Neil Spratt

Biomedical Sciences and Pharmacy, The University of Newcastle

Affiliated withThe University of Newcastle University of Newcastle John Hunter Hospital, Hunter New England Local Health District

Research Area

Medicine

Biography

Neil Spratt has not added Biography.
If you are Neil Spratt and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 30	2012
Publication title Cited by 6	2021

Other Publications

Article	Year
Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse. Brain, behavior, and immunity\| PubMed ID: 25749481	2015
Seasonal variation in stroke in the Hunter Region, Australia: a 5-year hospital-based study, 1995-2000. Stroke; a journal of cerebral circulation\| PubMed ID: 12677016	2003
A prospective study of predictors of prolonged hospital stay and disability after stroke. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 14592613	2003
Imaging the ischemic penumbra with 18F-fluoromisonidazole in a rat model of ischemic stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 15017016	2004
Ischaemic tolerance and mitochondrial uncoupling--can we learn from the cell? Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 15703472	2005
Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats. Journal of neuroscience methods\| PubMed ID: 16513179	2006
Characterization of fluoromisonidazole binding in stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 16763190	2006
Improving access to acute stroke therapies: a controlled trial of organised pre-hospital and emergency care. The Medical journal of Australia\| PubMed ID: 18928434	2008
The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke. Brain : a journal of neurology\| PubMed ID: 19509116	2009
Characterisation of the timing of binding of the hypoxia tracer FMISO after stroke. Brain research\| PubMed ID: 19595680	2009
Inducing stroke in aged, hypertensive, diabetic rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20068574	2010
Cardiogenic shock complicating subarachnoid haemorrhage diagnosed as Tako Tsubo cardiomyopathy: a cautionary tale. Heart, lung & circulation\| PubMed ID: 20418161	2010
An enriched environment improves sensorimotor function post-ischemic stroke. Neurorehabilitation and neural repair\| PubMed ID: 20834046	2010
Trends in stroke attack rates and case fatality in the Hunter region, Australia 1996-2008. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 20861621	2010
'Salvaged' stroke ischaemic penumbra shows significant injury: studies with the hypoxia tracer FMISO. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 20877386	2011
The rural Prehospital Acute Stroke Triage (PAST) trial protocol: a controlled trial for rapid facilitated transport of rural acute stroke patients to a regional stroke centre. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 21050409	2010
Defining the extent of irreversible brain ischemia using perfusion computed tomography. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 21178348	2011
Acute stroke thrombolysis: time to dispense with the clock and move to tissue-based decision making? Expert review of cardiovascular therapy\| PubMed ID: 21517729	2011
Establishing a rodent stroke perfusion computed tomography model. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 21609409	2011
Perfusion computer tomography: imaging and clinical validation in acute ischaemic stroke. Brain : a journal of neurology\| PubMed ID: 22075524	2011
A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. The New England journal of medicine\| PubMed ID: 22435369	2012
Exploring the efficacy of constraint in animal models of stroke: meta-analysis and systematic review of the current evidence. Neurorehabilitation and neural repair\| PubMed ID: 22714123	2013
αCaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22929440	2012
Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 23149554	2013
Referral and triage of patients with transient ischemic attacks to an acute access clinic: risk stratification in an Australian setting. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 23490207	2013
An enriched environment increases activity in stroke patients undergoing rehabilitation in a mixed rehabilitation unit: a pilot non-randomized controlled trial. Disability and rehabilitation\| PubMed ID: 23627534	2014
Inadvertent occlusion of the anterior choroidal artery explains infarct variability in the middle cerebral artery thread occlusion stroke model. PloS one\| PubMed ID: 24069448	2013
Arterial spin labeling versus bolus-tracking perfusion in hyperacute stroke. Stroke\| PubMed ID: 24302482	2014
Exercise reduces infarct volume and facilitates neurobehavioral recovery: results from a systematic review and meta-analysis of exercise in experimental models of focal ischemia. Neurorehabilitation and neural repair\| PubMed ID: 24553105	2014
Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats. Fluids and barriers of the CNS\| PubMed ID: 24932405	2014
Allopregnanolone and its precursor progesterone do not reduce injury after experimental stroke in hypertensive rats - role of postoperative temperature regulation? PloS one\| PubMed ID: 25248155	2014
Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 25269516	2014
Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 25515213	2015
