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1Global Drug Discovery,Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik
Chapters
- 00:05Introduction
- 01:10Beginning of the Experiment
- 02:00Performing Tail Vein Transection
- 02:46Observation Time and Challenges
- 03:49Treatment of Samples
- 04:33Results: Effect of rFVIII After Intravenous Administration
- 07:29Conclusion
The refined tail vein transection (TVT) bleeding model in anesthetized mice is a sensitive in vivo method for the assessment of hemophilic bleeding. This optimized TVT bleeding model uses blood loss and bleeding time as endpoints, refining other models and avoiding death as an endpoint.
