investigating-migraine-like-behavior-using-light-aversion-in-mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Migraine is a complex neurological disorder characterized by headache and sensory abnormalities, such as hypersensitivity to light, observed as ...

University of Iowa

With the approval of calcitonin gene-related peptide (CGRP) and CGRP receptor monoclonal antibodies by the Federal Drug Administration, a new era in the treatment of migraine patients is beginning. However, there are still many unknowns in terms of CGRP mechanisms of action that need to be elucidated to allow new advances in migraine therapies. CGRP has been studied both clinically and preclinically since its discovery. Here we review some of the preclinical data regarding CGRP in animal models of migraine.

CGRP in Animal Models of Migraine.

A hallmark of migraine is photophobia. In mice, photophobia-like behavior is induced by calcitonin gene-related peptide (CGRP), a neuropeptide known to be a key player in migraine. In this study, we sought to identify sites within the brain from which CGRP could induce photophobia.

Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice.

Circadian patterns of migraine attacks have been reported by patients but remain understudied. In animal models, circadian phases are generally not taken into consideration. In particular, rodents are nocturnal animals, yet they are most often tested during their inactive phase during the day. This study aims to test the validity of CGRP-induced behavioral changes in mice by comparing responses during the active and inactive phases.

Article	Year
CGRP in Animal Models of Migraine. Handbook of experimental pharmacology\| PubMed ID: 30689086	2019
Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice. Headache\| PubMed ID: 32750230	2020
CGRP induces migraine-like symptoms in mice during both the active and inactive phases. The journal of headache and pain\| PubMed ID: 34193048	2021

Mengya Wang

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