Schuichi Koizumi

Department of Neuropharmacology, University of Yamanashi

Research Area

Biography

Dr Koizumi received his PhD at Kyushu University majored in Neuropharmacology, and then did posdoc in Health Science foundation in Japan (Prof Inoue), and in Cambridge University in UK (Prof Mike Berridge). He got a Researcher position in 1999 in National Institute of Health Sciences in Japan, and then got a Professor position in 2007 at Faculty of Medicine, Univ Yamanashi in Japan.

Dr Koizumi is interested in physiology and pathophysiology of glia-neuron interaction in relation to several brain diseases. In 2021, He established Yamanashi GLIA Centre in the university, and is a director of the Centre. He is also interested in ATP purinertic signalling, a pivotal mediator between glia and neurons. The current special interest is to clarify mechanisms underlying synapse formation and elimination mediated by astrocytes/microglia in many of pathophysiological conditions.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 9	2022
Publication title Cited by 3	2022

Other Publications

Article	Year
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature\| PubMed ID: 17410128	2007
Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. Journal of neurochemistry\| PubMed ID: 17662046	2007
The role of nucleotides in the neuron--glia communication responsible for the brain functions. Journal of neurochemistry\| PubMed ID: 17697046	2007
[Regulation of brain function mediated by glial ATP sensors]. Seikagaku. The Journal of Japanese Biochemical Society\| PubMed ID: 19260453	2009
Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms. Cellular and molecular neurobiology\| PubMed ID: 19381798	2009
Direct observation of ATP-induced conformational changes in single P2X(4) receptors. PLoS biology\| PubMed ID: 19419241	2009
The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. The Journal of biological chemistry\| PubMed ID: 19531473	2009
Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes. The FEBS journal\| PubMed ID: 19895581	2010
In vivo canine model comparison of cardiovascular effects of antidepressants milnacipran and imipramine. Cardiovascular toxicology\| PubMed ID: 20680703	2010
Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 21765041	2011
The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice. PloS one\| PubMed ID: 21876755	2011
Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. The Journal of clinical investigation\| PubMed ID: 22214844	2012
Cell-autonomous enhancement of glutamate-uptake by female astrocytes. Cellular and molecular neurobiology\| PubMed ID: 22450870	2012
Purinergic receptors in microglia: functional modal shifts of microglia mediated by P2 and P1 receptors. Glia\| PubMed ID: 22674620	2013
Purinergic signaling promotes proliferation of adult mouse subventricular zone cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22764232	2012
Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s). Cellular and molecular neurobiology\| PubMed ID: 22872320	2013
In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties. PloS one\| PubMed ID: 23383092	2013
Astrocytes protect neurons against methylmercury via ATP/P2Y(1) receptor-mediated pathways in astrocytes. PloS one\| PubMed ID: 23469098	2013
Microglia release ATP by exocytosis. Glia\| PubMed ID: 23832620	2013
Involvement of glial P2Y₁ receptors in cognitive deficit after focal cerebral stroke in a rodent model. Journal of neuroinflammation\| PubMed ID: 23890321	2013
Mechanism underlying ATP release in human epidermal keratinocytes. The Journal of investigative dermatology\| PubMed ID: 24292772	2014
Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission. Scientific reports\| PubMed ID: 24710318	2014
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures. The Journal of biological chemistry\| PubMed ID: 24759099	2014
Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy. Journal of neuropathology and experimental neurology\| PubMed ID: 25003238	2014
TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25681460	2015
Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms. European journal of pharmacology\| PubMed ID: 25701723	2015
Astrocyte-mediated ischemic tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25740510	2015
Müller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y receptor signals. Journal of neurochemistry\| PubMed ID: 26560804	2016
Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mechanisms of development\| PubMed ID: 26940020	2016
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. The Journal of clinical investigation\| PubMed ID: 27064281	2016
The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria. Neurourology and urodynamics\| PubMed ID: 27348079	2017
Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase. Scientific reports\| PubMed ID: 27412485	2016
An effective therapeutic approach for oxaliplatin-induced peripheral neuropathy using a combination therapy with goshajinkigan and bushi. Cancer biology & therapy\| PubMed ID: 27416484	2016
Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa. PloS one\| PubMed ID: 28060940	2017
Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning. Glia\| PubMed ID: 28063215	2017
Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction. Journal of cellular and molecular medicine\| PubMed ID: 28244642	2017
P2Y-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice. Scientific reports\| PubMed ID: 28396595	2017
Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay. The American journal of pathology\| PubMed ID: 28427592	2017
Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y Receptor Downregulation. Cell reports\| PubMed ID: 28494865	2017
