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Journal / Bioengineering / Real-Time Intravital Multiphoton Microscopy to…
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Bioengineering
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JoVE Journal Bioengineering
Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
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Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

Article DOI: 10.3791/62235-v • 06:29 min • February 5th, 2022
February 5th, 2022 •
1,2, *3, *3, 4,5, 3, 1,2,6
1Physical Sciences Platform, Sunnybrook Research Institute, 2Institute of Biomedical Engineering, University of Toronto, 3Department of Physics, Norwegian University of Science and Technology, 4Department of Clinical Medicine, University of Bergen, 5Exact Therapeutics AS, 6Department of Medical Biophysics, University of Toronto
* These authors contributed equally

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Summary
Automatic Translation

This protocol describes the surgical and technical procedures that enable real-time in vivo multiphoton fluorescence imaging of the rodent brain during focused ultrasound and microbubble treatments to increase blood-brain barrier permeability.

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Real-Time Intravital Multiphoton Microscopy Focused Ultrasound Microbubble Treatments Blood-Brain Barrier Permeability Ultrasound Exposure Microbubbles Drug Delivery Brain Diseases Tight Junctions Contrast-enhanced Magnetic Resonance Imaging Dye Extravasation Real-time Response Intravital Multiphoton Imaging Cranial Window Surgery Ultrasound Microbubble Treatment
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