Edward Perez-Reyes

Department of Pharmacology, University of Virginia

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2021

Other Publications

Article	Year
Low-voltage-activated Ca2+ currents are generated by members of the CavT subunit family (alpha1G/H) in rat primary sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9786968	1998
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10066243	1999
Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2). The Journal of biological chemistry\| PubMed ID: 10766861	2000
Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11487633	2001
Gating kinetics of the alpha1I T-type calcium channel. The Journal of general physiology\| PubMed ID: 11696605	2001
Stimulation of recombinant Ca(v)3.2, T-type, Ca(2+) channel currents by CaMKIIgamma(C). The Journal of physiology\| PubMed ID: 11790804	2002
Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation. Biophysical journal\| PubMed ID: 12080115	2002
Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1). FEBS letters\| PubMed ID: 12297319	2002
Molecular physiology of low-voltage-activated t-type calcium channels. Physiological reviews\| PubMed ID: 12506128	2003
Cloning of a novel one-repeat calcium channel-like gene. Biochemical and biophysical research communications\| PubMed ID: 12646162	2003
Paradoxical role of T-type calcium channels in coronary smooth muscle. Molecular interventions\| PubMed ID: 14993472	2004
Functional impact of alternative splicing of human T-type Cav3.3 calcium channels. Journal of neurophysiology\| PubMed ID: 15254077	2004
The role of voltage gated T-type Ca2+ channel isoforms in mediating "capacitative" Ca2+ entry in cancer cells. Cell calcium\| PubMed ID: 15488598	2004
Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. British journal of pharmacology\| PubMed ID: 15644869	2005
Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15888660	2005
Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels. FEBS letters\| PubMed ID: 15987636	2005
The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16177046	2005
CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. The Journal of physiology\| PubMed ID: 16644797	2006
Molecular characterization of T-type calcium channels. Cell calcium\| PubMed ID: 16759699	2006
Molecular biology of T-type calcium channels. CNS & neurological disorders drug targets\| PubMed ID: 17168745	2006
The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17215393	2007
Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17670971	2007
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18003836	2007
Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels. The Journal of biological chemistry\| PubMed ID: 18218623	2008
I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PloS one\| PubMed ID: 18714336	2008
Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels. FEBS letters\| PubMed ID: 18930057	2008
Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity. PloS one\| PubMed ID: 18958281	2008
Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18974361	2009
Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19641113	2009
Orientation of palmitoylated CaVbeta2a relative to CaV2.2 is critical for slow pathway modulation of N-type Ca2+ current by tachykinin receptor activation. The Journal of general physiology\| PubMed ID: 19858358	2009
Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channels. The Journal of biological chemistry\| PubMed ID: 19940152	2010
Role of voltage-gated calcium channels in epilepsy. Pflugers Archiv : European journal of physiology\| PubMed ID: 20091047	2010
T-type Ca(2+) channel modulation by otilonium bromide. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20203058	2010
Characterization of the gating brake in the I-II loop of CaV3 T-type calcium channels. Channels (Austin, Tex.)\| PubMed ID: 21099341	2010
The voltage dependence of gating currents of the neuronal CA(v)3.3 channel is determined by the gating brake in the I-II loop. Pflugers Archiv : European journal of physiology\| PubMed ID: 21340458	2011
Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A(1)-receptor activation. Epilepsia\| PubMed ID: 22126400	2012
Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. The Journal of general physiology\| PubMed ID: 22371363	2012
Effects of eugenol on T-type Ca2+ channel isoforms. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 24014106	2013
Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility. The Journal of physiology\| PubMed ID: 24277868	2014
A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia\| PubMed ID: 24299204	2014
Ins and outs of T-channel structure function. Pflugers Archiv : European journal of physiology\| PubMed ID: 24337909	2014
PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Science (New York, N.Y.)\| PubMed ID: 26068853	2015
CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. Genes & development\| PubMed ID: 26220996	2015
Contrasting the roles of the I-II loop gating brake in CaV3.1 and CaV3.3 calcium channels. Pflugers Archiv : European journal of physiology\| PubMed ID: 26306541	2015
Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake. Frontiers in behavioral neuroscience\| PubMed ID: 27065827	2016
Central Mechanisms Mediating Thrombospondin-4-induced Pain States. The Journal of biological chemistry\| PubMed ID: 27129212	2016
Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27488637	2016
Ca Regulation of Ca3.3 T-type Ca Channel Is Mediated by Calmodulin. Molecular pharmacology\| PubMed ID: 28696213	2017
Calmodulin regulates Ca3 T-type channels at their gating brake. The Journal of biological chemistry\| PubMed ID: 28972185	2017
A novel therapeutic approach for treatment of catamenial epilepsy. Neurobiology of disease\| PubMed ID: 29274741	2018
Functional variants in and may contribute to genetic generalized epilepsy. Epilepsia open\| PubMed ID: 29588962	2017
CACHD1 is an α2δ-Like Protein That Modulates Ca3 Voltage-Gated Calcium Channel Activity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 30181139	2018
LMO7 deficiency reveals the significance of the cuticular plate for hearing function. Nature communications\| PubMed ID: 30850599	2019
Primary aldosteronism associated with a germline variant in . BMJ case reports\| PubMed ID: 31126930	2019
Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy. Epilepsy research\| PubMed ID: 31132598	2019
Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy. Epilepsia\| PubMed ID: 32954490	2020
A brainstem peptide system activated at birth protects postnatal breathing. Nature\| PubMed ID: 33268898	2021
Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology\| PubMed ID: 33721255	2021