Jonathan M. Gibbins

ICMR, University of Reading

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2021

Other Publications

Article	Year
Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets. Blood\| PubMed ID: 34315173	2021
Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. Blood\| PubMed ID: 11756163	2002
Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. The Journal of biological chemistry\| PubMed ID: 11825911	2002
The negative regulation of platelet function: extending the role of the ITIM. Trends in cardiovascular medicine\| PubMed ID: 12161075	2002
The role of polyphenolic compounds in the diet as inhibitors of platelet function. The Proceedings of the Nutrition Society\| PubMed ID: 14506895	2003
Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function? FEBS letters\| PubMed ID: 14550568	2003
Tachykinins regulate the function of platelets. Blood\| PubMed ID: 15130944	2004
Platelet adhesion signalling and the regulation of thrombus formation. Journal of cell science\| PubMed ID: 15252124	2004
Techniques for analysis of proteins by SDS-polyacrylamide gel electrophoresis and Western blotting. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15308799	2004
Study of tyrosine kinases and protein tyrosine phosphorylation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15308800	2004
A role for the thiol isomerase protein ERP5 in platelet function. Blood\| PubMed ID: 15466936	2005
Platelet PECAM-1 inhibits thrombus formation in vivo. Blood\| PubMed ID: 16166583	2006
Extracellular disulfide exchange and the regulation of cellular function. Antioxidants & redox signaling\| PubMed ID: 16677077	2006
Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. The British journal of nutrition\| PubMed ID: 16925853	2006
Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets. Blood\| PubMed ID: 17213293	2007
In vivo selection for metastasis promoting genes in the mouse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17420453	2007
Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood\| PubMed ID: 17895403	2008
The neurokinin 1 receptor: a potential new target for anti-platelet therapy? Current opinion in pharmacology\| PubMed ID: 18296119	2008
A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood\| PubMed ID: 18772455	2008
Tweaking the gain on platelet regulation: the tachykinin connection. Atherosclerosis\| PubMed ID: 19150714	2009
A functional proteomic method for the enrichment of peripheral membrane proteins reveals the collagen binding protein Hsp47 is exposed on the surface of activated human platelets. Journal of proteome research\| PubMed ID: 19341245	2009
Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics\| PubMed ID: 19725075	2009
PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways. FEBS letters\| PubMed ID: 19850043	2009
Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. British journal of haematology\| PubMed ID: 19995400	2010
A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. British journal of pharmacology\| PubMed ID: 20148891	2010
Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. PloS one\| PubMed ID: 20300193	2010
Platelet-mediated metabolism of the common dietary flavonoid, quercetin. PloS one\| PubMed ID: 20300638	2010
Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. PLoS neglected tropical diseases\| PubMed ID: 20706583	2010
LXR as a novel antithrombotic target. Blood\| PubMed ID: 21411760	2011
Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros. PloS one\| PubMed ID: 21731776	2011
Regulation of platelet biology by platelet endothelial cell adhesion molecule-1. Platelets\| PubMed ID: 22035359	2012
Analysis of protein networks in resting and collagen receptor (GPVI)-stimulated platelet sub-proteomes. Proteomics\| PubMed ID: 22114104	2011
Clot retraction. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130703	2012
Endogenous inhibitory mechanisms and the regulation of platelet function. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22130718	2012
JAMming the signals. Blood\| PubMed ID: 22493215	2012
Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation\| PubMed ID: 22528526	2012
Rhinocetin, a venom-derived integrin-specific antagonist inhibits collagen-induced platelet and endothelial cell functions. The Journal of biological chemistry\| PubMed ID: 22689571	2012
Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs. Cardiovascular research\| PubMed ID: 23024269	2013
Sequence and phylogenetic analysis of viper venom serine proteases. Bioinformation\| PubMed ID: 23055627	2012
The integration of proteomics and systems approaches to map regulatory mechanisms underpinning platelet function. Proteomics. Clinical applications\| PubMed ID: 23184887	2013
Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice. Blood\| PubMed ID: 23788140	2013
Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor. The Journal of infectious diseases\| PubMed ID: 23911710	2013
Antithrombotic actions of statins involve PECAM-1 signaling. Blood\| PubMed ID: 24030383	2013
Connexin40 regulates platelet function. Nature communications\| PubMed ID: 24096827	2013
Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments. Food & function\| PubMed ID: 24121953	2013
Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24135020	2013
Platelets using proteins creatively. Blood\| PubMed ID: 24263955	2013
Snakebite and its socio-economic impact on the rural population of Tamil Nadu, India. PloS one\| PubMed ID: 24278244	2013
Ibuprofen inhibits migration and proliferation of human coronary artery smooth muscle cells by inducing a differentiated phenotype: role of peroxisome proliferator-activated receptor γ. The Journal of pharmacy and pharmacology\| PubMed ID: 24438071	2014
Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase ... Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24969778	2014
