Keith M. Channon

BHF Centre of Research Excellence, University of Oxford

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2022

Other Publications

Article	Year
Coronary artery aneurysm rupture mimicking dissection of the thoracic aorta. International journal of cardiology\| PubMed ID: 9699940	1998
Giant coronary artery aneurysm presenting as a mediastinal mass. The American journal of cardiology\| PubMed ID: 9832118	1998
Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 10938006	2000
Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society\| PubMed ID: 12512689	2002
Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. The Journal of clinical investigation\| PubMed ID: 12952921	2003
Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. Trends in cardiovascular medicine\| PubMed ID: 15596110	2004
Radiochemical HPLC detection of arginine metabolism: measurement of nitric oxide synthesis and arginase activity in vascular tissue. Nitric oxide : biology and chemistry\| PubMed ID: 16647284	2007
Functional and structural vascular remodeling in elite rowers assessed by cardiovascular magnetic resonance. Journal of the American College of Cardiology\| PubMed ID: 16904551	2006
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitr... Circulation\| PubMed ID: 16940192	2006
Membrane-bound CC chemokine inhibitor 35K provides localized inhibition of CC chemokine activity in vitro and in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17015744	2006
Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17204666	2007
Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 17210833	2007
Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circulation research\| PubMed ID: 17363703	2007
Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation\| PubMed ID: 17420345	2007
Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus. Diabetes & vascular disease research\| PubMed ID: 17469043	2007
Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection. The journal of gene medicine\| PubMed ID: 17471590	2007
Effect of distal embolization on myocardial perfusion reserve after percutaneous coronary intervention: a quantitative magnetic resonance perfusion study. Circulation\| PubMed ID: 17785626	2007
In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide. Nature medicine\| PubMed ID: 17891147	2007
Images in cardiovascular medicine. Optical coherence tomography in the setting of an acute anterior myocardial infarction. Circulation\| PubMed ID: 17909111	2007
Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17962629	2008
Early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imaging. Atherosclerosis\| PubMed ID: 17977546	2008
Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation. Circulation\| PubMed ID: 18040031	2007
Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 18096829	2008
Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 18275595	2008
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Current biology : CB\| PubMed ID: 18328704	2008
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Molecular and cellular biology\| PubMed ID: 18332118	2008
A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL. Atherosclerosis\| PubMed ID: 18367190	2008
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation\| PubMed ID: 18474817	2008
Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIa. Journal of vascular research\| PubMed ID: 18515970	2009
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Journal of the American College of Cardiology\| PubMed ID: 18598896	2008
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis. Circulation\| PubMed ID: 18824773	2008
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with... The Journal of biological chemistry\| PubMed ID: 19011239	2009
The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons. The European journal of neuroscience\| PubMed ID: 19032594	2008
Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting. The American journal of cardiology\| PubMed ID: 19121439	2009
Targeting redox signaling in the vascular wall: from basic science to clinical practice. Current pharmaceutical design\| PubMed ID: 19149622	2009
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression. The Journal of biological chemistry\| PubMed ID: 19286659	2009
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial functio... European heart journal\| PubMed ID: 19297385	2009
L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats. Journal of molecular and cellular cardiology\| PubMed ID: 19362092	2009
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atheroscleros... Circulation\| PubMed ID: 19398669	2009
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis... The Journal of biological chemistry\| PubMed ID: 19666465	2009
Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery. Circulation\| PubMed ID: 19752364	2009
Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. Journal of molecular and cellular cardiology\| PubMed ID: 19766235	2009
Reproducibility and accuracy of automated measurement for dynamic arterial lumen area by cardiovascular magnetic resonance. The international journal of cardiovascular imaging\| PubMed ID: 19779977	2009
Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study. Journal of the American College of Cardiology\| PubMed ID: 19874992	2009
Intimal dissection causing late thrombosis of a covered stent: optical coherence tomography appearances. Circulation. Cardiovascular interventions\| PubMed ID: 20031740	2009
Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20185690	2010
Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications. Clinical science (London, England : 1979)\| PubMed ID: 20210786	2010
Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20418482	2010
Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology. Heart (British Cardiac Society)\| PubMed ID: 20837663	2010
Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation\| PubMed ID: 20837928	2010
GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 21059996	2010
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. Free radical biology & medicine\| PubMed ID: 21402147	2011
Dynamic changes of edema and late gadolinium enhancement after acute myocardial infarction and their relationship to functional recovery and salvage index. Circulation. Cardiovascular imaging\| PubMed ID: 21447711	2011
Optical coherence tomography-guided stenting of a large coronary aneurysm: images at implantation and at 6 months. The Journal of invasive cardiology\| PubMed ID: 21474852	2011
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric oxide : biology and chemistry\| PubMed ID: 21550412	2011
Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade. Molecular pharmacology\| PubMed ID: 21586597	2011
Radial artery graft string sign due to lumen obliteration by neointima: insight from optical coherence tomography. JACC. Cardiovascular interventions\| PubMed ID: 21596334	2011
Loss of NRF2 impairs gastric nitrergic stimulation and function. Free radical biology & medicine\| PubMed ID: 21605664	2011
Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure. Journal of molecular and cellular cardiology\| PubMed ID: 21645517	2011
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes\| PubMed ID: 21677284	2011
Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase... Circulation\| PubMed ID: 21730307	2011
OCT characteristics of saphenous vein graft atherosclerosis. JACC. Cardiovascular imaging\| PubMed ID: 21757173	2011
Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins. Circulation\| PubMed ID: 21844076	2011
Treatment of recurrent vein graft "stent-in-stent" re-stenosis guided by optical coherence tomography. International journal of cardiology\| PubMed ID: 21880385	2012
Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis. Circulation\| PubMed ID: 21969008	2011
Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: relationships with coronary disease se... Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 22017860	2011
Therapeutic strategies targeting endothelial function in humans: clinical implications. Current vascular pharmacology\| PubMed ID: 22112349	2012
Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. Journal of the American College of Cardiology\| PubMed ID: 22192670	2012
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin. Cardiovascular research\| PubMed ID: 22241166	2012
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice. Cardiovascular research\| PubMed ID: 22287576	2012
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. Circulation\| PubMed ID: 22315282	2012
Statins and vein graft failure in coronary bypass surgery. Current opinion in pharmacology\| PubMed ID: 22326889	2012
Lines of Zahn in coronary artery thrombus. European heart journal\| PubMed ID: 22345124	2012
A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22499989	2012
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes\| PubMed ID: 22733797	2012
Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation. Circulation research\| PubMed ID: 22798524	2012
Angiogenesis in the infarcted myocardium. Antioxidants & redox signaling\| PubMed ID: 22870932	2013
Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification. European heart journal\| PubMed ID: 23008511	2012
The role of tetrahydrobiopterin in inflammation and cardiovascular disease. Thrombosis and haemostasis\| PubMed ID: 23052970	2012
Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling. The Journal of biological chemistry\| PubMed ID: 23139420	2013
Tetrahydrobiopterin: a vascular redox target to improve endothelial function. Current vascular pharmacology\| PubMed ID: 23259560	2012
Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice. Circulation research\| PubMed ID: 23325497	2013
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes\| PubMed ID: 23349484	2013
Relationship of plasma neuropeptide Y with angiographic, electrocardiographic and coronary physiology indices of reperfusion during ST elevation myocardial infarction. Heart (British Cardiac Society)\| PubMed ID: 23403409	2013
A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages. PloS one\| PubMed ID: 23516549	2013
Artifactual elevation of plasma sCD40L by residual platelets in patients with coronary artery disease. International journal of cardiology\| PubMed ID: 23578897	2013
Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23620395	2013
Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation\| PubMed ID: 23625959	2013
The downstream regulation of chemokine receptor signalling: implications for atherosclerosis. Mediators of inflammation\| PubMed ID: 23690662	2013
A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization. The Journal of biological chemistry\| PubMed ID: 23965989	2013
Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration. Circulation\| PubMed ID: 24030421	2013
Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering. Antioxidants & redox signaling\| PubMed ID: 24111702	2014
Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction. European heart journal\| PubMed ID: 24135835	2014
A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia. American journal of hematology\| PubMed ID: 24136375	2014
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free radical biology & medicine\| PubMed ID: 24148766	2014
Tetrahydrobiopterin in cardiovascular health and disease. Antioxidants & redox signaling\| PubMed ID: 24294830	2014
