protocol-for-developing-a-femur-osteotomy-model-in-wistar-albino-rats

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Fracture healing is a physiological process resulting in the regeneration of bone defects by the coordinated action of osteoblasts and osteoclasts. ...

All India Institute of Medical Sciences (AIIMS)

Eosinophilic granuloma is the most common and benign form of a rare proliferative disorder: Langerhans' cell histiocytosis. Spinal involvement is rare and only 15 adult cases have been reported. We present an unusual variant of eosinophilic granuloma in a 25-year-old woman with radiological evidence of vertebra plana. Plain radiography, magnetic resonance imaging, bone scan, and blood tests were carried out, and a specimen was taken from L4 using computed tomography-guided biopsy. Gram staining, acid fast bacillus smear, bacterial and fungal cultures were negative. Histological examination of the biopsy showed features of eosinophilic granuloma with aggregates of Langerhans histiocytes. The patient was treated with low-grade radiotherapy at 150 cGy per day for 7 days. She was asymptomatic at one-year follow-up although the radiological picture was unchanged.

An unusual presentation of eosinophilic granuloma in an adult: a case report.

To assess the results of treatment for flexion-type supracondylar humeral fracture in children.

Treatment of flexion-type supracondylar humeral fracture in children.

Large femoral neck defects are frequently associated with neglected femoral neck fractures, sequelae of infection, and failed fixation devices. The AIIMS box technique of neck reconstruction has the objectives of femoral head preservation and restoration of hip function in such cases. 32 patients (age range 20-56, average 38 years) with large femoral neck defects were treated from January 1990 to May 1997 and were followed up for a minimum of 10 years (range 10 to 17 years). The neck defect was converted into a box using osteal flaps (base from greater trochanter, anterior wall from head, quadratus femoris muscle pedicle graft posteriorly), which was filled with cancellous bone autograft, and stabilized with cancellous screws. Union occurred in all patients in a mean time of 16 weeks (range 12-20 weeks). One patient developed avascular necrosis (AVN) of femoral head. 8 out of 32 results were classified as excellent, 22 good and 2 fair. Good functional mobility was seen in all but two patients. Complications included coxa vara in two patients, and fixation problems in four patients. Large femoral neck defects can be managed successfully by this technique with preservation of the viability of the femoral head, and therefore the procedure should be considered in appropriate cases, particularly in young adults.

Neck reconstruction (AIIMS Box Technique) in the management of large femoral neck defects.

Fracture of the femoral prosthesis neck following total hip arthroplasty is not common. We report a case of femoral prosthesis neck fracture in an adult male patient following modular, uncemented total hip arthroplasty. This case report further emphasizes the importance of the potentially high loading situation in the prosthetic femoral neck. On the other hand, the occurrence of a femoral prosthesis neck fracture in a cementless system denotes a well fixed distal stem and calls for a difficult revision procedure usually requiring an extended trochanteric osteotomy for stem retrieval.

Femoral prosthesis neck fracture following total hip arthroplasty: a case report.

Tumoral calcinosis is an autosomal recessive, metabolic disorder, characterised by deposition of calcium salts in the subcutaneous tissues of the body. We present a case of massive, recurrent tumoral calcinosis in a 32-year-old male patient.

Massive recurrent tumoral calcinosis: a rare presentation.

To review outcomes of 106 patients after complete excision of the giant cell tumour of the tendon sheath of the hand, with or without postoperative radiotherapy.

Giant cell tumour of the tendon sheath of the hand.

Sacroiliitis caused by Salmonella typhi is rare. In India, unilateral sacroiliitis is usually caused by tuberculosis. We report a 22-year-old man who presented with a high-grade fever and positive blood culture for Salmonella typhi. The patient was treated with intravenous vancomycin and levofloxacin for 15 days and then oral levofloxacin for 6 weeks.

Sacroiliitis caused by Salmonella typhi: a case report.

Glomus tumours are benign, vascular neoplasms arising from glomus body and are often found near the fingertips. Complete surgical excision of the tumour must be ensured to avoid its recurrence. Several surgical approaches for its excision have been described in the literature; however, most of the approaches are associated with nail deformity in the post-operative period or fail to offer a complete exposure of the tumour. We wish to share our experience with our described nail-preserving modified lateral subperiosteal approach, where on account of the distal curve over the pulp tip, we achieve a large flap yielding an excellent exposure of the tumour mass.

Nail-preserving modified lateral subperiosteal approach for subungual glomus tumour: a novel surgical approach.

Fracture union is a complex biological process, which depends upon several systemic and local factors. Disturbance of any of these factors may lead to nonunion of the fracture. These nonunions have a huge impact on quality of life as well as socioeconomical aspects. The platelets on activation release a number of growth factors and differentiation factors, which play important role in fracture healing. This study aimed to look for efficacy of platelet-rich plasma in the treatment of established fracture nonunions of long bones.

Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study.

Spinal deformities are very challenging to treat and have a great risk of neurologic complications because of hardware placement during corrective surgery. Various techniques have been introduced to ensure safe and accurate placement of pedicle screws. Patient-specific screw guides with predrawn and prevalidated trajectory seem to be an attractive option.

