application-optical-coherence-tomography-to-mouse-model

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Optical coherence tomography (OCT) offers a noninvasive method for the diagnosis of retinopathy. The OCT machine can capture retinal crosssectional images ...

scanning-electron-microscopy-energy-dispersive-spectroscopy

Scanning Electron Microscopy-Energy Dispersive Spectroscopy Evaluation of a Retinal Explant Model of Iron Intraocular Foreign Body Injury

Iron intraocular foreign body (IOFB) can cause retinal damage, which may be related to the release, transfer, and tissue infiltration of iron particles. ...

Shantou University and the Chinese University of Hong Kong

Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong

Gansu Provincial Hospital

 This study aims to investigate the correlation between electroretinogram (ERG) and visual outcome in eyes with metallic intraocular foreign body (IOFB) injury.  Cases with metallic IOFB injuries with preoperative ERG from January 2008 to May 2020 were reviewed retrospectively. Five ERG responses were recorded, including rod response, maximal response, oscillatory potentials, cone response, and 30-Hz flicker. The results were compared between the affected and the contralateral eyes. All patients received surgery to remove IOFBs. The correlation between amplitudes, implicit times, and grades of ERG with final best-corrected visual acuity (BCVA) was analyzed.  A total of 33 eyes of 33 patients were included. The eyes with IOFB had generally delayed implicit time and reduced amplitude in all waves. The maximum change was found in oscillatory potentials S3 and N1 (0.42 ± 0.42 and 1.95 ± 1.97 of the fellow eyes, respectively,  < 0.05). All amplitudes were negatively correlated with the final BCVA (rs: -0.676 to -0.459, all  < 0.05). In contrast, all implicit times were positively correlated with final BCVA, although, some of them were not statistically significant (rs: 0.035 to 0.687). Among them, oscillatory potential P3 has the highest correlation coefficient (rs = 0.687,  < 0.001). All grades of ERG waves were statistically correlated with the final BCVA (rs: -0.596 to -0.664, all  < 0.001).  ERG can be used to assess visual outcome in metallic IOFB injury after surgery. Oscillatory potentials provided the most significant responses.

Correlation Between Electroretinogram and Visual Prognosis in Metallic Intraocular Foreign Body Injury.

Retinitis pigmentosa (RP) belongs to a group of inherited retinal diseases with high genetic heterogeneity. This study aimed at identifying the disease-causing variants in patients with autosomal recessive RP.

Whole exome sequencing reveals novel  mutations in Chinese patients with autosomal recessive retinitis pigmentosa.

To investigate the topographic characters of inter-individual variations of the macular choroidal thickness (CT).

ArticleTotal : 2	Year
Publication title Cited by 2	2022
Publication title	2026

Article	Year
Correlation Between Electroretinogram and Visual Prognosis in Metallic Intraocular Foreign Body Injury. Frontiers in medicine\| PubMed ID: 34249977	2021
Whole exome sequencing reveals novel mutations in Chinese patients with autosomal recessive retinitis pigmentosa. Molecular vision\| PubMed ID: 30804660	2019
Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography. Translational vision science & technology\| PubMed ID: 38630469	2024

Xiaoting Mai

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