Davide Trotti

Jefferson Weinberg ALS Center, Thomas Jefferson University

Affiliated withThomas Jefferson University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2021

Other Publications

Article	Year
A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. The Journal of biological chemistry\| PubMed ID: 17823119	2007
Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis. Experimental neurology\| PubMed ID: 18625223	2008
Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxidants & redox signaling\| PubMed ID: 19413484	2009
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. Human molecular genetics\| PubMed ID: 20460269	2010
Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria. The Journal of biological chemistry\| PubMed ID: 20551319	2010
Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia\| PubMed ID: 21769946	2011
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22416121	2012
Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS. Neurobiology of disease\| PubMed ID: 22521463	2012
Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23843527	2013
Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis. Neuromolecular medicine\| PubMed ID: 24062161	2013
Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis. Biochimica et biophysica acta\| PubMed ID: 24568860	2014
ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. Brain research\| PubMed ID: 25175835	2015
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron\| PubMed ID: 25521377
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Annals of clinical and translational neurology\| PubMed ID: 25574474	2014
Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders. Brain research\| PubMed ID: 26187753	2015
Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotroph... Glia\| PubMed ID: 27158936	2016
Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. Neuroscience letters\| PubMed ID: 27619540	2017
Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD. Cell reports\| PubMed ID: 27732842	2016
Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Experimental neurology\| PubMed ID: 28342750	2017
Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies. The AAPS journal\| PubMed ID: 28779378	2017
EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis. Advances in neurobiology\| PubMed ID: 28828608	2017
Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha. Glia\| PubMed ID: 29380416
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature medicine\| PubMed ID: 29400714	2018
miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 29773756	2018
Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO molecular medicine\| PubMed ID: 30617154	2019
Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis. Experimental neurology\| PubMed ID: 30974102	2019
Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. EMBO molecular medicine\| PubMed ID: 32347002	2020
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis. The EMBO journal\| PubMed ID: 33792056	2021