Kullervo Hynynen

Imaging Research, Sunnybrook Research Institute

Affiliated withSunnybrook Research Institute University of Toronto Sunnybrook Health Sciences Centre

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 18	2012
$MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor$ Publication title Cited by 15	2017
Publication title Cited by 7	2022

Other Publications

Article	Year
Focal beam distortion and treatment planning in abdominal focused ultrasound surgery. Medical physics\| PubMed ID: 15984679	2005
Effects of parameter errors in the simulation of transcranial focused ultrasound. Physics in medicine and biology\| PubMed ID: 11814226	2002
The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain. Medical physics\| PubMed ID: 11929019	2002
The temperature dependence of ultrasound-stimulated acoustic emission. Ultrasound in medicine & biology\| PubMed ID: 11978413	2002
Micro-receiver guided transcranial beam steering. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 11989700	2002
Magnetic resonance image-guided focused ultrasound surgery. Cancer journal (Sudbury, Mass.)\| PubMed ID: 12075696	2002
Correlation of ultrasound phase with physical skull properties. Ultrasound in medicine & biology\| PubMed ID: 12079698	2002
Association of rectal toxicity with thermal dose parameters in treatment of locally advanced prostate cancer with radiation and hyperthermia. International journal of radiation oncology, biology, physics\| PubMed ID: 12095557	2002
Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametric study. Physics in medicine and biology\| PubMed ID: 12108775	2002
A unified model for the speed of sound in cranial bone based on genetic algorithm optimization. Physics in medicine and biology\| PubMed ID: 12476974	2002
Interlaboratory acoustic power measurement. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine\| PubMed ID: 12562125	2003
MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology\| PubMed ID: 12616023	2003
Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors. Neuroimaging clinics of North America\| PubMed ID: 12687918	2002
The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). Ultrasound in medicine & biology\| PubMed ID: 12706199	2003
MRI-guided focused ultrasound surgery in the brain: tests in a primate model. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 12768598	2003
The use of ultrasound-stimulated acoustic emission in the monitoring of modulus changes with temperature. Ultrasonics\| PubMed ID: 12788215	2003
Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro. Ultrasound in medicine & biology\| PubMed ID: 14553814	2003
Localized harmonic motion imaging: theory, simulations and experiments. Ultrasound in medicine & biology\| PubMed ID: 14597337	2003
Modeling of anomalies due to hydrophones in continuous-wave ultrasound fields. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 14682632	2003
Forward planar projection through layered media. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 14761040	2003
Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney. Radiology\| PubMed ID: 14764890	2004
Optical monitoring of ultrasound-induced bioeffects in glass catfish. Ultrasound in medicine & biology\| PubMed ID: 14962610	2004
MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 15122673	2004
MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 15122691	2004
Simulation study for thermal dose optimization in ultrasound surgery of the breast. Medical physics\| PubMed ID: 15191322	2004
Apoptosis signals in lymphoblasts induced by focused ultrasound. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15231731	2004
500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 15236372	2004
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound in medicine & biology\| PubMed ID: 15313330	2004
Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery. IEEE transactions on bio-medical engineering\| PubMed ID: 15490817	2004
Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound. Gastroenterology\| PubMed ID: 15508090	2004
Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. NeuroImage\| PubMed ID: 15588592	2005
A numerical study of transcranial focused ultrasound beam propagation at low frequency. Physics in medicine and biology\| PubMed ID: 15815098	2005
A full-wave Helmholtz model for continuous-wave ultrasound transmission. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 15857048	2005
Intracellular delivery of Bak BH3 peptide by microbubble-enhanced ultrasound. Pharmaceutical research\| PubMed ID: 15906165	2005
A new ultrasound method for determining the acoustic phase shifts caused by the skull bone. Ultrasound in medicine & biology\| PubMed ID: 15936493	2005
MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate. Ultrasound in medicine & biology\| PubMed ID: 15972202	2005
Scanning path optimization for ultrasound surgery. Physics in medicine and biology\| PubMed ID: 16030378	2005
A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine\| PubMed ID: 16040827	2005
A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound. Biochemical and biophysical research communications\| PubMed ID: 16081042	2005
MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery. Magnetic resonance imaging clinics of North America\| PubMed ID: 16084419	2005
