/
/
In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Department of Applied Physics, Faculty of Sciences, Campus de Fuentenueva,University of Granada, 2Department of Physical Chemistry, Faculty of Pharmacy, Campus de Cartuja,University of Granada, 3Department of Software Engineering, School of Computer and Telecommunication Engineering, Campus de Aynadamar,University of Granada
Chapters
- 00:05Introduction
- 02:22Calibration of the OCTOPUS
- 03:49Programming One Experimental Process in DINATEN for Each Digestive Step
- 05:51Setting up the Experiment
- 06:41Results: Gastric Digestion, