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JoVE Journal Neuroscience
Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
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Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain

Article DOI: 10.3791/63816-v • 09:00 min • April 28th, 2022
April 28th, 2022 •
1, 1, 1
1Department of Neurology, Northwestern University Feinberg School of Medicine

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Summary
Automatic Translation

This biochemical purification method with mass spectrometry-based proteomic analysis facilitates the robust characterization of amyloid fibril cores, which may accelerate the identification of targets for preventing Alzheimer's disease.

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Biochemical Purification Proteomic Characterization Amyloid Fibril Cores Alzheimer's Disease Amyloid Plaques Protein Content Therapeutic Intervention Disease Onset Protein Deposits Brain Tissues Protein Aggregates Homogenization Buffer Bead Mill Homogenizer Solubilization Sucrose
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