Feasibility of internally referenced brain temperature imaging with a metabolite signal. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine\| PubMed ID: 16210815	2003
Acoustic transmission losses and field alterations due to human scalp hair. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 16245611	2005
Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16278168	2005
Transcranial ultrasound focus reconstruction with phase and amplitude correction. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 16285450	2005
MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits. Ultrasound in medicine & biology\| PubMed ID: 16286030	2005
Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochemical and biophysical research communications\| PubMed ID: 16403441	2006
Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia. Radiation research\| PubMed ID: 16494518	2006
Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 16685254	2007
Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. European journal of radiology\| PubMed ID: 16716552	2006
Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas? European journal of radiology\| PubMed ID: 16766153	2006
Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation. Radiology\| PubMed ID: 16793983	2006
Noninvasive transesophageal cardiac thermal ablation using a 2-D focused, ultrasound phased array: a simulation study. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 16846146	2006
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16868082	2006
Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes. Biorheology\| PubMed ID: 16912400	2006
Simulations of localized harmonic motions on a blood vessel wall induced by an acoustic radiation force used in ultrasound elastography. Physics in medicine and biology\| PubMed ID: 16953044	2006
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. Journal of neurosurgery\| PubMed ID: 16961141	2006
Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier. Ultrasound in medicine & biology\| PubMed ID: 16965980	2006
Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology\| PubMed ID: 16990673	2006
Image-guided neurosurgery at Brigham and Women's Hospital. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society\| PubMed ID: 17020201	2006
Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study. Ultrasonic imaging\| PubMed ID: 17094690	2006
Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience. Medical physics\| PubMed ID: 17153409	2006
Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison. Ultrasound in medicine & biology\| PubMed ID: 17169704	2006
Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain. Expert opinion on drug delivery\| PubMed ID: 17184160	2007
Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2. Biochemical and biophysical research communications\| PubMed ID: 17188240	2007
Modular design for in vivo optical imaging and ultrasound treatment in the murine brain. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 17328340	2007
Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study. Ultrasound in medicine & biology\| PubMed ID: 17337109	2007
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. International journal of cancer. Journal international du cancer\| PubMed ID: 17437269	2007
A novel phase assignment protocol and driving system for a high-density focused ultrasound array. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 17441588	2007
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols. Radiology\| PubMed ID: 17446521	2007
Chemotherapy delivery issues in central nervous system malignancy: a reality check. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 17538176	2007
Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation. Biochemical and biophysical research communications\| PubMed ID: 17568561	2007
Clinical applications of focused ultrasound-the brain. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 17578343	2007
Cavitation threshold of microbubbles in gel tunnels by focused ultrasound. Ultrasound in medicine & biology\| PubMed ID: 17590501	2007
Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: a numerical study. Physics in medicine and biology\| PubMed ID: 17671344	2007
The effects of desiccation on skull bone sound speed in porcine models. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 17703676	2007
A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 17941383	2007
Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 18046702	2007
Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study. Physics in medicine and biology\| PubMed ID: 18065841	2007
Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging. IEEE transactions on medical imaging\| PubMed ID: 18092742	2007
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index. Ultrasound in medicine & biology\| PubMed ID: 18207311	2008
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. Ultrasound in medicine & biology\| PubMed ID: 18294757	2008
Fetal thermal effects of diagnostic ultrasound. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine\| PubMed ID: 18359908	2008
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. Ultrasound in medicine & biology\| PubMed ID: 18378064	2008
Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. PloS one\| PubMed ID: 18478109	2008
