Betty Tyler

Department of Neurosurgery, Johns Hopkins University School of Medicine

Affiliated withJohns Hopkins University School of Medicine

Research Area

Cancer ResearchBioengineeringNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 1	2022
Publication title Cited by 7	2023
Publication title Cited by 1	2024
Publication title Cited by 4	2023

Other Publications

Article	Year
The intracerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats. Epilepsy research\| PubMed ID: 11904233	2002
Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy. Journal of neuro-oncology\| PubMed ID: 12061726	2002
Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor. Journal of neurosurgical anesthesiology\| PubMed ID: 12172290	2002
Prevention of experimental cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled-release polymer: toxicity and efficacy studies in rabbits and rats. Stroke; a journal of cerebral circulation\| PubMed ID: 12411661	2002
Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12960135	2003
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma. Journal of neuro-oncology\| PubMed ID: 14558595	2003
Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo. Neurosurgery\| PubMed ID: 15113479	2004
Section on tumors: Young Investigator Award: Local release of carboplatin via an Alzet mini-osmotic pump prolongs survival in a rat brainstem tumor model. Clinical neurosurgery\| PubMed ID: 15571163	2004
A novel rat model for the study of intraosseous metastatic spine cancer. Journal of neurosurgery. Spine\| PubMed ID: 15796355	2005
Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma. Journal of neuro-oncology\| PubMed ID: 16193383	2005
Local delivery of doxorubicin for the treatment of malignant brain tumors in rats. Anticancer research\| PubMed ID: 16312042	2005
A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization. Journal of neurosurgery. Spine\| PubMed ID: 16370303	2005
Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis. Cancer research\| PubMed ID: 17804705	2007
Coexpression of neuronatin splice forms promotes medulloblastoma growth. Neuro-oncology\| PubMed ID: 18701710	2008
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Molecular cancer therapeutics\| PubMed ID: 19208828	2009
Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. Journal of neuro-oncology\| PubMed ID: 19693439	2010
A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats. Journal of neurosurgery\| PubMed ID: 20001591	2010
Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model. Neurosurgery\| PubMed ID: 20173548	2010
FasL gene knock-down therapy enhances the antiglioma immune response. Neuro-oncology\| PubMed ID: 20406899	2010
Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas. Neuro-oncology\| PubMed ID: 20511190	2010
Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature medicine\| PubMed ID: 21170048	2011
Local delivery of rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats. Neuro-oncology\| PubMed ID: 21727209	2011
Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel. Journal of neurosurgery. Spine\| PubMed ID: 22208429	2012
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. Biomaterials\| PubMed ID: 22591609	2012
The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas. Cancer chemotherapy and pharmacology\| PubMed ID: 22644796	2012
Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22966020	2012
Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging. Journal of neuro-oncology\| PubMed ID: 23011120	2012
Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model. Journal of neuro-oncology\| PubMed ID: 23224713	2013
Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model. Cancer chemotherapy and pharmacology\| PubMed ID: 23649683	2013
Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma. Journal of neurosurgery\| PubMed ID: 23909244	2013
Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models. Journal of neuro-oncology\| PubMed ID: 24185441	2014
Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models. Journal of neurosurgery\| PubMed ID: 24484234	2014
Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres. Journal of neurosurgery\| PubMed ID: 24605841	2014
Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy. Stroke\| PubMed ID: 24627118	2014
Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. PloS one\| PubMed ID: 25013914	2014
Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma. Neuro-oncology\| PubMed ID: 25053853	2015
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo. ACS nano\| PubMed ID: 25643235	2015
Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy. Surgical neurology international\| PubMed ID: 25722936	2015
Miniaturized optical neuroimaging in unrestrained animals. NeuroImage\| PubMed ID: 25791782	2015
Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers. Biomaterials\| PubMed ID: 25818456	2015
Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats. Oncotarget\| PubMed ID: 25849940	2015
MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 26249244	2015
Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. Journal of ophthalmology\| PubMed ID: 26491546	2015
The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory. Academic medicine : journal of the Association of American Medical Colleges\| PubMed ID: 26934692	2016
Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 27016141	2016
