in-vitro-digestion-emulsions-single-droplet-via-multi-subphase

<em>In vitro</em> Digestion of Emulsions in a Single Droplet <em>via</em> Multi Subphase Exchange of Simulated Gastrointestinal Fluids

Emulsions are currently being used to encapsulate and deliver nutrients and drugs to tackle different gastrointestinal conditions such as obesity, ...

University of Granada

The Internet of Things (IoT) enables the communication among smart objects promoting the pervasive presence around us of a variety of things or objects that are able to interact and cooperate jointly to reach common goals. IoT objects can obtain data from their context, such as the home, office, industry or body. These data can be combined to obtain new and more complex information applying data fusion processes. However, to apply data fusion algorithms in IoT environments, the full system must deal with distributed nodes, decentralized communication and support scalability and nodes dynamicity, among others restrictions. In this paper, a novel method to manage data acquisition and fusion based on a distributed service composition model is presented, improving the data treatment in IoT pervasive environments. 

Distributed service-based approach for sensor data fusion in IoT environments.

The production of tomatoes in greenhouses, in addition to its relevance in nutrition and health, is an activity of the agroindustry with high economic importance in Spain, the first exporter in Europe of this vegetable. The technological updating with precision agriculture, implemented in order to ensure adequate production, leads to a deployment planning of wireless sensors with limited coverage by the attenuation of radio waves in the presence of vegetation. The well-known propagation models FSPL (Free-Space Path Loss), two-ray, COST235, Weissberger, ITU-R (International Telecommunications Union-Radiocommunication Sector), FITU-R (Fitted ITU-R), offer values with an error percentage higher than 30% in the 2.4 GHz band in relation to those measured in field tests. As a substantial improvement, we have developed optimized propagation models, with an error estimate of less than 9% in the worst-case scenario for the later benefit of farmers, consumers and the economic chain in the production of tomatoes.

Path Loss Determination Using Linear and Cubic Regression Inside a Classic Tomato Greenhouse.

The use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics. One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the addition of bioactive compounds to improve the delivery system being a current subject of study. This work shows the influence of two bioactive additives on the structure and stability of POL foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced the size and polydispersity of the bubble size distribution and increased the surface elasticity with respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble structure and increased surface elasticity, again contributing to the enhancement of foam stability. The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the target vein.

Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy.

Spain is Europe's leading exporter of tomatoes harvested in greenhouses. The production of tomatoes should be kept and increased, supported by precision agriculture to meet food and commercial demand. The wireless sensor network (WSN) has demonstrated to be a tool to provide farmers with useful information on the state of their plantations due to its practical deployment. However, in order to measure its deployment within a crop, it is necessary to know the communication coverage of the nodes that make up the network. The multipath propagation of radio waves between the transceivers of the WSN nodes inside a greenhouse is degraded and attenuated by the intricate complex of stems, branches, leaf twigs, and fruits, all randomly oriented, that block the line of sight, consequently generating a signal power loss as the distance increases. Although the COST235 (European Cooperation in Science and Technology - COST), ITU-R (International Telecommunications Union-Radiocommunication Sector), FITU-R (Fitted ITU-R), and Weisbberger models provide an explanation of the radio wave propagation in the presence of vegetation in the 2.4 GHz ICM band, some significant discrepancies were found when they are applied to field tests with tomato greenhouses. In this paper, a novel method is proposed for determining an empirical model of radio wave attenuation for vegetation in the 2.4 GHz band, which includes the vegetation height as a parameter in addition to the distance between transceivers of WNS nodes. The empirical attenuation model was obtained applying regularized regressions with a multiparametric equation using experimental signal RSSI measurements achieved by our own RSSI measurement system for our field tests in four plantations. The evaluation parameters gave 0.948 for R2, 0.946 for R2 Adj considering 5th grade polynomial (20 parameters), and 0.942 for R2, and 0.940 for R2 Adj when a reduction of parameters was applied using the cross validation (15 parameters). These results verify the rationality and reliability of the empirical model. Finally, the model was validated considering experimental data from other plantations, reaching similar results to our proposed model.

Empirical Model of Radio Wave Propagation in the Presence of Vegetation inside Greenhouses Using Regularized Regressions.

One of the major applications of Serum Albumins is their use as delivery systems for lipophilic compounds in biomedicine. Their biomedical application is based on the similarity with Human Serum Albumin (HSA), as a fully biocompatible protein. In general, Bovine Serum Albumin (BSA) is treated as comparable to its human homologue and used as a model protein for fundamental studies since it is available in high amounts and well understood. This protein can act as a carrier for lipophilic compounds or as protective shell in an emulsion-based vehicle. Polysaccharides are generally included in these formulations in order to increase the stability and/or applicability of the carrier. In this review, the main biomedical applications of Albumins as drug delivery systems are first presented. Secondly, the differences between BSA and HSA are highlighted, exploring the similarities and differences between these proteins and their interaction with polysaccharides, both in solution and adsorbed at interfaces. Finally, the use of Albumins as emulsifiers for emulsion-based delivery systems, concretely as Liquid Lipid Nanocapsules (LLNs), is revised and discussed in terms of the differences encountered in the molecular structure and in the interfacial properties. The specific case of Hyaluronic Acid is considered as a promising additive with important applications in biomedicine. The literature works are thoroughly discussed highlighting similarities and differences between BSA and HSA and their interaction with polysaccharides encountered at different structural levels, hence providing routes to control the optimal design of delivery systems.

Article	Year
Distributed service-based approach for sensor data fusion in IoT environments. Sensors (Basel, Switzerland)\| PubMed ID: 25320907	2014
Path Loss Determination Using Linear and Cubic Regression Inside a Classic Tomato Greenhouse. International journal of environmental research and public health\| PubMed ID: 31108838	2019
Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy. Pharmaceutics\| PubMed ID: 33143001	2020
Empirical Model of Radio Wave Propagation in the Presence of Vegetation inside Greenhouses Using Regularized Regressions. Sensors (Basel, Switzerland)\| PubMed ID: 33228055	2020
Applications of serum albumins in delivery systems: Differences in interfacial behaviour and interacting abilities with polysaccharides. Advances in colloid and interface science\| PubMed ID: 33667972	2021

Juan Antonio Holgado-Terriza

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