Outcome and safety analysis of 3D-printed patient-specific pedicle screw jigs for complex spinal deformities: a comparative study.

Osteoporosis and fragility fractures have become a major healthcare challenge globally in the recent years. However, this problem has only recently been accorded its due importance in developing countries such as India. India is a model case study for the management of osteoporosis and fragility fractures in a resource-limited setting, as it harbors a large geriatric population and has the highest prevalence of osteopenia globally. It is imperative to identify the myriad factors contributing to poor bone health and understand the many hurdles encountered to tackle this healthcare problem in a developing country. Innovative methods for managing fragility fractures are commonly seen. Collaborative multidisciplinary care and structured, evidence-based management has finally found its place in India with the establishment of a regional fragility fracture network. This chapter outlines the current status of management of fragility fractures in India by focusing on the disease burden, hurdles, innovative treatment methods, and the challenges lying ahead.

Management of fragility fractures in India.

Responsive immunity plays an important role fighting against infections. Worldwide, Vitamin D deficiency is a major concern not only for musculoskeletal health but also affecting the immunity status in population. Amidst COVID-19 pandemic, it is imperative to establish the role of vitamin D in destruction of pathogens. Vitamin D awareness program at school level might be an effective health governance policy to educate populations for the importance of vitamin D in overall health.

COVID-19 infection, inception and immunity: Observations and recommendations in the light of vitamin D?

To describe clinical, radiological and functional outcomes of patients with post-tubercular healed kyphosis operated by posterior-only three-column osteotomy.

Clinical, radiological and functional outcome of posterior-only three-column osteotomy in healed, post-tubercular kyphotic deformity: a minimum of 2-year follow-up.

To report the histopathological, electron microscopic, and immunohistochemical findings of tissue samples obtained from patients with radial longitudinal deficiency (RLD) and investigate the contribution of abnormality in soft tissues as a secondary driver of deformity in RLD.

Histopathological, Ultrastructural, and Immunohistochemical Findings in Radial Longitudinal Deficiency: A Prospective, Observational Study.

Accurate prediction of operative duration is necessary for efficient operating room scheduling, minimizing cancellations, shortening waitlists, better risk stratification, and effective preoperative counseling. Prolonged operative duration is also associated with negative patient outcomes. Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) is typically a lengthy surgical procedure with variable operative duration. The purpose of this study is to identify patient-, procedure-, and surgeon-specific variables that influence the operative duration in PSF for AIS and determine its impact on early postoperative outcomes.

Article	Year
An unusual presentation of eosinophilic granuloma in an adult: a case report. Journal of orthopaedic surgery (Hong Kong)\| PubMed ID: 16598094	2006
Treatment of flexion-type supracondylar humeral fracture in children. Journal of orthopaedic surgery (Hong Kong)\| PubMed ID: 17709856	2007
Neck reconstruction (AIIMS Box Technique) in the management of large femoral neck defects. Hip international : the journal of clinical and experimental research on hip pathology and therapy\| PubMed ID: 21279960	2011
Femoral prosthesis neck fracture following total hip arthroplasty: a case report. Acta orthopaedica Belgica\| PubMed ID: 21846014	2011
Massive recurrent tumoral calcinosis: a rare presentation. Acta orthopaedica Belgica\| PubMed ID: 21846015	2011
Giant cell tumour of the tendon sheath of the hand. Journal of orthopaedic surgery (Hong Kong)\| PubMed ID: 21857049	2011
Sacroiliitis caused by Salmonella typhi: a case report. Journal of orthopaedic surgery (Hong Kong)\| PubMed ID: 21857055	2011
Nail-preserving modified lateral subperiosteal approach for subungual glomus tumour: a novel surgical approach. Musculoskeletal surgery\| PubMed ID: 25957553	2016
Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study. Musculoskeletal surgery\| PubMed ID: 26193983	2015
Outcome and safety analysis of 3D-printed patient-specific pedicle screw jigs for complex spinal deformities: a comparative study. The spine journal : official journal of the North American Spine Society\| PubMed ID: 29730456	2019
Management of fragility fractures in India. Best practice & research. Clinical rheumatology\| PubMed ID: 31547985	2019
COVID-19 infection, inception and immunity: Observations and recommendations in the light of vitamin D? Journal of infection and public health\| PubMed ID: 33751982	2021
Clinical, radiological and functional outcome of posterior-only three-column osteotomy in healed, post-tubercular kyphotic deformity: a minimum of 2-year follow-up. Spine deformity\| PubMed ID: 33978945	2021
Histopathological, Ultrastructural, and Immunohistochemical Findings in Radial Longitudinal Deficiency: A Prospective, Observational Study. The Journal of hand surgery\| PubMed ID: 34452798	2022
Predictors of Operative Duration in Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: A Retrospective Cohort Study. International journal of spine surgery\| PubMed ID: 35772986	2022

Bhavuk Garg

Biography

JoVE Journal Publications

Other Publications