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. Journal for immunotherapy of cancer\| PubMed ID: 27190629	2016
Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival. Biomaterials\| PubMed ID: 27240162	2016
Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications. Carbohydrate polymers\| PubMed ID: 27312642	2016
Polylactic acid (PLA) controlled delivery carriers for biomedical applications. Advanced drug delivery reviews\| PubMed ID: 27426411	2016
Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. Journal for immunotherapy of cancer\| PubMed ID: 27822377	2016
Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM. Science translational medicine\| PubMed ID: 28003545	2016
Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28279797	2017
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model. Journal of neurosurgery. Spine\| PubMed ID: 28598292	2017
The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma. Journal of neuro-oncology\| PubMed ID: 28735458	2017
HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy. Scientific reports\| PubMed ID: 29097800	2017
Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma. Oncotarget\| PubMed ID: 29755681	2018
Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer. Journal of neurosurgery\| PubMed ID: 30074457	2018
Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 30605703	2019
A miniature multi-contrast microscope for functional imaging in freely behaving animals. Nature communications\| PubMed ID: 30626878	2019
Evaluation of select biocompatible markers for labelling peripheral nerves on 11.7 T MRI. Journal of neuroscience methods\| PubMed ID: 30630001	2019
The Use of Ribavirin as an Anticancer Therapeutic: Will It Go Viral? Molecular cancer therapeutics\| PubMed ID: 31263027	2019
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 31655205	2020
Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor. Scientific reports\| PubMed ID: 31784666	2019
Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies. Scientific reports\| PubMed ID: 32376983	2020
Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration. Bioengineering & translational medicine\| PubMed ID: 32440565	2020
Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model. Neurosurgery\| PubMed ID: 32521017	2020
Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma. Molecular cancer therapeutics\| PubMed ID: 32606016	2020
Captopril inhibits Matrix Metalloproteinase-2 and extends survival as a temozolomide adjuvant in an intracranial gliosarcoma model. Clinical neurology and neurosurgery\| PubMed ID: 34198223	2021
High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications. Annals of biomedical engineering\| PubMed ID: 34374945	2021
Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma. Journal of neurosurgery\| PubMed ID: 34388730	2022
Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model. PloS one\| PubMed ID: 34731160	2021
Combined intracranial Acriflavine, temozolomide and radiation extends survival in a rat glioma model. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 34968646	2022
Automatic detection of cotton balls during brain surgery: Where deep learning meets ultrasound imaging to tackle foreign objects. Proceedings of SPIE--the International Society for Optical Engineering\| PubMed ID: 35233128	2021
Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma. Cancers\| PubMed ID: 35267591	2022
Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology. International journal of molecular sciences\| PubMed ID: 35456971	2022
Metformin and Cancer, an Ambiguanidous Relationship. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 35631452	2022
Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches. Polymers\| PubMed ID: 35890738	2022
Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy. Cancers\| PubMed ID: 35954407	2022
Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier. Cancers\| PubMed ID: 36230843	2022
A Highly Translatable Dual-arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor-bearing Brain Tissues. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 36651002	2023
Dendrimer Technology in Glioma: Functional Design and Potential Applications. Cancers\| PubMed ID: 36831418	2023
Towards standardization of the parameters for opening the blood-brain barrier with focused ultrasound to treat glioblastoma multiforme: A systematic review of the devices, animal models, and... Frontiers in oncology\| PubMed ID: 36873300	2022
Impact of international research fellows in neurosurgery: results from a single academic center. Journal of neurosurgery\| PubMed ID: 34298505	2022
The Neurodevelopmental and Molecular Landscape of Medulloblastoma Subgroups: Current Targets and the Potential for Combined Therapies. Cancers\| PubMed ID: 37568705	2023
Preclinical Models and Technologies in Glioblastoma Research: Evolution, Current State, and Future Avenues. International journal of molecular sciences\| PubMed ID: 38003507	2023
Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke. Brain, behavior, and immunity\| PubMed ID: 38070624	2024
GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. Experimental hematology & oncology\| PubMed ID: 38291540	2024
Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion. International journal of molecular sciences\| PubMed ID: 38473812	2024
CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy. Oncoimmunology\| PubMed ID: 38590799	2024