Discovery of novel GPVI receptor antagonists by structure-based repurposing. PloS one\| PubMed ID: 24971515	2014
EphB2 regulates contact-dependent and contact-independent signaling to control platelet function. Blood\| PubMed ID: 25370417	2015
Pharmacological actions of nobiletin in the modulation of platelet function. British journal of pharmacology\| PubMed ID: 25988959	2015
Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis. Biochemical Society transactions\| PubMed ID: 26009196	2015
GRID and docking analyses reveal a molecular basis for flavonoid inhibition of Src family kinase activity. The Journal of nutritional biochemistry\| PubMed ID: 26140983	2015
Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26359510	2015
Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function. PloS one\| PubMed ID: 26551971	2015
Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach. PLoS computational biology\| PubMed ID: 26584182	2015
Platelets stop us leaking. Blood\| PubMed ID: 27013214	2016
Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27079884	2016
Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27758768	2016
Challenges in diagnosing and treating snakebites in a rural population of Tamil Nadu, India: The views of clinicians. Toxicon : official journal of the International Society on Toxinology\| PubMed ID: 28238804	2017
RXR Ligands Negatively Regulate Thrombosis and Hemostasis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28254816	2017
Evidence for shear-mediated Ca entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. The Journal of biological chemistry\| PubMed ID: 28416610	2017
Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28619996	2017
Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. PloS one\| PubMed ID: 29136006	2017
Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood advances\| PubMed ID: 29296914	2017
Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones. Physics of life reviews\| PubMed ID: 29550179	2018
NADPH oxidase 2 (NOX2): A key target of oxidative stress-mediated platelet activation and thrombosis. Trends in cardiovascular medicine\| PubMed ID: 29661712	2018
Connexins and Pannexins in Vascular Function and Disease. International journal of molecular sciences\| PubMed ID: 29874791	2018
Talin is a substrate for SUMOylation in migrating cancer cells. Experimental cell research\| PubMed ID: 30003879	2018
Functional redundancy between RAP1 isoforms in murine platelet production and function. Blood\| PubMed ID: 30131434	2018
Screening and High-Throughput Platelet Assays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30171573	2018
Mathematical Techniques for Understanding Platelet Regulation and the Development of New Pharmacological Approaches. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30171583	2018
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets\| PubMed ID: 30252580	2019
The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation. Blood advances\| PubMed ID: 30413433	2018
Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors. Haematologica\| PubMed ID: 30630981	2019
Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion. Pediatric research\| PubMed ID: 30742030	2019
The formyl peptide fMLF primes platelet activation and augments thrombus formation. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 31033193	2019
The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects. TH open : companion journal to thrombosis and haemostasis\| PubMed ID: 31367693	2019
Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 31680418	2020
Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific reports\| PubMed ID: 31748641	2019
Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria. Blood advances\| PubMed ID: 31891656	2020
Ca waves coordinate purinergic receptor-evoked integrin activation and polarization. Science signaling\| PubMed ID: 31964805	2020
Myricetin, the Main Flavonoid in Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5. Frontiers in pharmacology\| PubMed ID: 32116678	2019
Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling. Biophysical journal\| PubMed ID: 32396849	2020
Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling. Haematologica\| PubMed ID: 32467143	2021
A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data. Scientific reports\| PubMed ID: 32764630	2020
Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood\| PubMed ID: 32822477	2021
Zafirlukast is a broad-spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times. British journal of pharmacology\| PubMed ID: 33080041	2021
Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific reports\| PubMed ID: 33446734	2021
Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function. Free radical biology & medicine\| PubMed ID: 33548451	2021
Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B. Platelets\| PubMed ID: 33646086	2021
Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors. Antioxidants (Basel, Switzerland)\| PubMed ID: 33806982	2021
Mind the gap: connexins and pannexins in platelet function. Platelets\| PubMed ID: 33818243	2021
Thiol Isomerases Orchestrate Thrombosis and Hemostasis. Antioxidants & redox signaling\| PubMed ID: 33940944	2021
The protein disulphide isomerase inhibitor CxxCpep modulates oxidative burst and mitochondrial function in platelets. Free radical biology & medicine\| PubMed ID: 34252541	2021
The voltage-gated K channel Kv1.3 modulates platelet motility and αβ integrin-dependent adhesion to collagen. Platelets\| PubMed ID: 34348571	2021
Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors. Biomolecules\| PubMed ID: 34356607	2021
Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood advances\| PubMed ID: 34474473	2021
G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1. Blood advances\| PubMed ID: 34581777	2021