Mark J. Crabtree

BHF Centre of Research Excellence, University of Oxford

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2022

Other Publications

Article	Year
Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with... The Journal of biological chemistry\| PubMed ID: 19011239	2009
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression. The Journal of biological chemistry\| PubMed ID: 19286659	2009
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis... The Journal of biological chemistry\| PubMed ID: 19666465	2009
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. Free radical biology & medicine\| PubMed ID: 21402147	2011
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric oxide : biology and chemistry\| PubMed ID: 21550412	2011
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice. Cardiovascular research\| PubMed ID: 22287576	2012
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. Circulation\| PubMed ID: 22315282	2012
Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling. Current heart failure reports\| PubMed ID: 22711313	2012
Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation. Circulation research\| PubMed ID: 22798524	2012
Nitric oxide synthases in heart failure. Antioxidants & redox signaling\| PubMed ID: 22871241	2013
Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification. European heart journal\| PubMed ID: 23008511	2012
Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. The Journal of biological chemistry\| PubMed ID: 23091050	2012
Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling. The Journal of biological chemistry\| PubMed ID: 23139420	2013
A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization. The Journal of biological chemistry\| PubMed ID: 23965989	2013
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free radical biology & medicine\| PubMed ID: 24148766	2014
Tetrahydrobiopterin in cardiovascular health and disease. Antioxidants & redox signaling\| PubMed ID: 24294830	2014
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 24777984	2014
Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection. Circulation\| PubMed ID: 24807872	2014
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain : a journal of neurology\| PubMed ID: 25398233	2015
Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation. Free radical biology & medicine\| PubMed ID: 25451639	2015
A requirement for Gch1 and tetrahydrobiopterin in embryonic development. Developmental biology\| PubMed ID: 25557619	2015
CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 25916729	2015
Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide. The Journal of physiology\| PubMed ID: 26752781	2016
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance. Free radical biology & medicine\| PubMed ID: 28104455	2017
A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice. British journal of pharmacology\| PubMed ID: 28128438	2017
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression. Cardiovascular research\| PubMed ID: 29596571	2018
Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation. Scientific reports\| PubMed ID: 30254268	2018
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin. Nature communications\| PubMed ID: 30573728	2018
Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation. Cell reports\| PubMed ID: 31269442	2019
Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology. Nitric oxide : biology and chemistry\| PubMed ID: 32339668	2020
Atrial nitroso-redox balance and refractoriness following on-pump cardiac surgery: a randomized trial of atorvastatin. Cardiovascular research\| PubMed ID: 33098411	2022
Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis. Circulation\| PubMed ID: 34255973	2021
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity. Gastroenterology\| PubMed ID: 34425095	2021
Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine. Biochemical Society transactions\| PubMed ID: 34665229	2021
Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 34689592	2021