMed ID: 22108827	2012
DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22261801	2012
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome research\| PubMed ID: 22267523	2012
Death receptors DR6 and TROY regulate brain vascular development. Developmental cell\| PubMed ID: 22340501	2012
CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency. Cancer research\| PubMed ID: 22345154	2012
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. The EMBO journal\| PubMed ID: 22773185	2012
Loss of the tumor suppressor BAP1 causes myeloid transformation. Science (New York, N.Y.)\| PubMed ID: 22878500	2012
Recurrent R-spondin fusions in colon cancer. Nature\| PubMed ID: 22895193	2012
Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation. The Journal of allergy and clinical immunology\| PubMed ID: 22920495	2012
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nature genetics\| PubMed ID: 22941189	2012
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome research\| PubMed ID: 23033341	2012
Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines. The Journal of biological chemistry\| PubMed ID: 23188824	2013
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23431164	2013
A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation. The Biochemical journal\| PubMed ID: 23496764	2013
Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model. PloS one\| PubMed ID: 23520493	2013
Oncogenic ERBB3 mutations in human cancers. Cancer cell\| PubMed ID: 23680147	2013
Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23685835	2013
Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages. Immunology and cell biology\| PubMed ID: 23817579	2013
Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability. The Journal of biological chemistry\| PubMed ID: 23897821	2013
Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control. BMC genomics\| PubMed ID: 24059244	2013
Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nature immunology\| PubMed ID: 24141388	2013
NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Nature\| PubMed ID: 24739962	2014
Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer research\| PubMed ID: 24755469	2014
An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth. Genes & development\| PubMed ID: 24788092	2014
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. Nature communications\| PubMed ID: 24807215	2014
Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24879793	2014
Diverse modes of genomic alteration in hepatocellular carcinoma. Genome biology\| PubMed ID: 25159915	2014
Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax\| PubMed ID: 25217476	2015
Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25392500	2014
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. Nature genetics\| PubMed ID: 25401301	2015
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature\| PubMed ID: 25428506	2014
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature\| PubMed ID: 25470037	2015
A comprehensive transcriptional portrait of human cancer cell lines. Nature biotechnology\| PubMed ID: 25485619	2015
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. Cancer cell\| PubMed ID: 25759019	2015
IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells. The Journal of allergy and clinical immunology\| PubMed ID: 25784274	2015
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1. Cell\| PubMed ID: 26627735	2015
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nature genetics\| PubMed ID: 26928227	2016
Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses. Nature communications\| PubMed ID: 27097852	2016
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase. mBio\| PubMed ID: 27601569	2016
Building proteomic tool boxes to monitor MHC class I and class II peptides. Proteomics\| PubMed ID: 27928884	2017
A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action. Nature communications\| PubMed ID: 28102191	2017
A distinct role for Lgr5 stem cells in primary and metastatic colon cancer. Nature\| PubMed ID: 28358093	2017
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. Scientific reports\| PubMed ID: 28361918	2017
Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFN-driven lupus nephritis. JCI insight\| PubMed ID: 28405610	2017
The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation. Science signaling\| PubMed ID: 28420753	2017
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult. eLife\| PubMed ID: 28440222	2017
Stem cell plasticity enables hair regeneration following Lgr5 cell loss. Nature cell biology\| PubMed ID: 28553937	2017
Massively parallel nanowell-based single-cell gene expression profiling. BMC genomics\| PubMed ID: 28687070	2017
Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity. NPJ systems biology and applications\| PubMed ID: 28725461	2015
Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation. The Journal of experimental medicine\| PubMed ID: 28778989	2017
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Science translational medicine\| PubMed ID: 28814543	2017
Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer. Cancer research\| PubMed ID: 28819026	2017
Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia. The Journal of cell biology\| PubMed ID: 28887438	2017
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins. eLife\| PubMed ID: 28933694	2017
Host-derived fatty acids activate type VII secretion in . Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28973946	2017
PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29087303	2017
mutant genetically engineered mouse models of human cancers are genomically heterogeneous. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29203670	2017
SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer. The Journal of cell biology\| PubMed ID: 29229751	2018
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nature communications\| PubMed ID: 29330524	2018
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models. Cell reports\| PubMed ID: 29346778	2018
Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. eLife\| PubMed ID: 29402381	2018
Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India. BMC medical genetics\| PubMed ID: 29439679	2018
Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer. PloS one\| PubMed ID: 29596465	2018
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nature chemical biology\| PubMed ID: 29632413	2018
Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes. Science immunology\| PubMed ID: 29678836	2018
Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nature chemical biology\| PubMed ID: 29728602	2018
ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 29760222	2018
CRISPR off-target analysis in genetically engineered rats and mice. Nature methods\| PubMed ID: 29786090	2018
Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis. Annals of the rheumatic diseases\| PubMed ID: 29853453	2018
