a-rodent-model-ross-operation-syngeneic-pulmonary-artery-graft

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

The Ross operation for aortic valve disease has regained new interest due to its outstanding long-term results. Nonetheless, when employed as freestanding ...

University of Padua

The pandemic of Novel Coronavirus Disease 2019 (COVID-19) is challenging, given the large number of hospitalized patients. Cardiovascular co-morbidities are linked to a higher mortality risk. Thus, patients with Congenital Heart Disease (CHD) might represent a high-risk population. Nevertheless, no data about them are available, yet. Hence, we conducted a nationwide survey to assess clinical characteristics and outcomes in patients with congenital heart disease affected by COVID-19.

COVID-19 and Congenital Heart Disease: Results from a Nationwide Survey.

Pulmonary regurgitation (PR) and right ventricular (RV) dilatation and disfunction are common in patients with repaired Tetralogy of Fallot (r-TOF).

Echocardiography and cardiac magnetic resonance in children with repaired tetralogy of Fallot: New insights in cardiac mechanics and exercise capacity.

The ongoing pandemic of Novel Coronavirus Disease 2019 (COVID-19) infection has created a global emergency. Despite the infection causes a mild illness to most people, some patients are severely affected, demanding an urgent need to better understand how to risk-stratify infected subjects.

Impact of cardiovascular risk profile on COVID-19 outcome. A meta-analysis.

The pandemic of Novel Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has provoked hundreds of thousands of deaths, resulting in catastrophe for humans. Although some insights have been garnered in studies on women, children and young adults infected with COVID-19, these often remain fragmented in literature. Therefore, we discussed the impact of COVID-19 pandemic on women, children and young patients, particularly those with underlying cardiovascular comorbidities or congenital heart disease. Furthermore, we gathered and distilled the existing body of literature that describes their cardiovascular complications and the recommended actions in favour of those patients toward the post-peak pandemic period. Although many questions still require answers, this article is sought to help the practicing clinician in the understanding and management of the threatening disease in special populations.

Women's perspective on the COVID-19 pandemic: Walking into a post-peak phase.

During ischemia a close relationship exists between sub-endocardial blood flow and myocardial function. Strain parameters can capture an impairment of regional longitudinal function but are load dependent. Recently, a novel non-invasive method to calculate Myocardial Work (MW) showed a strong correlation with invasive work measurements. Our aim was to investigate the ability of non-invasive MW indices to identify the ischaemic risk area during transient acute coronary occlusion (TACO).

Non-invasive myocardial work is reduced during transient acute coronary occlusion.

The tricuspid valve (TV) has been neglected for many years. Only recently, new studies demonstrated the prognostic role of the tricuspid valve lesions. In addition to that, new interventional approaches offer the possibility to non-invasively treat tricuspid valve disease. In this review, our aim is to summarize the role of different imaging techniques in the assessment of tricuspid valve with particular regards to congenital heart diseases. Finally, we analyze the importance of the TV and its adjacent regions from an electrophysiological point of view, both in structurally normal hearts and in congenital heart diseases. The most relevant transthoracic echocardiography (TTE) views to visualize the TV are the "modified" parasternal long axis, the apical views and subcostal projections, such as right oblique or left oblique views. However, simultaneous visualization of the three leaflets is possible only with three-dimensional TTE, or, sometimes, in parasternal short axis and subcostal short axis views in children. 3D echocardiography (3DE) is promising in this field. Indeed, its unique projections, such as en face views from the right ventricular and atrial perspectives, are able to define the spatial relationship of the tricuspid leaflets with the surrounding structures. Moreover, multimodality imaging assessment has been recently proposed for the diagnostic assessment of the TV, especially before percutaneous intervention. Cardiac Computed Tomography (CCT) provides valuable anatomic spatial information of the TV apparatus. Cardiac Magnetic Resonance (CMR) is able to provide, non-invasively, detailed morphological and functional information of the valve.

Tricuspid valve in congenital heart disease: multimodality imaging and electrophysiological considerations.

How to measure left ventricular twist by two-dimensional speckle-tracking analysis.

 Non-invasive prediction of critical coronary artery stenosis (CAST) in patients with coronary artery disease (CAD) is challenging. Strain parameters can often capture an impairment of regional longitudinal function; however, they are load dependent. A novel non-invasive method to estimate Myocardial Work (MW) has been recently proposed, showing a strong correlation with invasive work measurements. Our aim was to investigate the ability of non-invasive MW to predict the ischaemic risk area underlying a CAST.  The study population comprises 80 individuals: 50 patients with CAST and 30 controls (CTRL). Echocardiography recordings were obtained before coronary angiography to measure global longitudinal strain (GLS), Myocardial Work Index (MWI), Myocardial Constructive Work (MCW), Myocardial Wasted work (MWW), Myocardial Work Efficiency (MWE). Global MWI ( = 0.048), MWE ( < 0.001), and MCW ( = 0.048) at baseline were significantly reduced in patients with CAST compared to controls ( < 0.05). Regional MWE within the myocardial segments underlying the CAST, but not LS, was significantly reduced compared to non-target segments ( < 0.001). At ROC analysis, the diagnostic performance to predict CAST for regional MWE (AUC = 0.920,  < 0.001) was higher compared to both regional post-systolic shortening index (PSI) (AUC = 0.600,  = 0.129) and regional LS (AUC = 0.546,  = 0.469).  Non-invasive estimation of MW work indices is able to predict a CAST before invasive angiography.

Article	Year
COVID-19 and Congenital Heart Disease: Results from a Nationwide Survey. Journal of clinical medicine\| PubMed ID: 32521643	2020
Echocardiography and cardiac magnetic resonance in children with repaired tetralogy of Fallot: New insights in cardiac mechanics and exercise capacity. International journal of cardiology\| PubMed ID: 32702408	2020
Impact of cardiovascular risk profile on COVID-19 outcome. A meta-analysis. PloS one\| PubMed ID: 32797054	2020
Women's perspective on the COVID-19 pandemic: Walking into a post-peak phase. International journal of cardiology\| PubMed ID: 32800917	2021
Non-invasive myocardial work is reduced during transient acute coronary occlusion. PloS one\| PubMed ID: 33370359	2020
Tricuspid valve in congenital heart disease: multimodality imaging and electrophysiological considerations. Minerva cardiology and angiology\| PubMed ID: 33944535	2021
How to measure left ventricular twist by two-dimensional speckle-tracking analysis. European heart journal. Cardiovascular Imaging\| PubMed ID: 34160033	2021
Prediction of Significant Coronary Artery Disease Through Advanced Echocardiography: Role of Non-invasive Myocardial Work. Frontiers in cardiovascular medicine\| PubMed ID: 34504879	2021
The new pandemic: ACHD HF. International journal of cardiology\| PubMed ID: 35288196	2022

Jolanda Sabatino

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