Ultrasound for drug and gene delivery to the brain. Advanced drug delivery reviews\| PubMed ID: 18486271	2008
Progress and problems in the application of focused ultrasound for blood-brain barrier disruption. Ultrasonics\| PubMed ID: 18511095	2008
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success. Radiology\| PubMed ID: 18695211	2008
Simulations of lesion detection using a combined phased array LHMI-technique. Ultrasonics\| PubMed ID: 18778843	2008
In vivo monitoring of focused ultrasound surgery using local harmonic motion. Ultrasound in medicine & biology\| PubMed ID: 18805626	2009
Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 18821603	2008
Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound. Biorheology\| PubMed ID: 18836235	2008
Macromolecular delivery across the blood-brain barrier. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19085123	2009
Transcranial shear-mode ultrasound: assessment of imaging performance and excitation techniques. IEEE transactions on medical imaging\| PubMed ID: 19150789	2009
MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 19161196	2009
Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 19411214	2009
New design for an endoesophageal sector- based array for the treatment of atrial fibrillation: a parametric simulation study. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 19411218	2009
Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion. Physics in medicine and biology\| PubMed ID: 19436103	2009
An MRI-compatible system for focused ultrasound experiments in small animal models. Medical physics\| PubMed ID: 19544806	2009
MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking. Medical physics\| PubMed ID: 19610290	2009
Focused ultrasound effects on nerve action potential in vitro. Ultrasound in medicine & biology\| PubMed ID: 19647923	2009
Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy. IEEE transactions on bio-medical engineering\| PubMed ID: 19695987	2010
MRI-guided focused ultrasound treatments. Ultrasonics\| PubMed ID: 19818981	2010
Local harmonic motion monitoring of focused ultrasound surgery--a simulation model. IEEE transactions on bio-medical engineering\| PubMed ID: 19822463	2010
Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery\| PubMed ID: 20087132	2010
Hyperthermia classic commentary: 'A scanned, focused, multiple transducer ultrasonic system for localised hyperthermia treatments', by K. Hynynen, R. Roemer, D. Anhalt, et al., International... International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 20100047	2010
Temperature change near microbubbles within a capillary network during focused ultrasound. Physics in medicine and biology\| PubMed ID: 20164536	2010
Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells. Bone\| PubMed ID: 20435172	2010
Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound. Ultrasound in medicine & biology\| PubMed ID: 20447757	2010
Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. PloS one\| PubMed ID: 20485502	2010
A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy. IEEE transactions on bio-medical engineering\| PubMed ID: 20515709	2010
Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. ACS chemical neuroscience\| PubMed ID: 20563295	2010
In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy. Physics in medicine and biology\| PubMed ID: 20693614	2010
The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model. Physics in medicine and biology\| PubMed ID: 20720286	2010
Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153. Cancer\| PubMed ID: 20886629	2011
Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. BMC neurology\| PubMed ID: 21078165	2010
Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls. Physics in medicine and biology\| PubMed ID: 21149950	2011
Localised drug release using MRI-controlled focused ultrasound hyperthermia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 21158487	2011
MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21279624	2011
Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate. Ultrasound in medicine & biology\| PubMed ID: 21376455	2011
Focused ultrasound surgery in oncology: overview and principles. Radiology\| PubMed ID: 21436096	2011
Two-photon fluorescence microscopy study of cerebrovascular dynamics in ultrasound-induced blood-brain barrier opening. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21505473	2011
Localized harmonic motion imaging for focused ultrasound surgery targeting. Ultrasound in medicine & biology\| PubMed ID: 21683514	2011
Simulations and measurements of transcranial low-frequency ultrasound therapy: skull-base heating and effective area of treatment. Physics in medicine and biology\| PubMed ID: 21734333	2011
The utility of sparse 2D fully electronically steerable focused ultrasound phased arrays for thermal surgery: a simulation study. Physics in medicine and biology\| PubMed ID: 21772081	2011
Ultrafast 1D MR thermometry using phase or frequency mapping. Magma (New York, N.Y.)\| PubMed ID: 21800192	2012
Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies. Ultrasound in medicine & biology\| PubMed ID: 21925788	2011