Statins: pleiotropic regulators of cardiovascular redox state. Antioxidants & redox signaling\| PubMed ID: 24409984	2014
GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 24644242	2014
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 24777984	2014
Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. Circulation\| PubMed ID: 24807872	2014
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo. Blood\| PubMed ID: 25030063	2014
Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock. Shock (Augusta, Ga.)\| PubMed ID: 25046538	2014
Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25060790	2014
Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 25077938	2014
Fractalkine promotes human monocyte survival via a reduction in oxidative stress. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25359863	2014
Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation. PloS one\| PubMed ID: 25389974	2014
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain : a journal of neurology\| PubMed ID: 25398233	2015
Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarc... Journal of the American College of Cardiology\| PubMed ID: 25444143	2014
Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation. Free radical biology & medicine\| PubMed ID: 25451639	2015
Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue. Diabetes\| PubMed ID: 25552596	2015
A requirement for Gch1 and tetrahydrobiopterin in embryonic development. Developmental biology\| PubMed ID: 25557619	2015
Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat. Pulmonary circulation\| PubMed ID: 25621160	2014
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25675482	2015
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nature communications\| PubMed ID: 25782711	2015
A Randomized Trial of External Stenting for Saphenous Vein Grafts in Coronary Artery Bypass Grafting. The Annals of thoracic surgery\| PubMed ID: 25886810	2015
Redox biomarkers in cardiovascular medicine. European heart journal\| PubMed ID: 25888005	2015
Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional respon... European heart journal\| PubMed ID: 25982896	2015
Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation. Journal of the American College of Cardiology\| PubMed ID: 26022821	2015
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron\| PubMed ID: 26087165	2015
Flow patterns in externally stented saphenous vein grafts and development of intimal hyperplasia. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 26242834	2015
How does coronary stent implantation impact on the status of the microcirculation during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction? European heart journal\| PubMed ID: 26254178	2015
Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension. Vascular pharmacology\| PubMed ID: 26276526	2016
Zero-Flow Pressure Measured Immediately After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Provides the Best Invasive Index for Predicting the Ex... JACC. Cardiovascular interventions\| PubMed ID: 26404192	2015
Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 26552047	2016
Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo. Scientific reports\| PubMed ID: 26620767	2015
OCT imaging of aorto-coronary vein graft pathology modified by external stenting: 1-year post-surgery. European heart journal. Cardiovascular Imaging\| PubMed ID: 26628615	2016
Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocol. BMJ open\| PubMed ID: 26743702	2016
Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling. Circulation research\| PubMed ID: 26838789	2016
Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling. Journal of the American Heart Association\| PubMed ID: 27001967	2016
A global call for action to include gender in research impact assessment. Health research policy and systems\| PubMed ID: 27432056	2016
Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 27456522	2016
Refining the Enrolment Process in Emergency Medicine Research. The European journal of cardiovascular medicine\| PubMed ID: 27499840	2016
Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo. eLife\| PubMed ID: 27572261	2016
Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia. Molecular therapy. Nucleic acids\| PubMed ID: 27824334	2016
Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27908893	2017
The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST-elevation myocardial infarction. Coronary artery disease\| PubMed ID: 27926579	2017
Splenic T1-mapping: a novel quantitative method for assessing adenosine stress adequacy for cardiovascular magnetic resonance. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 28081721	2017
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance. Free radical biology & medicine\| PubMed ID: 28104455	2017
A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice. British journal of pharmacology\| PubMed ID: 28128438	2017
The Subcellular Localisation of Neuronal Nitric Oxide Synthase Determines the Downstream Effects of NO on Myocardial Function. Cardiovascular research\| PubMed ID: 28158509	2017
A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 28360334	2017
Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress. European heart journal\| PubMed ID: 28444175	2017
Linking noise to cardiovascular disease pathogenesis. European heart journal\| PubMed ID: 28633421	2017
A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption. Clinical proteomics\| PubMed ID: 28642677	2017
Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes. Antioxidants & redox signaling\| PubMed ID: 28661198	2018
Detecting human coronary inflammation by imaging perivascular fat. Science translational medicine\| PubMed ID: 28701474	2017
