Hiroshi Handa

Department of Chemical Biology, Tokyo Medical University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nature communications\| PubMed ID: 24968874	2014
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nature structural & molecular biology\| PubMed ID: 25108355	2014
Myeloid disease: Another action of a thalidomide derivative. Nature\| PubMed ID: 26131932	2015
Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex. Molecular and cellular biology\| PubMed ID: 26217014	2015
CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription. Transcription\| PubMed ID: 26399478	2015
Correction for Cao et al., Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex. Molecular and cellular biology\| PubMed ID: 26518638	2015
Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. International journal of oncology\| PubMed ID: 26718641	2016
Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS chemical biology\| PubMed ID: 26863403	2016
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nature communications\| PubMed ID: 26988023	2016
Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Molecular cell\| PubMed ID: 26990986	2016
Discovery of the target for immunomodulatory drugs (IMiDs). [Rinsho ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 27263779	2016
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature\| PubMed ID: 27338790	2016
Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. International journal of hematology\| PubMed ID: 27460676	2016
Cystathionine β-synthase and PGRMC1 as CO sensors. Free radical biology & medicine\| PubMed ID: 27565814	2016
SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads regardless of their sizes and shapes. Biotechnology reports (Amsterdam, Netherlands)\| PubMed ID: 28435806	2015
The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK. Marine drugs\| PubMed ID: 28783126	2017
Recent topics in IMiDs and cereblon. [Rinsho ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 28978850	2017
Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis. International journal of hematology\| PubMed ID: 28986762	2018
Effect of ruxolitinib therapy on the quality-of-life of Japanese patients with myelofibrosis. Current medical research and opinion\| PubMed ID: 29224367	2018
Structural basis of thalidomide enantiomer binding to cereblon. Scientific reports\| PubMed ID: 29358579	2018
Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma. Blood\| PubMed ID: 29685921	2018
NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation. The Journal of experimental medicine\| PubMed ID: 29934320	2018
Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera. Clinical chemistry\| PubMed ID: 30021922	2018
Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1. Journal of clinical biochemistry and nutrition\| PubMed ID: 30087538	2018
Application of high-performance magnetic nanobeads to biological sensing devices. Analytical and bioanalytical chemistry\| PubMed ID: 30627798	2019
Magnetically Promoted Rapid Immunofluorescence Staining for Frozen Tissue Sections. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 30958084	2019
Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience\| PubMed ID: 31055217	2019
Arginine induces IGF-1 secretion from the endoplasmic reticulum. Biochemical and biophysical research communications\| PubMed ID: 31101333	2019
Molecular mechanisms of cereblon-based drugs. Pharmacology & therapeutics\| PubMed ID: 31202702	2019
Estradiol accelerates liver regeneration through estrogen receptor α. Clinical and experimental gastroenterology\| PubMed ID: 31413616	2019
Successful Management of Acquired Factor V Inhibitor by Monitoring Factor V Activity, Antigen, and Inhibitor Values during Immunosuppressive Therapy. Acta haematologica\| PubMed ID: 31563916	2020
p63 is a cereblon substrate involved in thalidomide teratogenicity. Nature chemical biology\| PubMed ID: 31591562	2019
[Cereblon as a primary target of IMiDs]. [Rinsho ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 31597822	2019
Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nature communications\| PubMed ID: 32081878	2020
Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide. Scientific reports\| PubMed ID: 32132601	2020
Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites. NPJ science of food\| PubMed ID: 32133417	2020
Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug-induced thrombocytopenia. Blood\| PubMed ID: 32219443	2020
Molecular Mechanisms of the Teratogenic Effects of Thalidomide. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 32414180	2020
UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner. Biochemical and biophysical research communications\| PubMed ID: 32423812	2020
Induction of adaptive immune responses against antigens incorporated within the capsid of simian virus 40. The Journal of general virology\| PubMed ID: 32501197	2020
Molecular mechanisms of thalidomide and its derivatives. Proceedings of the Japan Academy. Series B, Physical and biological sciences\| PubMed ID: 32522938	2020
Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32848052	2020
-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer. Cancers\| PubMed ID: 32878320	2020
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells. Communications biology\| PubMed ID: 32901087	2020
ARID2 is a pomalidomide-dependent CRL4 substrate in multiple myeloma cells. Nature chemical biology\| PubMed ID: 32958952	2020
Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. PLoS biology\| PubMed ID: 32991574	2020
Do not curse the darkness of the spinal cord, light TDP-43. Neural regeneration research\| PubMed ID: 33229745	2021
Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells. Cellular signalling\| PubMed ID: 33592249	2021
Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS. Cellular and molecular life sciences : CMLS\| PubMed ID: 33709256	2021
Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma. Journal of experimental & clinical cancer research : CR\| PubMed ID: 33757580	2021
Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Frontiers in cell and developmental biology\| PubMed ID: 33777938	2021
Illuminating ALS Motor Neurons With Optogenetics in Zebrafish. Frontiers in cell and developmental biology\| PubMed ID: 33816488	2021
Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells. Molecular cancer therapeutics\| PubMed ID: 33879556	2021
BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Scientific reports\| PubMed ID: 33888730	2021
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology. Cell chemical biology\| PubMed ID: 34033753	2021
Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1. Cancers\| PubMed ID: 34209885	2021
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates. Communications biology\| PubMed ID: 34764413	2021
Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology. Cancers\| PubMed ID: 35053527	2022