Joseph P. Noel

Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies

Affiliated withThe Salk Institute for Biological Studies University of California San Diego

Research Area

Biography

Joseph P. Noel has not added Biography.
If you are Joseph P. Noel and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2022

Other Publications

Article	Year
Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. The Journal of biological chemistry\| PubMed ID: 11698411	2002
Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. The Journal of biological chemistry\| PubMed ID: 11786530	2002
Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family. The Plant cell\| PubMed ID: 11884690	2002
Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry\| PubMed ID: 11955065	2002
Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11959984	2002
Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. The Plant cell\| PubMed ID: 12084826	2002
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Molecular cell\| PubMed ID: 12535537	2003
The chalcone synthase superfamily of type III polyketide synthases. Natural product reports\| PubMed ID: 12636085	2003
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular cell\| PubMed ID: 12718892	2003
The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry\| PubMed ID: 12834342	2003
Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. The Plant cell\| PubMed ID: 12897246	2003
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. The Journal of biological chemistry\| PubMed ID: 15265863	2004
Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens. Plant physiology\| PubMed ID: 15310828	2004
Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Biochemistry\| PubMed ID: 15379557	2004
An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Chemistry & biology\| PubMed ID: 15380179	2004
Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. The Journal of biological chemistry\| PubMed ID: 15522862	2005
A single-vial analytical and quantitative gas chromatography-mass spectrometry assay for terpene synthases. Analytical biochemistry\| PubMed ID: 15556559	2004
Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. Plant physiology\| PubMed ID: 15734921	2005
Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase. The Plant cell\| PubMed ID: 15829607	2005
Structure-function relationships in plant phenylpropanoid biosynthesis. Current opinion in plant biology\| PubMed ID: 15860421	2005
Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. PLoS biology\| PubMed ID: 15884974	2005
Floral benzenoid carboxyl methyltransferases: from in vitro to in planta function. Phytochemistry\| PubMed ID: 15946712	2005
Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Nature\| PubMed ID: 15959519	2005
Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. The Journal of biological chemistry\| PubMed ID: 15970585	2005
An Arabidopsis thaliana methyltransferase capable of methylating farnesoic acid. Archives of biochemistry and biophysics\| PubMed ID: 16165084	2006
Stereochemistry and deuterium isotope effects associated with the cyclization-rearrangements catalyzed by tobacco epiaristolochene and hyoscyamus premnaspirodiene synthases, and the chimeric... Archives of biochemistry and biophysics\| PubMed ID: 16309622	2006
Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase. Archives of biochemistry and biophysics\| PubMed ID: 16375847	2006
Biosynthesis of plant volatiles: nature's diversity and ingenuity. Science (New York, N.Y.)\| PubMed ID: 16469917	2006
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Biochemistry\| PubMed ID: 16533036	2006
Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases. The Plant journal : for cell and molecular biology\| PubMed ID: 16623883	2006
Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16782809	2006
Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16785438	2006
Structure-function-folding relationship in a WW domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16807295	2006
Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16864776	2006
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nature chemical biology\| PubMed ID: 16906151	2006
Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula. Plant molecular biology\| PubMed ID: 17001495	2006
Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnology and bioengineering\| PubMed ID: 17013941	2007
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. Journal of the American Chemical Society\| PubMed ID: 17105255	2006
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Molecular cell\| PubMed ID: 17157258	2006
Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. The Plant cell\| PubMed ID: 17172354	2006
Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17172845	2006
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chemistry & biology\| PubMed ID: 17185228	2006
Methylation of gibberellins by Arabidopsis GAMT1 and GAMT2. The Plant cell\| PubMed ID: 17220201	2007
Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry\| PubMed ID: 17240984	2007
Structural basis for high-affinity peptide inhibition of human Pin1. ACS chemical biology\| PubMed ID: 17518432	2007
A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. FEBS letters\| PubMed ID: 17543953	2007
Genetically encoding unnatural amino acids for cellular and neuronal studies. Nature neuroscience\| PubMed ID: 17603477	2007
Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. The Journal of biological chemistry\| PubMed ID: 17715131	2007
Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. Chembiochem : a European journal of chemical biology\| PubMed ID: 17886322	2007
Structure and reaction mechanism of basil eugenol synthase. PloS one\| PubMed ID: 17912370	2007
Digging for answers, smelling a hint of success and tasting triumph. Nature chemical biology\| PubMed ID: 17948014	2007
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nature chemical biology\| PubMed ID: 18059261	2008
Structural, biochemical, and phylogenetic analyses suggest that indole-3-acetic acid methyltransferase is an evolutionarily ancient member of the SABATH family. Plant physiology\| PubMed ID: 18162595	2008
The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. The Plant journal : for cell and molecular biology\| PubMed ID: 18208524	2008
Evolving biosynthetic tangos negotiate mechanistic landscapes. Nature chemical biology\| PubMed ID: 18347585	2008
Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. ACS chemical biology\| PubMed ID: 18376812	2008
Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants. Cell\| PubMed ID: 18394996	2008
Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. Bioorganic & medicinal chemistry\| PubMed ID: 18682327	2008