Investigation of standing-wave formation in a human skull for a clinical prototype of a large-aperture, transcranial MR-guided focused ultrasound (MRgFUS) phased array: an experimental and s... IEEE transactions on bio-medical engineering\| PubMed ID: 22049360	2012
Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. PloS one\| PubMed ID: 22114718	2011
Pulsed focused ultrasound-induced displacements in confined in vitro blood clots. IEEE transactions on bio-medical engineering\| PubMed ID: 22194235	2012
Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology. Neurosurgical focus\| PubMed ID: 22208896	2012
Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions-based Controller. Radiology\| PubMed ID: 22332065	2012
Hyperthermia in Bone Generated with MR Imaging-controlled Focused Ultrasound: Control Strategies and Drug Delivery. Radiology\| PubMed ID: 22344400	2012
Driving circuitry for focused ultrasound noninvasive surgery and drug delivery applications. Sensors (Basel, Switzerland)\| PubMed ID: 22346589	2011
Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 22349099	2012
In Vitro and In Vivo High-Intensity Focused Ultrasound Thrombolysis. Investigative radiology\| PubMed ID: 22373533	2012
Hyperthermia in bone generated with MR imaging-controlled focused ultrasound: control strategies and drug delivery. Radiology\| PubMed ID: 22438444	2012
Overview of therapeutic ultrasound applications and safety considerations. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine\| PubMed ID: 22441920	2012
Ultrasound enhanced drug delivery to the brain and central nervous system. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 22621739	2012
The design of a focused ultrasound transducer array for the treatment of stroke: a simulation study. Physics in medicine and biology\| PubMed ID: 22800986	2012
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound in medicine & biology\| PubMed ID: 22818878	2012
Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. Human gene therapy\| PubMed ID: 22838844	2012
High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke. PloS one\| PubMed ID: 22870315	2012
MRIgHIFU: a tool for image-guided therapeutics. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 22896850	2011
Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22921802	2012
Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 23153219	2012
Contrast-enhanced transcranial two-dimensional ultrasound imaging using shear-mode conversion at low frequency. Ultrasound in medicine & biology\| PubMed ID: 23245822	2013
Antitumor effects of combining docetaxel (taxotere) with the antivascular action of ultrasound stimulated microbubbles. PloS one\| PubMed ID: 23284980	2012
Focused ultrasound delivers targeted immune cells to metastatic brain tumors. Cancer research\| PubMed ID: 23302230	2013
Noninvasive and targeted drug delivery to the brain using focused ultrasound. ACS chemical neuroscience\| PubMed ID: 23379618	2013
Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound. Neuro-oncology\| PubMed ID: 23640533	2013
Amyloid-Î² plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound. Experimental neurology\| PubMed ID: 23707300	2013
Creating brain lesions with low-intensity focused ultrasound with microbubbles: a rat study at half a megahertz. Ultrasound in medicine & biology\| PubMed ID: 23743099	2013
Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration corrections: a simulation study. Physics in medicine and biology\| PubMed ID: 23807573	2013
Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24008151	2013
Cavitation-based third ventriculostomy using MRI-guided focused ultrasound. Journal of neurosurgery\| PubMed ID: 24074494	2013
The evaluation of steerable ultrasonic catheters for minimally invasive MRI-guided cardiac ablation. Magnetic resonance in medicine\| PubMed ID: 24114767	2014
A super-resolution ultrasound method for brain vascular mapping. Medical physics\| PubMed ID: 24320408	2013
The application of sparse arrays in high frequency transcranial focused ultrasound therapy: a simulation study. Medical physics\| PubMed ID: 24320540	2013
Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 24374363	2014
Numerical simulations of clinical focused ultrasound functional neurosurgery. Physics in medicine and biology\| PubMed ID: 24619067	2014
Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice. Brain stimulation\| PubMed ID: 24629831	2014
Drug delivery across the blood-brain barrier using focused ultrasound. Expert opinion on drug delivery\| PubMed ID: 24650132	2014
Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array. IEEE transactions on bio-medical engineering\| PubMed ID: 24658252	2014
Intracranial applications of magnetic resonance-guided focused ultrasound. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 24850310	2014
A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles. Journal of neuroscience methods\| PubMed ID: 24970578	2014
Simulation study of the effects of near- and far-field heating during focused ultrasound uterine fibroid ablation using an electronically focused phased array: A theoretical analysis of pati... Medical physics\| PubMed ID: 24989412	2014
High-intensity focused ultrasound sonothrombolysis: the use of perfluorocarbon droplets to achieve clot lysis at reduced acoustic power. Ultrasound in medicine & biology\| PubMed ID: 25023095	2014
Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25107692	2014
Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology\| PubMed ID: 25222068	2014
Modeling localized delivery of Doxorubicin to the brain following focused ultrasound enhanced blood-brain barrier permeability. Physics in medicine and biology\| PubMed ID: 25230100	2014
Microbubbles and blood-brain barrier opening: a numerical study on acoustic emissions and wall stress predictions. IEEE transactions on bio-medical engineering\| PubMed ID: 25546853	2015
Hyperthermia-mediated doxorubicin release from thermosensitive liposomes using MR-HIFU: therapeutic effect in rabbit Vx2 tumours. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 25582131	2015
A novel, flat, electronically-steered phased array transducer for tissue ablation: preliminary results. Physics in medicine and biology\| PubMed ID: 25683789	2015
Gene delivery to the spinal cord using MRI-guided focused ultrasound. Gene therapy\| PubMed ID: 25781651	2015
Emerging non-cancer applications of therapeutic ultrasound. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 25792225	2015
Focused ultrasound-mediated drug delivery through the blood-brain barrier. Expert review of neurotherapeutics\| PubMed ID: 25936845	2015
Quantitative MRI in a non-surgical model of cervical spinal cord injury. NMR in biomedicine\| PubMed ID: 26053102	2015
Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections. Medical physics\| PubMed ID: 26133635	2015
Frequency considerations for deep ablation with high-intensity focused ultrasound: A simulation study. Medical physics\| PubMed ID: 26233216	2015
Combined Therapeutic and Monitoring Ultrasonic Catheter for Cardiac Ablation Therapies. Ultrasound in medicine & biology\| PubMed ID: 26431798	2016
Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System. Advances in experimental medicine and biology\| PubMed ID: 26486344	2016
Comparison of analytical and numerical approaches for CT-based aberration correction in transcranial passive acoustic imaging. Physics in medicine and biology\| PubMed ID: 26605827	2016
A review of ablative techniques in the treatment of breast fibroadenomata. Journal of therapeutic ultrasound\| PubMed ID: 26788322	2016
Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival. Neuro-oncology\| PubMed ID: 26819443	2016
Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound. Neuropharmacology\| PubMed ID: 26907805	2017
Magnetic resonance-guided high-intensity focused ultrasound combined with radiotherapy for palliation of head and neck cancer-a pilot study. Journal of therapeutic ultrasound\| PubMed ID: 27042308	2016
Magnetic Resonance-Guided High-Intensity Focused Ultrasound Hyperthermia for Recurrent Rectal Cancer: MR Thermometry Evaluation and Preclinical Validation. International journal of radiation oncology, biology, physics\| PubMed ID: 27209510	2016
Opening the Blood-Brain Barrier with MR Imaging-guided Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Porcine Model. Radiology\| PubMed ID: 27420647	2017
Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability. PloS one\| PubMed ID: 27459643	2016
Magnetic Resonance-Guided High-Intensity-Focused Ultrasound for Palliation of Painful Skeletal Metastases: A Pilot Study. Technology in cancer research & treatment\| PubMed ID: 27480322	2017
Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy. Physics in medicine and biology\| PubMed ID: 27494561	2016
A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor. The New England journal of medicine\| PubMed ID: 27557301	2016
Registration of human skull computed tomography data to an ultrasound treatment space using a sparse high frequency ultrasound hemispherical array. Medical physics\| PubMed ID: 27587036	2016
A numerical study on the oblique focus in MR-guided transcranial focused ultrasound. Physics in medicine and biology\| PubMed ID: 27779134	2016
A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping. Physics in medicine and biology\| PubMed ID: 27845920	2016
A Tikhonov Regularization Scheme for Focus Rotations With Focused Ultrasound-Phased Arrays. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 27913323	2016
Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine\| PubMed ID: 28108988	2017
To heat or not to heat: Challenges with clinical translation of thermosensitive liposomes. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28122204	2017
Urinary cytokines/chemokines after magnetic resonance-guided high intensity focused ultrasound for palliative treatment of painful bone metastases. Annals of palliative medicine\| PubMed ID: 28209068	2017
Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome. Scientific reports\| PubMed ID: 28374753	2017
Focused ultrasound as a novel strategy for Alzheimer disease therapeutics. Annals of neurology\| PubMed ID: 28395123	2017
A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound. BMC neurology\| PubMed ID: 28412948	2017
Design of a HIFU array for the treatment of deep venous thrombosis: a simulation study. Physics in medicine and biology\| PubMed ID: 28486218	2017
Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range. Physics in medicine and biology\| PubMed ID: 28665289	2017
A viscoelastic model for the prediction of transcranial ultrasound propagation: application for the estimation of shear acoustic properties in the human skull. Physics in medicine and biology\| PubMed ID: 28783716	2017