Maximising value from a United Kingdom Biomedical Research Centre: study protocol. Health research policy and systems\| PubMed ID: 28806989	2017
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction. JCI insight\| PubMed ID: 28878126	2017
Mammalian γ2 AMPK regulates intrinsic heart rate. Nature communications\| PubMed ID: 29097735	2017
Index of Microcirculatory Resistance at the Time of Primary Percutaneous Coronary Intervention Predicts Early Cardiac Complications: Insights From the OxAMI (Oxford Study in Acute Myocardial... Journal of the American Heart Association\| PubMed ID: 29113999	2017
3D reconstruction of coronary arteries from 2D angiographic projections using non-uniform rational basis splines (NURBS) for accurate modelling of coronary stenoses. PloS one\| PubMed ID: 29298341	2018
Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease. Journal of the American College of Cardiology\| PubMed ID: 29495995	2018
Diagnosis of Microvascular Angina Using Cardiac Magnetic Resonance. Journal of the American College of Cardiology\| PubMed ID: 29495996	2018
Effects Of Endothelin-1 On Intracellular Tetrahydrobiopterin Levels In Vascular Tissue. Scandinavian cardiovascular journal : SCJ\| PubMed ID: 29566572	2018
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression. Cardiovascular research\| PubMed ID: 29596571	2018
Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury. Journal of the American Heart Association\| PubMed ID: 29626151	2018
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control. Vascular pharmacology\| PubMed ID: 29654907	2018
Index of Microcirculatory Resistance as a Tool to Characterize Microvascular Obstruction and to Predict Infarct Size Regression in Patients With STEMI Undergoing Primary PCI. JACC. Cardiovascular imaging\| PubMed ID: 29680355	2019
JCAD, a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29794114	2018
Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 29844152	2018
Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice. Atherosclerosis\| PubMed ID: 30048944	2018
Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data... Lancet (London, England)\| PubMed ID: 30170852	2018
Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation. Scientific reports\| PubMed ID: 30254268	2018
Neonatal Micro-RNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 30287978	2018
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature\| PubMed ID: 30405245	2018
Long-term performance of an external stent for saphenous vein grafts: the VEST IV trial. Journal of cardiothoracic surgery\| PubMed ID: 30453984	2018
Dynamic changes in injured myocardium, very early after acute myocardial infarction, quantified using T1 mapping cardiovascular magnetic resonance. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 30567572	2018
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin. Nature communications\| PubMed ID: 30573728	2018
Acute Microvascular Impairment Post-Reperfused STEMI Is Reversible and Has Additional Clinical Predictive Value: A CMR OxAMI Study. JACC. Cardiovascular imaging\| PubMed ID: 30660541	2019
Combined T1-mapping and tissue tracking analysis predicts severity of ischemic injury following acute STEMI-an Oxford Acute Myocardial Infarction (OxAMI) study. The international journal of cardiovascular imaging\| PubMed ID: 30778713	2019
Incremental Value of Coronary Microcirculation Resistive Reserve Ratio in Predicting the Extent of Myocardial Infarction in Patients with STEMI. Insights from the Oxford Acute Myocardial Inf... Cardiovascular revascularization medicine : including molecular interventions\| PubMed ID: 30797759	2019
Neuropeptide-Y causes coronary microvascular constriction and is associated with reduced ejection fraction following ST-elevation myocardial infarction. European heart journal\| PubMed ID: 30859228	2019
A macroeconomic assessment of the impact of medical research expenditure: A case study of NIHR Biomedical Research Centres. PloS one\| PubMed ID: 30970015	2019
Safety of Rotational Atherectomy Using the Radial Access in Patients With Severe Aortic Stenosis. The American journal of cardiology\| PubMed ID: 31174836	2019
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation. Cell reports\| PubMed ID: 31269442	2019
Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature. The Journal of clinical investigation\| PubMed ID: 31329158	2019
Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature\| PubMed ID: 31363232	2019
A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. European heart journal\| PubMed ID: 31504423	2019
Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science translational medicine\| PubMed ID: 31534019	2019
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Cardiovascular research\| PubMed ID: 31584065	2020
Exercise and cardiovascular health: new routes to reap more rewards. Cardiovascular research\| PubMed ID: 31593225	2020
Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres. BMJ (Clinical research ed.)\| PubMed ID: 31748235	2019
The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade. European heart journal\| PubMed ID: 31834357	2020
Hyper-acute cardiovascular magnetic resonance T1 mapping predicts infarct characteristics in patients with ST elevation myocardial infarction. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 31915031	2020
Prognostic significance of troponin level in 3121 patients presenting with atrial fibrillation (The NIHR Health Informatics Collaborative TROP-AF study). Journal of the American Heart Association\| PubMed ID: 32212911	2020
Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology. Nitric oxide : biology and chemistry\| PubMed ID: 32339668	2020
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition. Science translational medicine\| PubMed ID: 32350133	2020
