tail-vein-transection-bleeding-model-fully-anesthetized-hemophilia

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Tail bleeding models are important tools in hemophilia research, specifically for the assessment of procoagulant effects. The tail vein transection (TVT) ...

University of Copenhagen

Copenhagen Airport Cohort 1990-2012 presents a unique data source for studies of health effects of occupational exposure to air pollution (ultrafine particles) and manual baggage handling among airport employees. We describe the extent of information in the cohort and in the follow-up based on data linkage to the comprehensive Danish nationwide health registers. In the cohort, all information is linked to the personal identification number that also is used in Denmark Statistics demographic and socioeconomic databases and in the nationwide health registers.

Copenhagen Airport Cohort: air pollution, manual baggage handling and health.

Cardiac arrhythmias and sudden deaths have diurnal rhythms in humans. The underlying mechanisms are unknown. Mice with cardiomyocyte-specific disruption of the molecular clock genes have lower heart rate than control. Because changes in the QT interval on the electrocardiogram is a clinically used marker of risk of arrhythmias, we sought to test if the biological rhythms of QT intervals are dependent on heart rate and if this dependency is changed when the molecular clock is disrupted.

Article	Year
Copenhagen Airport Cohort: air pollution, manual baggage handling and health. BMJ open\| PubMed ID: 28478397	2017
Prolonged QT intervals in mice with cardiomyocyte-specific deficiency of the molecular clock. Acta physiologica (Oxford, England)\| PubMed ID: 34176211	2021

Karin Larsen

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JoVE Journal Publications

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