Fiona Oakley

Newcastle Fibrosis Research Group, Newcastle University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2021

Other Publications

Article	Year
NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. Journal of hepatology\| PubMed ID: 18279996	2008
Nuclear factor-kappaB1: regulation and function. The international journal of biochemistry & cell biology\| PubMed ID: 17693123	2008
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology\| PubMed ID: 19303015	2009
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology\| PubMed ID: 19843474	2010
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology (Baltimore, Md.)\| PubMed ID: 20058312	2010
The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes. Journal of hepatology\| PubMed ID: 20579762	2010
BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis. Oncogene\| PubMed ID: 21963853	2012
Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease. Nature medicine\| PubMed ID: 22120177	2011
The NF-ÎºB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. The American journal of pathology\| PubMed ID: 22210479	2012
Roles of c-Rel signalling in inflammation and disease. The international journal of biochemistry & cell biology\| PubMed ID: 22405852	2012
Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology (Baltimore, Md.)\| PubMed ID: 22488473	2012
Mechanisms and biomarkers of apoptosis in liver disease and fibrosis. International journal of hepatology\| PubMed ID: 22567408	2012
Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nature medicine\| PubMed ID: 22941276	2012
Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. Hepatology (Baltimore, Md.)\| PubMed ID: 22996371	2013
Serotonin paracrine signaling in tissue fibrosis. Biochimica et biophysica acta\| PubMed ID: 23032152	2013
Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells ... Hepatology (Baltimore, Md.)\| PubMed ID: 23080298	2013
The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice. The American journal of pathology\| PubMed ID: 23562440	2013
Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 24235770	2014
Noninvasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker. Hepatology (Baltimore, Md.)\| PubMed ID: 24242936	2014
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. Journal of hepatology\| PubMed ID: 24333183	2014
Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. PloS one\| PubMed ID: 24416163	2014
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature communications\| PubMed ID: 24960204	2014
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease. Journal of hepatology\| PubMed ID: 26264933	2015
Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation. PloS one\| PubMed ID: 26302150	2015
Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 26814616	2016
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease. Scientific reports\| PubMed ID: 26831567	2016
Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum. Annual review of pathology\| PubMed ID: 26980160	2016
TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27053764	2016
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo. Journal of hepatology\| PubMed ID: 27067455	2016
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28129116	2017
The NF-κB1 is a key regulator of acute but not chronic renal injury. Cell death & disease\| PubMed ID: 28617440	2017
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage. Gut\| PubMed ID: 29374630	2018
The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. Hepatology communications\| PubMed ID: 29404476	2017
Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway. Nucleic acids research\| PubMed ID: 29873780	2018
Rapamycin improves healthspan but not inflammaging in nfκb1 mice. Aging cell\| PubMed ID: 30468013	2019
Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30608881	2019
Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near-Infrared BODIPY Dye. ChemMedChem\| PubMed ID: 30920173	2019
A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices. Hepatology (Baltimore, Md.)\| PubMed ID: 30963615	2019
Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: association with hepatic stellate cell activation and patient outcome. Virchows Archiv : an international journal of pathology\| PubMed ID: 31201503	2019
Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells. Gastroenterology\| PubMed ID: 31352003	2019
Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease. Hepatology (Baltimore, Md.)\| PubMed ID: 31378982	2020
Editorial overview: Fibrosis. Current opinion in pharmacology\| PubMed ID: 31699602	2019
Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy. Current opinion in pharmacology\| PubMed ID: 31731225	2019
Loss of ELK1 has differential effects on age-dependent organ fibrosis. The international journal of biochemistry & cell biology\| PubMed ID: 31877385	2020
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis. JCI insight\| PubMed ID: 32102985	2020
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis. Gut\| PubMed ID: 32327527	2021
Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma. Hepatology (Baltimore, Md.)\| PubMed ID: 32460431	2021
Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis. The Journal of clinical investigation\| PubMed ID: 32603313	2020
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse. Ecotoxicology and environmental safety\| PubMed ID: 32634706	2020
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis. Nature metabolism\| PubMed ID: 32694734	2020
cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis. Rheumatology (Oxford, England)\| PubMed ID: 32725139	2020
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. Gut\| PubMed ID: 32907830	2021
Anti-inflammatory treatment rescues memory deficits during aging in nfkb1 mice. Aging cell\| PubMed ID: 32915495	2020
Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis. Nature cancer\| PubMed ID: 33073241	2020
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis. Nature metabolism\| PubMed ID: 33168981	2020
RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat. Scientific reports\| PubMed ID: 33303921	2020
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis. Nature metabolism\| PubMed ID: 33303984	2021
Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging. Scientific reports\| PubMed ID: 33446811	2021
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Molecular metabolism\| PubMed ID: 33722690	2021
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. The EMBO journal\| PubMed ID: 33764576	2021
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis. Hepatology (Baltimore, Md.)\| PubMed ID: 34233024	2021
Key features of the environment promoting liver cancer in the absence of cirrhosis. Scientific reports\| PubMed ID: 34408183	2021