Alessandro Prigione

Alessandro Prigione is a tenured Associate Professor of Pediatric Metabolic Medicine at the Department of General Pediatrics, Neonatology and Pediatric Cardiology at Heinrich Heine University (HHU) in Düsseldorf Germany.

The interest of the Prigione group is to develop induced pluripotent stem cells (iPSC)-based approaches for disease modeling and drug discovery of rare incurable neurological and neurodevelopmental disorders affecting mitochondrial metabolism. A specific focus is on Leigh syndrome, which is the most severe mitochondrial disease affecting children. His laboratory employs human neurons and brain organoids from patients with Leigh syndrome to dissect the neuronal-specific disease mechanisms to possibly identify novel disease targets and interventions.