kinetx-combined-flow-cytometry-assay-analysis-software-framework-to

Kinetx: A Combined Flow Cytometry Assay and Analysis Software Framework to Quantitatively Measure and Categorize Platelet Activation in Real-time.

Platelets react rapidly to vascular injury and undergo activation in response to a range of stimuli to limit blood loss. Many platelet function tests ...

University of Reading

EDI(torial): equality, diversity, and inclusion and  - 2021.

Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction. Pannexins are structurally related to the connexins but extensive glycosylation of these channels prevents docking to form gap junctions and they function as membrane channels. Platelets express pannexin-1 and several connexin family members (Cx37, Cx40 and Cx62). These channels are permeable to molecules up to 1,000 Daltons in molecular mass and functional studies demonstrate their role in non-vesicular ATP release. Channel activation is regulated by (patho)physiological stimuli, such as mechanical stimulation, making them attractive potential drug targets for the management of arterial thrombosis. This review explores the structure and function of platelet pannexin-1 and connexins, the mechanisms by which they are gated and their therapeutic potential.

Article	Year
EDI(torial): equality, diversity, and inclusion and - 2021. Platelets\| PubMed ID: 33284674	2021
Mind the gap: connexins and pannexins in platelet function. Platelets\| PubMed ID: 33818243	2021
Ion channels and ion homeostasis in the platelet and megakaryocyte. Platelets\| PubMed ID: 34370618	2021

Kirk A. Taylor

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