Platelet rich clots are resistant to lysis by thrombolytic therapy in a rat model of embolic stroke. Experimental & translational stroke medicine\| PubMed ID: 25657829	2015
Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion afte... Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 25669909	2015
Perfusion computed tomography to assist decision making for stroke thrombolysis. Brain : a journal of neurology\| PubMed ID: 25808369	2015
Feasibility of Recruiting Families into a Heart Disease Prevention Program Based on Dietary Patterns. Nutrients\| PubMed ID: 26308048	2015
Tissue Plasminogen Activator for preclinical stroke research: Neither "rat" nor "human" dose mimics clinical recanalization in a carotid occlusion model. Scientific reports\| PubMed ID: 26522691	2015
A comprehensive analysis of metabolic changes in the salvaged penumbra. Neuroradiology\| PubMed ID: 26738878	2016
Ischemic penumbra as a trigger for intracranial pressure rise - A potential cause for collateral failure and infarct progression? Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26759431	2016
Global White Matter Hypoperfusion on CT Predicts Larger Infarcts and Hemorrhagic Transformation after Acute Ischemia. CNS neuroscience & therapeutics\| PubMed ID: 26775830	2016
Intracranial Pressure and Collateral Blood Flow. Stroke\| PubMed ID: 26786117	2016
Thrombolytic Recanalization of Carotid Arteries Is Highly Dependent on Degree of Stenosis, Despite Sonothrombolysis. Journal of the American Heart Association\| PubMed ID: 26908405	2016
Sonothrombolysis with BR38 Microbubbles Improves Microvascular Patency in a Rat Model of Stroke. PloS one\| PubMed ID: 27077372	2016
A Home- and Community-Based Physical Activity Program Can Improve the Cardiorespiratory Fitness and Walking Capacity of Stroke Survivors. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 27378733	2016
Independently ambulant, community-dwelling stroke survivors have reduced cardiorespiratory fitness, mobility and knee strength compared to an age- and gender-matched cohort. Topics in stroke rehabilitation\| PubMed ID: 27670905	2017
The Role of Family in a Dietary Risk Reduction Intervention for Cardiovascular Disease. Healthcare (Basel, Switzerland)\| PubMed ID: 27706027	2016
Effectiveness of a Brief Dietetic Intervention for Hyperlipidaemic Adults Using Individually-Tailored Dietary Feedback. Healthcare (Basel, Switzerland)\| PubMed ID: 27727165	2016
Breaking up sitting time after stroke (BUST-Stroke). International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 27794137	2017
The establishment of a telestroke service using multimodal CT imaging decision assistance: "Turning on the fog lights". Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 27887976	2017
Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative neurology and neuroscience\| PubMed ID: 28059802	2017
Ischaemia- and excitotoxicity-induced CaMKII-Mediated neuronal cell death: The relative roles of CaMKII autophosphorylation at T286 and T253. Neurochemistry international\| PubMed ID: 28065796	2017
Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke. Stroke\| PubMed ID: 28104836	2017
The role of Ca-calmodulin stimulated protein kinase II in ischaemic stroke - A potential target for neuroprotective therapies. Neurochemistry international\| PubMed ID: 28153786	2017
Validation of the National Institutes of Health Stroke Scale-8 to Detect Large Vessel Occlusion in Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 28457621	2017
Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials. Neurology\| PubMed ID: 28576782	2017
Boredom in patients with acquired brain injuries during inpatient rehabilitation: a scoping review. Disability and rehabilitation\| PubMed ID: 28760011	2018
Cardiorespiratory fitness and walking endurance improvements after 12 months of an individualised home and community-based exercise programme for people after stroke. Brain injury\| PubMed ID: 28872360	2017
The influence of initial stroke severity on mortality, overall functional outcome and in-hospital placement at 90 days following acute ischemic stroke: A tertiary hospital stroke register st... Neurology India\| PubMed ID: 29133696	2017
Thresholds for infarction vary between gray matter and white matter in acute ischemic stroke: A CT perfusion study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 29172990	2019
The unmet needs of informal carers of stroke survivors: a protocol for a systematic review of quantitative and qualitative studies. BMJ open\| PubMed ID: 29391371	2018
Tissue Is More Important than Time in Stroke Patients Being Assessed for Thrombolysis. Frontiers in neurology\| PubMed ID: 29467716	2018
Correction for Delay and Dispersion Results in More Accurate Cerebral Blood Flow Ischemic Core Measurement in Acute Stroke. Stroke\| PubMed ID: 29500248	2018
Evaluation of three measures of cardiorespiratory fitness in independently ambulant stroke survivors. Physiotherapy theory and practice\| PubMed ID: 29601228	2019
Intravenous Thrombolysis May Not Improve Clinical Outcome of Acute Ischemic Stroke Patients Without a Baseline Vessel Occlusion. Frontiers in neurology\| PubMed ID: 29928251	2018
Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats. Neuroscience letters\| PubMed ID: 30076987	2018
White Matter Degeneration after Ischemic Stroke: A Longitudinal Diffusion Tensor Imaging Study. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 30160814	2019
