interphase-fluorescence-situ-hybridization-bone-marrow-smears

Interphase Fluorescence <em>in situ</em> Hybridization of Bone Marrow Smears of Multiple Myeloma

Fluorescence in situ hybridization (FISH) detection is an indispensable method in genetic risk stratification in multiple myeloma (MM), which is one of ...

zhongnan hospital of Wuhan University

Huazhong University of Science and Technology

MicroRNAs (miRNAs) are small noncoding RNAs approximately 20-25 nt in length, which play crucial roles through directly binding to corresponding 3' UTR of targeted mRNAs. It has been reported that miRNAs are involved in numerous of diseases, including cancers. Recently, miR-134 has been identified to dysregulate in handles of human cancers, such as lung cancer, glioma, breast cancer, colorectal cancer, and so on. Increasing evidence indicates that miR-134 is essential for human carcinoma and participates in tumor cell proliferation, apoptosis, invasion and metastasis, drug resistance, as well as cancer diagnosis, treatment, and prognosis. Nevertheless, its roles in human cancer are still ambiguous, and its mechanisms are sophisticated as well, referring to a variety of targets and signal pathways, such as STAT5B, KRAS, MAPK/ERK signal pathway, Notch pathway, etc. Herein, we review the crucial roles of miR-134 in scores of human cancers via analyzing latest investigations, which might provide evidence for cancer diagnose, treatment, prognosis, or further investigations.

miR-134: A Human Cancer Suppressor?

To provide clinical management guidelines for novel coronavirus (COVID-19) in pregnancy.

Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection.

Measures for preventing nosocomial infection with SARS-CoV-2 in hematology departments.

To understand about the experiences and feelings of the nurses infected with COVID-19 when caring for patients with COVID-19.

Article	Year
miR-134: A Human Cancer Suppressor? Molecular therapy. Nucleic acids\| PubMed ID: 28325280	2017
Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics\| PubMed ID: 32196655	2020
Measures for preventing nosocomial infection with SARS-CoV-2 in hematology departments. Annals of hematology\| PubMed ID: 32601797	2020
The experiences of nurses infected with COVID-19 in Wuhan, China: A qualitative study. Journal of nursing management\| PubMed ID: 33480116	2021
A new workflow on bone marrow aspiration and biopsy during the COVID-19 pandemic. Archives of medical science : AMS\| PubMed ID: 34522274	2021

Jing He

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