Robert J. Vassar

Department of Neurology, Northwestern University Feinberg School of Medicine

Affiliated withNorthwestern University Feinberg School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2022

Other Publications

Article	Year
The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19828790	2009
BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Molecular neurodegeneration\| PubMed ID: 20731874	2010
The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease. Alzheimer's research & therapy\| PubMed ID: 21639952	2011
Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis. Current Alzheimer research\| PubMed ID: 23919773	2013
ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD. Neuron\| PubMed ID: 24139026	2013
Targeting the β secretase BACE1 for Alzheimer's disease therapy. The Lancet. Neurology\| PubMed ID: 24556009	2014
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Molecular neurodegeneration\| PubMed ID: 24885175	2014
The normal and pathologic roles of the Alzheimer's β-secretase, BACE1. Current Alzheimer research\| PubMed ID: 24893886	2014
Molecular neurodegeneration: basic biology and disease pathways. Molecular neurodegeneration\| PubMed ID: 25248568	2014
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Molecular neurodegeneration\| PubMed ID: 25567526	2015
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta neuropathologica\| PubMed ID: 26993139	2016
Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease. Neuroscience and biobehavioral reviews\| PubMed ID: 27044452	2016
Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease. Neuron\| PubMed ID: 29216455	2017
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. Science translational medicine\| PubMed ID: 30232227	2018
ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease. The Journal of biological chemistry\| PubMed ID: 30315100	2018
A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease. EMBO molecular medicine\| PubMed ID: 30322841	2018
Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus. The journal of prevention of Alzheimer's disease\| PubMed ID: 30756113	2019
Death by microglia. The Journal of experimental medicine\| PubMed ID: 31645368	2019
Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice. Science translational medicine\| PubMed ID: 32998969	2020
Early detection and personalized medicine: Future strategies against Alzheimer's disease. Progress in molecular biology and translational science\| PubMed ID: 33453940	2021
A promising new γ-secretase modulator for Alzheimer's disease. The Journal of experimental medicine\| PubMed ID: 33683299	2021
The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nature reviews. Neurology\| PubMed ID: 34548654	2021