Astrocyte-mediated synapse remodeling in the pathological brain. Glia\| PubMed ID: 28569048	2017
Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production. Journal of neurochemistry\| PubMed ID: 28628214	2017
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nature communications\| PubMed ID: 28642575	2017
Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation. Scientific reports\| PubMed ID: 28694451	2017
The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells. Neurourology and urodynamics\| PubMed ID: 28881406	2018
Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy. JCI insight\| PubMed ID: 28978804	2017
Author Correction: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nature communications\| PubMed ID: 29138397	2017
Astrocytes and ischemic tolerance. Neuroscience research\| PubMed ID: 29225139	2018
Astrocytes as therapeutic targets in brain diseases. Neuroscience research\| PubMed ID: 29289274	2018
Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca Dynamics in Astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 29305530	2018
New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia. Neurochemistry international\| PubMed ID: 29360494	2018
Aberrant astrocyte Ca signals "AxCa signals" exacerbate pathological alterations in an Alexander disease model. Glia\| PubMed ID: 29383757	2018
The oscillation of intracellular Ca influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium. Scientific reports\| PubMed ID: 29632308	2018
Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine\| PubMed ID: 29887330	2018
The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene. Neurourology and urodynamics\| PubMed ID: 30106187	2018
Neuroprotective effects of microglial P2Y receptors against ischemic neuronal injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 30334687	2019
Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium. PloS one\| PubMed ID: 30365528	2018
Microglia mediate non-cell-autonomous cell death of retinal ganglion cells. Glia\| PubMed ID: 30375063	2018
[Epileptogenesis mediated by glial cells]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica\| PubMed ID: 30531096	2018
Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders. International journal of molecular sciences\| PubMed ID: 30823575	2019
Hyaluronan synthesis supports glutamate transporter activity. Journal of neurochemistry\| PubMed ID: 31188471	2019
Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures. The Journal of toxicological sciences\| PubMed ID: 31270303	2019
Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration. Journal of neurochemistry\| PubMed ID: 31278875	2019
Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. Scientific reports\| PubMed ID: 31296902	2019
Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells. Scientific reports\| PubMed ID: 31685912	2019
Author Correction: Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. Scientific reports\| PubMed ID: 31700120	2019
[Pathogenic roles of retinal glia in glaucoma]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica\| PubMed ID: 32115484	2020
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32358018	2020
Reactive astrocyte nomenclature, definitions, and future directions. Nature neuroscience\| PubMed ID: 33589835	2021
Potential roles of astrocytes and Müller cells in the pathogenesis of glaucoma. Journal of pharmacological sciences\| PubMed ID: 33602506	2021
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus. JCI insight\| PubMed ID: 33830944	2021
Different effects of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice. Life sciences\| PubMed ID: 33930366	2021
Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance. Glia\| PubMed ID: 34076906	2021
Mechanical stretch-induced ATP release from keratinocytes triggers Koebner phenomenon in psoriasis. Journal of dermatological science\| PubMed ID: 34187740	2021
Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis. Science translational medicine\| PubMed ID: 34193610	2021
Loss of P2Y receptors triggers glaucoma-like pathology in mice. British journal of pharmacology\| PubMed ID: 34309010	2021
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice. Glia\| PubMed ID: 34309082	2021
Adenosine A receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development. Glia\| PubMed ID: 34339538	2021
Goshajinkigan attenuates paclitaxel-induced neuropathic pain via cortical astrocytes. Pharmacology research & perspectives\| PubMed ID: 34676996	2021
Glial pharmacology in Asia & Beyond. Pharmacology research & perspectives\| PubMed ID: 34676997	2021
Abnormal Ca Signals in Reactive Astrocytes as a Common Cause of Brain Diseases. International journal of molecular sciences\| PubMed ID: 35008573	2021
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina. Translational vision science & technology\| PubMed ID: 35040915	2022
Glial Purinergic Signals and Psychiatric Disorders. Frontiers in cellular neuroscience\| PubMed ID: 35069121	2021
Phagocytic astrocytes: Emerging from the shadows of microglia. Glia\| PubMed ID: 35142399	2022
Effects of fatty acid metabolites on nocturia. Scientific reports\| PubMed ID: 35197540	2022
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice. The Journal of experimental medicine\| PubMed ID: 35319723	2022
P2X7 Receptors in Astrocytes: A Switch for Ischemic Tolerance. Molecules (Basel, Switzerland)\| PubMed ID: 35744780	2022
Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour. Nature communications\| PubMed ID: 35835747	2022
Ischemic Tolerance Induced by Glial Cells. Neurochemical research\| PubMed ID: 35920970	2022