Megahertz rate, volumetric imaging of bubble clouds in sonothrombolysis using a sparse hemispherical receiver array. Physics in medicine and biology\| PubMed ID: 28786395	2017
Focused Ultrasound Hyperthermia Mediated Drug Delivery Using Thermosensitive Liposomes and Visualized With Two-Photon Microscopy. Theranostics\| PubMed ID: 28819458	2017
Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics\| PubMed ID: 28912896	2017
Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease. Brain research\| PubMed ID: 29066368	2018
Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose. Theranostics\| PubMed ID: 29109793	2017
Antidepressant effects of focused ultrasound induced blood-brain-barrier opening. Behavioural brain research\| PubMed ID: 29326057	2018
Reply to Kovacs .: Concerning acute inflammatory response following focused ultrasound and microbubbles in the brain. Theranostics\| PubMed ID: 29722372	2018
Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures. Journal of neurosurgery\| PubMed ID: 29726769	2018
Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 29753957	2018
The reduction in treatment efficiency at high acoustic powers during MR-guided transcranial focused ultrasound thalamotomy for Essential Tremor. Medical physics\| PubMed ID: 29758099	2018
An MR-based quantitative intraventricular hemorrhage porcine model for MR-guided focused ultrasound thrombolysis. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery\| PubMed ID: 29796753	2018
Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening. Theranostics\| PubMed ID: 29896293	2018
Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases. Scientific reports\| PubMed ID: 29899537	2018
Microbubble Localization for Three-Dimensional Superresolution Ultrasound Imaging Using Curve Fitting and Deconvolution Methods. IEEE transactions on bio-medical engineering\| PubMed ID: 29993387	2018
Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nature communications\| PubMed ID: 30046032	2018
Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30051428	2018
Predicting lesion size by accumulated thermal dose in MR-guided focused ultrasound for essential tremor. Medical physics\| PubMed ID: 30098027	2018
Angiogenic response of rat hippocampal vasculature to focused ultrasound-mediated increases in blood-brain barrier permeability. Scientific reports\| PubMed ID: 30111814	2018
Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease. Scientific reports\| PubMed ID: 30232364	2018
Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 30264465	2018
Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 30288794	2018
Microbubble-assisted MRI-guided focused ultrasound for hyperthermia at reduced power levels. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 30295119	2018
Enhancing Checkpoint Inhibitor Therapy with Ultrasound Stimulated Microbubbles. Ultrasound in medicine & biology\| PubMed ID: 30447880	2019
Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor. Brain : a journal of neurology\| PubMed ID: 30452554	2018
Receiver array design for sonothrombolysis treatment monitoring in deep vein thrombosis. Physics in medicine and biology\| PubMed ID: 30484436	2018
Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability. The British journal of radiology\| PubMed ID: 30507302	2019
Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability. Expert opinion on drug delivery\| PubMed ID: 30628455	2019
Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study. Scientific reports\| PubMed ID: 30674905	2019
MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30783974	2019
Hyperthermia-induced drug delivery in humans. Nature biomedical engineering\| PubMed ID: 31015680	2018
The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound. Journal of neurosurgery\| PubMed ID: 31051458	2019
Accumulated thermal dose in MRI-guided focused ultrasound for essential tremor: repeated sonications with low focal temperatures. Journal of neurosurgery\| PubMed ID: 31075781	2019
Acoustic radiation force induced accumulation and dynamics of microbubbles on compliant surfaces. Physics in medicine and biology\| PubMed ID: 31082815	2019
Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease. NeuroImage\| PubMed ID: 31254646	2019
Transcranial Photoacoustic Detection of Blood-Brain Barrier Disruption Following Focused Ultrasound-Mediated Nanoparticle Delivery. Molecular imaging and biology\| PubMed ID: 31286352	2020
MR-guided Focused Ultrasound Facilitates Sonodynamic Therapy with 5-Aminolevulinic Acid in a Rat Glioma Model. Scientific reports\| PubMed ID: 31320671	2019
Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 31326464	2019
Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans. Annals of neurology\| PubMed ID: 31525269	2019
First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nature communications\| PubMed ID: 31558719	2019
Tractography-based targeting of the ventral intermediate nucleus: accuracy and clinical utility in MRgFUS thalamotomy. Journal of neurosurgery\| PubMed ID: 31561221	2019
Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease. Theranostics\| PubMed ID: 31754385	2019
Super-resolution Ultrasound Imaging. Ultrasound in medicine & biology\| PubMed ID: 31973952	2020