Frequent, short bouts of light-intensity exercises while standing decreases systolic blood pressure: Breaking Up Sitting Time after Stroke (BUST-Stroke) trial. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 30223728	2018
Breaking up sitting time after stroke (BUST-stroke). International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 30226448	2018
Growth Hormone Deficiency Is Frequent After Recent Stroke. Frontiers in neurology\| PubMed ID: 30237782	2018
Do powered over-ground lower limb robotic exoskeletons affect outcomes in the rehabilitation of people with acquired brain injury? Disability and rehabilitation. Assistive technology\| PubMed ID: 30241453	2019
Single-phase CT angiography: collateral grade is independent of scan weighting. Neuroradiology\| PubMed ID: 30288551	2019
The International comparison of Systems of care and patient outcomes In minor Stroke and Tia (InSIST) study: A community-based cohort study. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 30608031	2019
Breaking up sitting time after stroke - How much less sitting is needed to improve blood pressure after stroke (BUST-BP-Dose): Protocol for a dose-finding study. Contemporary clinical trials communications\| PubMed ID: 30740549	2019
Predicting Modafinil-Treatment Response in Poststroke Fatigue Using Brain Morphometry and Functional Connectivity. Stroke\| PubMed ID: 30777001	2019
Cognitive dysfunction is associated with abnormal responses in cerebral blood flow in patients with single ventricular physiology: Novel insights from transcranial Doppler ultrasound. Congenital heart disease\| PubMed ID: 30908884	2019
Influence of occlusion site and baseline ischemic core on outcome in patients with ischemic stroke. Neurology\| PubMed ID: 31043475	2019
"This is our life now. Our new normal": A qualitative study of the unmet needs of carers of stroke survivors. PloS one\| PubMed ID: 31067286	2019
Choroid plexus volume after stroke. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 31096870	2019
Contemporary trends in stroke complicating cardiac catheterisation. Internal medicine journal\| PubMed ID: 31211489	2020
The unmet needs of carers of stroke survivors: An evaluation of Google search results. Health informatics journal\| PubMed ID: 31213117	2020
Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue. Scientific reports\| PubMed ID: 31273283	2019
An online intervention for improving stroke survivors' health-related quality of life: study protocol for a randomised controlled trial. Trials\| PubMed ID: 31399140	2019
An online cross-sectional survey of the health risk behaviours among informal caregivers. Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals\| PubMed ID: 31529552	2020
YouTube as a resource for evaluating the unmet needs of caregivers of stroke survivors. Health informatics journal\| PubMed ID: 31722610	2020
Computed Tomography Perfusion Identifies Patients With Stroke With Impaired Cardiac Function. Stroke\| PubMed ID: 31896345	2020
Perfusion Computed Tomography Accurately Quantifies Collateral Flow After Acute Ischemic Stroke. Stroke\| PubMed ID: 31948385	2020
No Evidence of the "Weekend Effect" in the Northern New South Wales Telestroke Network. Frontiers in neurology\| PubMed ID: 32174885	2020
The long-term unmet needs of informal carers of stroke survivors at home: a systematic review of qualitative and quantitative studies. Disability and rehabilitation\| PubMed ID: 32393074	2020
Permeability Measures Predict Hemorrhagic Transformation after Ischemic Stroke. Annals of neurology\| PubMed ID: 32418242	2020
The Characteristics of Patients With Possible Transient Ischemic Attack and Minor Stroke in the Hunter and Manning Valley Regions, Australia (the INSIST Study). Frontiers in neurology\| PubMed ID: 32670173	2020
Air vs. Road Decision for Endovascular Clot Retrieval in a Rural Telestroke Network. Frontiers in neurology\| PubMed ID: 32765396	2020
Exploring the Economic Benefits of Modafinil for Post-Stroke Fatigue in Australia: A Cost-Effectiveness Evaluation. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 33066879	2020
Tranexamic acid in patients with intracerebral haemorrhage (STOP-AUST): a multicentre, randomised, placebo-controlled, phase 2 trial. The Lancet. Neurology\| PubMed ID: 33128912	2020
Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples. Frontiers in neurology\| PubMed ID: 33224099	2020
Association of Collateral Status and Ischemic Core Growth in Patients With Acute Ischemic Stroke. Neurology\| PubMed ID: 33262233	2021
An online survey of informal caregivers' unmet needs and associated factors. PloS one\| PubMed ID: 33301483	2020
Multimodal Computed Tomography Increases the Detection of Posterior Fossa Strokes Compared to Brain Non-contrast Computed Tomography. Frontiers in neurology\| PubMed ID: 33329332	2020
Reduced Impact of Endovascular Thrombectomy on Disability in Real-World Practice, Relative to Randomized Controlled Trial Evidence in Australia. Frontiers in neurology\| PubMed ID: 33363508	2020
Role of Computed Tomography Perfusion in Identification of Acute Lacunar Stroke Syndromes. Stroke\| PubMed ID: 33370180	2021
What Is the "Optimal" Target Mismatch Criteria for Acute Ischemic Stroke? Frontiers in neurology\| PubMed ID: 33584495	2020