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Investigating Migraine-Like Behavior Using Light Aversion in Mice

Article DOI: 10.3791/62839-v • 05:23 min • August 11th, 2021
August 11th, 2021 •
1, 2, 3,4, 4, 3,4, 3,4,5
1Department of Neuroscience and Pharmacology, University of Iowa, 2School of Behavioral and Brain Sciences, University of Texas at Dallas, 3Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, 4Department of Molecular Physiology and Biophysics, University of Iowa, 5Department of Neurology, University of Iowa

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Summary
Automatic Translation

Rodents are not able to report migraine symptoms. Here, we describe a manageable test paradigm (light/dark and open field assays) to measure light aversion, one of the most common and bothersome symptoms in patients with migraines.

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Migraine-like Behavior Light Aversion Photophobia Preclinical Behavioral Surrogate Automatic Detection Convenience Anxiety Light/dark Assay Apparatus Light Intensity Dark Insert Tracking Software Protocol Setting Analysis Setting Zone Setting Habituation Circadian Rhythm Equipment Acclimate Acquire Data Mouse IDs Start The Protocol
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