A Noninvasive Ultrasound Resonance Method for Detecting Skull Induced Phase Shifts May Provide a Signal for Adaptive Focusing. IEEE transactions on bio-medical engineering\| PubMed ID: 31976875	2020
Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure. Theranostics\| PubMed ID: 32042325	2020
Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery. Ultrasound in medicine & biology\| PubMed ID: 32165014
Localized anesthesia of a specific brain region using ultrasound-responsive barbiturate nanodroplets. Theranostics\| PubMed ID: 32194839	2020
Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia. Theranostics\| PubMed ID: 32194850	2020
Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation. Nano letters\| PubMed ID: 32374617	2020
Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials. Molecular psychiatry\| PubMed ID: 32404942	2020
Ultrafast three-dimensional microbubble imaging predicts tissue damage volume distributions during nonthermal brain ablation. Theranostics\| PubMed ID: 32641988	2020
Echo-Focusing in Transcranial Focused Ultrasound Thalamotomy for Essential Tremor: A Feasibility Study. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 32815611	2020
Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs. Science advances\| PubMed ID: 32917589	2020
Technical and radiographic considerations for magnetic resonance imaging-guided focused ultrasound capsulotomy. Journal of neurosurgery\| PubMed ID: 32977311	2020
Comparing rapid short-pulse to tone burst sonication sequences for focused ultrasound and microbubble-mediated blood-brain barrier permeability enhancement. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 33022327	2021
Applications of focused ultrasound in the brain: from thermoablation to drug delivery. Nature reviews. Neurology\| PubMed ID: 33106619	2021
MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 33188825	2021
Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior. eLife\| PubMed ID: 33236981	2020
Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33288687	2020
Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain. Scientific reports\| PubMed ID: 33299094	2020
Technical Principles and Clinical Workflow of Transcranial MR-Guided Focused Ultrasound. Stereotactic and functional neurosurgery\| PubMed ID: 33302282	2021
Perfusion fixation methods for preclinical biodistribution studies: A comparative assessment using automated image processing. Methods and applications in fluorescence\| PubMed ID: 33316782	2021
Focused Ultrasound and Microbubbles-Mediated Drug Delivery to Brain Tumor. Pharmaceutics\| PubMed ID: 33374205	2020
Vasculotide restores the blood-brain barrier after focused ultrasound-induced permeability in a mouse model of Alzheimer's disease. International journal of medical sciences\| PubMed ID: 33390817	2021
Neutrophil recruitment and leukocyte response following focused ultrasound and microbubble mediated blood-brain barrier treatments. Theranostics\| PubMed ID: 33408773	2021
Novel Treatment Approaches for Brain Tumour from a Blood-Brain Barrier Perspective. Handbook of experimental pharmacology\| PubMed ID: 33454856	2021
Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery. Scientific reports\| PubMed ID: 33479314	2021
Ultrasound-sensitive nanodroplets achieve targeted neuromodulation. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 33600879	2021
MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors. Neuro-oncology\| PubMed ID: 33693781	2021
Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound. Annual review of biomedical engineering\| PubMed ID: 33752471	2021
Corrigendum: Perfusion fixation methods for preclinical biodistribution studies: a comparative assessment using automated image processing (2021 017001). Methods and applications in fluorescence\| PubMed ID: 34110305	2021
Erratum: "Registration of human skull computed tomography data to an ultrasound treatment space using a sparse high frequency ultrasound hemispherical array" [Med. Phys. 43, 5063-5071 (2016)... Medical physics\| PubMed ID: 34235769	2021
The mechanical potential of ultrasound on nervous tissue. The Journal of the Acoustical Society of America\| PubMed ID: 34241452	2021
Intravenous and Non-invasive Drug Delivery to the Mouse Basal ForebrainUsing MRI-guided Focused Ultrasound. Bio-protocol\| PubMed ID: 34262999	2021
Focused ultrasound neuromodulation. International review of neurobiology\| PubMed ID: 34446247	2021
Sub-millimetre precision of drug delivery in the brain from ultrasound-triggered nanodroplets. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 34530050	2021
Comparison of computer simulations and clinical treatment results of magnetic resonance guided focused ultrasound surgery (MRgFUS) of uterine fibroids. Medical physics\| PubMed ID: 34601729	2021
MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases. Science translational medicine\| PubMed ID: 34644145	2021
Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis. Molecular therapy. Methods & clinical development\| PubMed ID: 34761053	2021
Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. Brain : a journal of neurology\| PubMed ID: 34919633	2021
Targeted Nanoparticle for Co-delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 35083840	2022