Jeremy C. Simpson

Cell Screening Laboratory, University College Dublin

Affiliated withUniversity College Dublin University College Dublin

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2021

Other Publications

Article	Year
Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway. Seminars in cell & developmental biology\| PubMed ID: 19660568	2009
Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. EMBO reports\| PubMed ID: 19745841	2009
Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line. Nanotoxicology\| PubMed ID: 21142842	2011
Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Molecular & cellular proteomics : MCP\| PubMed ID: 21778410	2011
Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images. BMC bioinformatics\| PubMed ID: 22017789	2011
High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells. ACS nano\| PubMed ID: 22276691	2012
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nature cell biology\| PubMed ID: 22660414	2012
A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients. BMC research notes\| PubMed ID: 22681635	2012
Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A. PloS one\| PubMed ID: 22973456	2012
Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells. Journal of nanobiotechnology\| PubMed ID: 23006133	2012
Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells. Biochemical Society transactions\| PubMed ID: 23176486	2012
Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc). PloS one\| PubMed ID: 23383136	2013
A real-time impedance based method to assess Rhodococcus equi virulence. PloS one\| PubMed ID: 23555995	2013
Human diseases associated with form and function of the Golgi complex. International journal of molecular sciences\| PubMed ID: 24025425	2013
Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles. Nanoscale\| PubMed ID: 24108393	2013
High-content screening and analysis of the Golgi complex. Methods in cell biology\| PubMed ID: 24295313	2013
RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells. Nanomedicine (London, England)\| PubMed ID: 24359549	2014
Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance. Molecular and cellular biology\| PubMed ID: 24636989	2014
Actin in action: imaging approaches to study cytoskeleton structure and function. Cells\| PubMed ID: 24709877	2013
HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways. Journal of proteome research\| PubMed ID: 24766643	2014
The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport. Biochemical Society transactions\| PubMed ID: 25233431	2014
Trajectory-based co-localization measures for nanoparticle-cell interaction studies. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25504742	2015
Biocompatibility of ferroelectric lithium niobate and the influence of polarization charge on osteoblast proliferation and function. Journal of biomedical materials research. Part A\| PubMed ID: 25504748	2015
Hydroxyapatite and fluorapatite coatings on dental screws: effects of blast coating process and biological response. Journal of materials science. Materials in medicine\| PubMed ID: 25578701	2015
A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways. Molecular & cellular proteomics : MCP\| PubMed ID: 25759509	2015
High-content analysis for drug delivery and nanoparticle applications. Drug discovery today\| PubMed ID: 25908578	2015
A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking. Journal of cell science\| PubMed ID: 25999475	2015
High-content analysis of Rab protein function at the ER-Golgi interface. Bioarchitecture\| PubMed ID: 26693811	2015
Implementation of the Rank-Weighted Co-localization (RWC) algorithm in multiple image analysis platforms for quantitative analysis of microscopy images. Source code for biology and medicine\| PubMed ID: 26884809	2016
Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time. Nature communications\| PubMed ID: 26927507	2016
A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells. Scientific reports\| PubMed ID: 27374232	2016
Genome-Wide siRNA Screening Using Forward Transfection: Identification of Modulators of Membrane Trafficking in Mammalian Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27581283	2016
Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology. Tissue & cell\| PubMed ID: 27720426	2017
Systematic functional analysis of the Ras GTPase family unveils a conserved network required for anterograde protein trafficking. Proteomics\| PubMed ID: 27957805	2017
Functional characterisation of the YIPF protein family in mammalian cells. Histochemistry and cell biology\| PubMed ID: 27999994	2017
Characterization of carboxylate nanoparticle adhesion with the fungal pathogen Candida albicans. Nanoscale\| PubMed ID: 29019498	2017
Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster. Journal of genetics and genomics = Yi chuan xue bao\| PubMed ID: 29037990	2017
Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches. Handbook of experimental pharmacology\| PubMed ID: 29071510	2018
Bioinspired Star-Shaped Poly(l-lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem Cells. Molecular pharmaceutics\| PubMed ID: 29590755	2018
Rapid Growth Cone Uptake and Dynein-Mediated Axonal Retrograde Transport of Negatively Charged Nanoparticles in Neurons Is Dependent on Size and Cell Type. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 30565853	2019
Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome. PloS one\| PubMed ID: 30689642	2019
A High-Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 31334922	2019
Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b. International journal of molecular sciences\| PubMed ID: 31408960	2019
The Challenges and Possibilities of Extracellular Vesicles as Therapeutic Vehicles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 31419585	2019
Rab35 controls cilium length, function and membrane composition. EMBO reports\| PubMed ID: 31432619	2019
NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases. Frontiers in neuroscience\| PubMed ID: 31680803	2019
Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni. Scientific reports\| PubMed ID: 31796849	2019
Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 32059764	2020
SCLpred-EMS: subcellular localization prediction of endomembrane system and secretory pathway proteins by Deep N-to-1 Convolutional Neural Networks. Bioinformatics (Oxford, England)\| PubMed ID: 32142105	2020
Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes. PeerJ\| PubMed ID: 32185116	2020
Modification of the Mammalian Endomembrane System in Healthy and Diseased Cells. International journal of molecular sciences\| PubMed ID: 32244909	2020
RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells. Cells\| PubMed ID: 32354068	2020
Emerging roles for Rho GTPases operating at the Golgi complex. Small GTPases\| PubMed ID: 32881632	2021
Antimicrobial effects of airborne acoustic ultrasound and plasma activated water from cold and thermal plasma systems on biofilms. Scientific reports\| PubMed ID: 33057158	2020
A novel high-content screening approach for the elucidation of C. jejuni biofilm composition and integrity. BMC microbiology\| PubMed ID: 33397288	2021
Inactivation efficacy of atmospheric air plasma and airborne acoustic ultrasound against bacterial biofilms. Scientific reports\| PubMed ID: 33504900	2021
A novel automated image analysis pipeline for quantifying morphological changes to the endoplasmic reticulum in cultured human cells. BMC bioinformatics\| PubMed ID: 34496765	2021
Multiparametric nanoparticle-induced toxicity readouts with single cell resolution in HepG2 multicellular tumour spheroids. Nanoscale\| PubMed ID: 34661590	2021
2D-GolgiTrack-a semi-automated tracking system to quantify morphological changes and dynamics of the Golgi apparatus and Golgi-derived membrane tubules. Medical & biological engineering & computing\| PubMed ID: 34783979	2021
Cell3: A new vision for study of the endomembrane system in mammalian cells. Bioscience reports\| PubMed ID: 34793591	2021
Cell3: a new vision for study of the endomembrane system in mammalian cells. Bioscience reports\| PubMed ID: 34874399	2021