Patrick A. Lewis

Department of Molecular Neuroscience, UCL Institute of Neurology

Affiliated withUCL Institute of Neurology University of Reading

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2012
Publication title Cited by 11	2018

Other Publications

Article	Year
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiology of disease\| PubMed ID: 11895378	2002
Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity. The Biochemical journal\| PubMed ID: 16441239	2006
Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation. The Journal of general virology\| PubMed ID: 16847141	2006
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. Journal of neurochemistry\| PubMed ID: 17394548	2007
The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochemical and biophysical research communications\| PubMed ID: 17442267	2007
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17913923	2007
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18230735	2008
Genetic neuropathology of Parkinson's disease. International journal of clinical and experimental pathology\| PubMed ID: 18784814	2008
Emerging pathways in genetic Parkinson's disease. The FEBS journal\| PubMed ID: 19021751	2008
Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. The FEBS journal\| PubMed ID: 19021752	2008
The function of ROCO proteins in health and disease. Biology of the cell / under the auspices of the European Cell Biology Organization\| PubMed ID: 19152505	2009
The R1441C mutation alters the folding properties of the ROC domain of LRRK2. Biochimica et biophysica acta\| PubMed ID: 19781641	2009
Cancer and neurodegeneration: between the devil and the deep blue sea. PLoS genetics\| PubMed ID: 21203498	2010
A tangled web - tau and sporadic Parkinson's disease. Frontiers in psychiatry / Frontiers Research Foundation\| PubMed ID: 21423457	2010
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue. PloS one\| PubMed ID: 21799870	2011
Parkinson's disease induced pluripotent stem cells with triplication of the Î±-synuclein locus. Nature communications\| PubMed ID: 21863007	2011
Gene expression in the Parkinson's disease brain. Brain research bulletin\| PubMed ID: 22173063	2011
LRRK2 and Human Disease: A Complicated Question or a Question of Complexes? Science signaling\| PubMed ID: 22253261	2012
Correction: Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue. PloS one\| PubMed ID: 22303433	2012
GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1. Scientific reports\| PubMed ID: 23019516	2012
α-Synuclein mutations cluster around a putative protein loop. Neuroscience letters\| PubMed ID: 23669636	2013
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23682122	2013
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases. Neurobiology of disease\| PubMed ID: 23747310	2013
Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochimica et biophysica acta\| PubMed ID: 23916833	2013
LRRK2: cause, risk, and mechanism. Journal of Parkinson's disease\| PubMed ID: 23938341	2013
Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. PloS one\| PubMed ID: 23967090	2013
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochemical and biophysical research communications\| PubMed ID: 24211199	2013
Rare variants in LRRK1 and Parkinson's disease. Neurogenetics\| PubMed ID: 24241507	2014
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Human molecular genetics\| PubMed ID: 24740878	2014
Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. The Journal of biological chemistry\| PubMed ID: 24942733	2014
Genetic, structural, and molecular insights into the function of ras of complex proteins domains. Chemistry & biology\| PubMed ID: 24981771	2014
Computational analysis of the LRRK2 interactome. PeerJ\| PubMed ID: 25737818	2015
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Molecular neurodegeneration\| PubMed ID: 26306801	2015
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. Journal of neurochemistry\| PubMed ID: 26375402	2015
Parkinson's disease: From human genetics to clinical trials. Science translational medicine\| PubMed ID: 26378242	2015
Genetic and phenotypic characterization of complex hereditary spastic paraplegia. Brain : a journal of neurology\| PubMed ID: 27217339	2016
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Scientific reports\| PubMed ID: 27731364	2016
Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance. Human molecular genetics\| PubMed ID: 27798102	2016
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences. Briefings in bioinformatics\| PubMed ID: 27881428	2018
Weighted Protein Interaction Network Analysis of Frontotemporal Dementia. Journal of proteome research\| PubMed ID: 28004582	2017
LRRK2 and Autophagy. Advances in neurobiology\| PubMed ID: 28353280	2017
Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3. Neurogenetics\| PubMed ID: 28391543	2017
Leucine Rich Repeat Kinase 2: beyond Parkinson's and beyond kinase inhibitors. Expert opinion on therapeutic targets\| PubMed ID: 28609155	2017
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS medicine\| PubMed ID: 28609445	2017
The LRRK2 signalling system. Cell and tissue research\| PubMed ID: 29308544	2018
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2. Frontiers in molecular neuroscience\| PubMed ID: 29311810	2017
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Proteomics\| PubMed ID: 29513927	2018
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition. Bioscience reports\| PubMed ID: 29563162	2018
Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis. Acta neuropathologica\| PubMed ID: 29600398	2018
LRRK2 is a negative regulator of phagosome maturation in macrophages. The EMBO journal\| PubMed ID: 29789389	2018
Stratification of candidate genes for Parkinson's disease using weighted protein-protein interaction network analysis. BMC genomics\| PubMed ID: 29898659	2018
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology. Brain research\| PubMed ID: 30055128	2018