Angiography-derived index of microcirculatory resistance as a novel, pressure-wire-free tool to assess coronary microcirculation in ST elevation myocardial infarction. The international journal of cardiovascular imaging\| PubMed ID: 32409977	2020
Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people. Heart (British Cardiac Society)\| PubMed ID: 32737124	2020
Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data. Lancet (London, England)\| PubMed ID: 32861307	2020
Retraction notice to Gadolinium-Free Cardiac MR Stress T1-Mapping to Distinguish Epicardial From Microvascular Coronary Disease: J Am Coll Cardiol 71 (2018) 957-968. Journal of the American College of Cardiology\| PubMed ID: 33059839	2020
Retraction notice to Diagnosis of Microvascular Angina Using Cardiac Magnetic Resonance: J Am Coll Cardiol 71 (2018) 969-979. Journal of the American College of Cardiology\| PubMed ID: 33059840	2020
Atrial nitroso-redox balance and refractoriness following on-pump cardiac surgery: a randomized trial of atorvastatin. Cardiovascular research\| PubMed ID: 33098411	2022
Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers. Handbook of experimental pharmacology\| PubMed ID: 33140223	2021
Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. Nature\| PubMed ID: 33149301	2020
Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release. Circulation\| PubMed ID: 33185461	2021
Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge. EClinicalMedicine\| PubMed ID: 33490928	2021
BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes. Circulation research\| PubMed ID: 33494625	2021
When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping. Cell & bioscience\| PubMed ID: 33726865	2021
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling. The Journal of clinical investigation\| PubMed ID: 33784254	2021
Coronary Microvascular Dysfunction Assessed by Pressure Wire and CMR After STEMI Predicts Long-Term Outcomes. JACC. Cardiovascular imaging\| PubMed ID: 33865789	2021
A titan of Cardiovascular Research: Professor Peter Sleight (1929-2020). Cardiovascular research\| PubMed ID: 33891679	2021
Angiography-derived index of microcirculatory resistance (IMR) as a novel pressure-wire-free tool to assess coronary microvascular dysfunction in acute coronary syndromes and stable coronary... The international journal of cardiovascular imaging\| PubMed ID: 33950329	2021
CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circulation research\| PubMed ID: 33975450	2021
Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease. Journal of the American College of Cardiology\| PubMed ID: 34016263	2021
External stenting and disease progression in saphenous vein grafts two years after coronary artery bypass grafting: A multicenter randomized trial. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 34024615	2021
Pressure-controlled intermittent coronary sinus occlusion improves the vasodilatory microvascular capacity and reduces myocardial injury in patients with STEMI. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions\| PubMed ID: 34051133	2022
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular research\| PubMed ID: 34132807	2021
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis. Circulation\| PubMed ID: 34255973	2021
Effects of canagliflozin on human myocardial redox signalling: clinical implications. European heart journal\| PubMed ID: 34293101	2021
Pre-procedural ATI score (age-thrombus burden-index of microcirculatory resistance) predicts long-term clinical outcomes in patients with ST elevation myocardial infarction treated with prim... International journal of cardiology\| PubMed ID: 34311009	2021
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity. Gastroenterology\| PubMed ID: 34425095	2021
Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovascular research\| PubMed ID: 34450625	2021
Long-Term Clinical Outcomes in Patients With an Acute ST-Segment-Elevation Myocardial Infarction Stratified by Angiography-Derived Index of Microcirculatory Resistance. Frontiers in cardiovascular medicine\| PubMed ID: 34557531	2021
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 34689592	2021
A Randomized, double-blind, dose ranging clinical trial of intravenous FDY-5301 in acute STEMI patients undergoing primary PCI. International journal of cardiology\| PubMed ID: 34774885	2022
A large National Institute for Health Research (NIHR) Biomedical Research Centre facilitates impactful cross-disciplinary and collaborative translational research publications and research c... Journal of translational medicine\| PubMed ID: 34838033	2021
Bruton's TK regulates myeloid cell recruitment during acute inflammation. British journal of pharmacology\| PubMed ID: 34897650	2022
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nature medicine\| PubMed ID: 34907393	2022
Cardiovascular computed tomography imaging for coronary artery disease risk: plaque, flow and fat. Heart (British Cardiac Society)\| PubMed ID: 35022211	2022
Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles. Cardiovascular research\| PubMed ID: 35134856	2022
Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study. PLoS medicine\| PubMed ID: 35192610	2022
Prognostic Significance of Ventricular Arrhythmias in 13 444 Patients With Acute Coronary Syndrome: A Retrospective Cohort Study Based on Routine Clinical Data (NIHR Health Informatics Colla... Journal of the American Heart Association\| PubMed ID: 35258317	2022
Implications of elevated troponin on time-to-surgery in non-ST elevation myocardial infarction (NIHR Health Informatics Collaborative: TROP-CABG study). International journal of cardiology\| PubMed ID: 35487318	2022