S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem : a European journal of chemical biology\| PubMed ID: 18720493	2008
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nature chemical biology\| PubMed ID: 18776889	2008
Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain. Plant physiology\| PubMed ID: 18987218	2009
The lack of floral synthesis and emission of isoeugenol in Petunia axillaris subsp. parodii is due to a mutation in the isoeugenol synthase gene. The Plant journal : for cell and molecular biology\| PubMed ID: 19222805	2009
Multiple biochemical and morphological factors underlie the production of methylketones in tomato trichomes. Plant physiology\| PubMed ID: 19801397	2009
Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. ACS chemical biology\| PubMed ID: 20175559	2010
Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. ACS chemical biology\| PubMed ID: 20392112	2010
Enzymatic functions of wild tomato methylketone synthases 1 and 2. Plant physiology\| PubMed ID: 20605911	2010
Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne). The Plant cell\| PubMed ID: 20952635	2010
Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference. The Plant cell\| PubMed ID: 21177481	2010
Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. ACS chemical biology\| PubMed ID: 21545173	2011
Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature\| PubMed ID: 21666665	2011
Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem cells (Dayton, Ohio)\| PubMed ID: 21681861	2011
Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato. The Plant cell\| PubMed ID: 22523203	2012
Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature\| PubMed ID: 22622584	2012
The rise of chemodiversity in plants. Science (New York, N.Y.)\| PubMed ID: 22745420	2012
Architectures, mechanisms and molecular evolution of natural product methyltransferases. Natural product reports\| PubMed ID: 22850796	2012
Structure-function analyses of plant type III polyketide synthases. Methods in enzymology\| PubMed ID: 22999180	2012
Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase. Virology journal\| PubMed ID: 23231773	2012
Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. Nature chemical biology\| PubMed ID: 23377040	2013
Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future. Current opinion in plant biology\| PubMed ID: 23481348	2013
Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23613584	2013
Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants. Frontiers in plant science\| PubMed ID: 23717312	2013
Expanding the library and substrate diversity of the pyrrolysyl-tRNA synthetase to incorporate unnatural amino acids containing conjugated rings. Chembiochem : a European journal of chemical biology\| PubMed ID: 24019075	2013
Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature\| PubMed ID: 24162851	2013
Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS chemical biology\| PubMed ID: 24168704	2014
The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Natural product reports\| PubMed ID: 24292120	2014
Discovery of a metabolic alternative to the classical mevalonate pathway. eLife\| PubMed ID: 24327557	2013
Genetically encoding photoswitchable click amino acids in Escherichia coli and mammalian cells. Angewandte Chemie (International ed. in English)\| PubMed ID: 24615769	2014
Spectral and structural comparison between bright and dim green fluorescent proteins in Amphioxus. Scientific reports\| PubMed ID: 24968921	2014
Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis. The Plant cell\| PubMed ID: 25217505	2014
Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26216978	2015
Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases. ACS chemical biology\| PubMed ID: 26378620	2015
Cryptochrome 1 interacts with PIF4 to regulate high temperature-mediated hypocotyl elongation in response to blue light. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26699514	2016
Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Current opinion in chemical biology\| PubMed ID: 26851514	2016
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27001835	2016
Local auxin metabolism regulates environment-induced hypocotyl elongation. Nature plants\| PubMed ID: 27249562	2016
Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants. The Journal of antibiotics\| PubMed ID: 27328867	2016
Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity. Cell\| PubMed ID: 27518563	2016
Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom. Current opinion in structural biology\| PubMed ID: 27662376	2016
Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry\| PubMed ID: 27805809	2016
Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246]. Current opinion in structural biology\| PubMed ID: 27884574	2016
Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28320959	2017
A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-Scale NMR-Coupled Crystalline Sponge X-ray Diffraction Analysis. Journal of the American Chemical Society\| PubMed ID: 29083151	2017
Molecular architectures of benzoic acid-specific type III polyketide synthases. Acta crystallographica. Section D, Structural biology\| PubMed ID: 29199980	2017
A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae. Biotechnology and bioengineering\| PubMed ID: 29457628	2018
Evolution of chalcone isomerase from a noncatalytic ancestor. Nature chemical biology\| PubMed ID: 29686356	2018
Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor. Nature chemical biology\| PubMed ID: 29760514	2018
Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nature plants\| PubMed ID: 30127411	2018
Strigolactone perception and deactivation by a hydrolase receptor DWARF14. Nature communications\| PubMed ID: 30643123	2019
Dissecting modular synthases through inhibition: A complementary chemical and genetic approach. Bioorganic & medicinal chemistry letters\| PubMed ID: 31812466	2020
Gating mechanism of elongating β-ketoacyl-ACP synthases. Nature communications\| PubMed ID: 32265440	2020
Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway. Nature chemical biology\| PubMed ID: 32284603	2020
Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an -prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32457155	2020
Activity Mapping the Acyl Carrier Protein: Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis. Biochemistry\| PubMed ID: 32857494	2020
Interfacial plasticity facilitates high reaction rate of FAS malonyl-CoA:ACP transacylase, FabD. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32929027	2020
Plant-based CO drawdown and storage as SiC. RSC advances\| PubMed ID: 35481209	2021