A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

Arben Dedja; Claudia Cattapan; Giovanni Di Salvo; Martina Avesani; Jolanda Sabatino; Alvise Guariento; Vladimiro Vida

doi:10.3791/63179

Journal

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Medicine

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A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

JoVE Journal
Medicine
Author Produced

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JoVE Journal Medicine

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

3,026 Views

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11:20 min

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April 01, 2022

DOI:

10.3791/63179-v

DOI:

10.3791/63179-v

•

11:20 min

April 01, 2022

•

3019 Views

Arben Dedja*¹, Claudia Cattapan*¹, Giovanni Di Salvo², Martina Avesani², Jolanda Sabatino², Alvise Guariento^1,3, Vladimiro Vida¹

¹Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health,University of Padua ²Pediatric Cardiology Unit, Departments of Women’s and Children’s Health,University of Padua ³Labatt Family Heart Centre, Department of Cardiovascular Surgery, The Hospital for Sick Children,University of Toronto

Summary

We demonstrate how to establish a murine model of pulmonary root implantation into the descending aorta to simulate the Ross procedure. This model enables the medium/long-term evaluation of pulmonary autograft remodeling in a systemic position, representing the basis of developing therapeutic strategies to promote its adaptation.