Dmitry Lyumkis

Laboratory of Genetics, The Salk Institute for Biological Studies

Affiliated withThe Salk Institute for Biological Studies University of California San Diego The Scripps Research Institute

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2022

Other Publications

Article	Year
Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy. Structure (London, England : 1993)\| PubMed ID: 26388028	2015
Single-particle cryoEM analysis at near-atomic resolution from several thousand asymmetric subunits. Journal of structural biology\| PubMed ID: 26470814	2015
Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature\| PubMed ID: 26887496	2016
Structural Basis for the Activation of IKK1/α. Cell reports\| PubMed ID: 27851956	2016
Modular Assembly of the Bacterial Large Ribosomal Subunit. Cell\| PubMed ID: 27912064	2016
Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome. Science (New York, N.Y.)\| PubMed ID: 28059769	2017
Addressing preferred specimen orientation in single-particle cryo-EM through tilting. Nature methods\| PubMed ID: 28671674	2017
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature\| PubMed ID: 28700571	2017
Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant. Nature communications\| PubMed ID: 30194371	2018
Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d. Cell\| PubMed ID: 30241607	2018
Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification. Ultramicroscopy\| PubMed ID: 30528101	2019
Challenges and opportunities in cryo-EM single-particle analysis. The Journal of biological chemistry\| PubMed ID: 30804214	2019
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. eLife\| PubMed ID: 31120420	2019
Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. Cell\| PubMed ID: 31348888	2019
Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease. Structure (London, England : 1993)\| PubMed ID: 31447289	2019
Non-uniformity of projection distributions attenuates resolution in Cryo-EM. Progress in biophysics and molecular biology\| PubMed ID: 31525386	2020
SrmB Rescues Trapped Ribosome Assembly Intermediates. Journal of molecular biology\| PubMed ID: 31877323	2020
Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science (New York, N.Y.)\| PubMed ID: 32001521	2020
HIV-1 Integrase Inhibitors That Are Active against Drug-Resistant Integrase Mutants. Antimicrobial agents and chemotherapy\| PubMed ID: 32601157	2020
Structural Biology of HIV Integrase Strand Transfer Inhibitors. Trends in pharmacological sciences\| PubMed ID: 32624197	2020
Tools for visualizing and analyzing Fourier space sampling in Cryo-EM. Progress in biophysics and molecular biology\| PubMed ID: 32645314	2021
Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd. Nature communications\| PubMed ID: 32719356	2020
Evaluating Local and Directional Resolution of Cryo-EM Density Maps. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33368004	2021
Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs. Viruses\| PubMed ID: 33572956	2021
HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants. ACS infectious diseases\| PubMed ID: 33686850	2021
Retroviral integrase: Structure, mechanism, and inhibition. The Enzymes\| PubMed ID: 34861940	2021
Quantitative mining of compositional heterogeneity in cryo-EM datasets of ribosome assembly intermediates. Structure (London, England : 1993)\| PubMed ID: 34990602	2022
Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity. The Journal of biological chemistry\| PubMed ID: 35202658	2022
Multivalent interactions essential for lentiviral integrase function. Nature communications\| PubMed ID: 35504909	2022