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Investigating Migraine-Like Behavior Using Light Aversion in Mice
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JoVE Journal Behavior
Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

DOI:
10.3791/62839-v

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05:23 min

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August 11, 2021

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, , , , ,
1Department of Neuroscience and Pharmacology,University of Iowa, 2School of Behavioral and Brain Sciences,University of Texas at Dallas, 3Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, 4Department of Molecular Physiology and Biophysics,University of Iowa, 5Department of Neurology,University of Iowa

Chapters

  • 00:04Introduction
  • 00:42Light/Dark Assay
  • 02:54Open Field Assay
  • 03:54Results: Migraine-Like Behavior Using Light Aversion in Mice
  • 04:54Conclusion

Summary

Automatic Translation

Automatic Translation

Rodents are not able to report migraine symptoms. Here, we describe a manageable test paradigm (light/dark and open field assays) to measure light aversion, one of the most common and bothersome symptoms in patients with migraines.

Tags

Keywords: MigraineLight AversionPhotophobiaLight/dark AssayBehavioral AssayMouse ModelCGRPAnxietyAutomatic DetectionPreclinicalSurrogateAcclimation

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