An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors. Cancer discovery\| PubMed ID: 29884728	2018
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma. Pigment cell & melanoma research\| PubMed ID: 30156010	2019
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30322923	2018
Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation. Cell death and differentiation\| PubMed ID: 30824837	2019
Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation. Cell reports\| PubMed ID: 30943407	2019
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification. PloS one\| PubMed ID: 30951545	2019
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science (New York, N.Y.)\| PubMed ID: 31000662	2019
A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31004000	2019
Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8 T Cells in Murine Syngeneic Tumor Models. Cancer immunology research\| PubMed ID: 31064777	2019
IRF2 transcriptionally induces expression for pyroptosis. Science signaling\| PubMed ID: 31113851	2019
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma. eLife\| PubMed ID: 31144617	2019
Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy. Scientific reports\| PubMed ID: 31222070	2019
SCINA: A Semi-Supervised Subtyping Algorithm of Single Cells and Bulk Samples. Genes\| PubMed ID: 31336988	2019
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility. Cell\| PubMed ID: 31353221	2019
An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Nature immunology\| PubMed ID: 31406377	2019
Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies. Communications biology\| PubMed ID: 31428692	2019
CD3 bispecific antibody-induced cytokine release is dispensable for cytotoxic T cell activity. Science translational medicine\| PubMed ID: 31484792	2019
Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15 Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy. Cancer discovery\| PubMed ID: 31699795	2020
Activity of caspase-8 determines plasticity between cell death pathways. Nature\| PubMed ID: 31723262	2019
S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis. Breast cancer research : BCR\| PubMed ID: 31881983	2019
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins. Nature genetics\| PubMed ID: 31907489	2020
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 31980586	2020
Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration. Cell reports\| PubMed ID: 31995762	2020
Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal. Cell reports\| PubMed ID: 32023464	2020
Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires. mAbs\| PubMed ID: 32041466	2020
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP. Immunity\| PubMed ID: 32049051	2020
Peripheral T cell expansion predicts tumour infiltration and clinical response. Nature\| PubMed ID: 32103181	2020
IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment. Cancer research\| PubMed ID: 32265225	2020
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas. Nature communications\| PubMed ID: 32345963	2020
High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade. Nature medicine\| PubMed ID: 32405063	2020
Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. Cell reports\| PubMed ID: 32610143	2020
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 32651223	2020
Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32759214	2020
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia. Cell\| PubMed ID: 32795415	2020
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate. Nature communications\| PubMed ID: 32839463	2020
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase. mBio\| PubMed ID: 32900806	2020
Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 33023953	2021
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients. Nature communications\| PubMed ID: 33144586	2020
Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways. Cancer discovery\| PubMed ID: 33208393	2021
Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis. Cell reports. Medicine\| PubMed ID: 33294861	2020
The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models. PloS one\| PubMed ID: 33444326	2021
NINJ1 mediates plasma membrane rupture during lytic cell death. Nature\| PubMed ID: 33472215	2021
Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade. Nature medicine\| PubMed ID: 33547461	2021
Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase-mediated cassette... Biotechnology progress\| PubMed ID: 33666334	2021
Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination. Cell reports\| PubMed ID: 33691116	2021
Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population. JCI insight\| PubMed ID: 33705361	2021
Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells. eLife\| PubMed ID: 33724181	2021
Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade. Journal for immunotherapy of cancer\| PubMed ID: 33827905	2021
Gremlin 1 fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues. Nature immunology\| PubMed ID: 33903764	2021
ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. Nature\| PubMed ID: 33953400	2021
Cross-tissue organization of the fibroblast lineage. Nature\| PubMed ID: 33981032	2021
Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1. Immunity\| PubMed ID: 34260887	2021
ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses. The Journal of experimental medicine\| PubMed ID: 34297039	2021
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis. Science translational medicine\| PubMed ID: 34349032	2021
Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease. Cell reports. Medicine\| PubMed ID: 34467254	2021
Identifying transcriptional programs underlying cancer drug response with TraCe-seq. Nature biotechnology\| PubMed ID: 34531539	2022
Determinants of renal cell carcinoma invasion and metastatic competence. Nature communications\| PubMed ID: 34608135	2021
A renal cell carcinoma tumorgraft platform to advance precision medicine. Cell reports\| PubMed ID: 34818533	2021
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nature communications\| PubMed ID: 34911951	2021
TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease. Cell reports\| PubMed ID: 34965428	2021
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma. Science translational medicine\| PubMed ID: 35020406	2022
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity. Nature immunology\| PubMed ID: 35314846	2022
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors. Nature communications\| PubMed ID: 35440108	2022
Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma. Science translational medicine\| PubMed ID: 35442706	2022
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation. The Journal of cell biology\| PubMed ID: 35446348	2022
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma. The Journal of allergy and clinical immunology\| PubMed ID: 35487308	2022
Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 35675956	2022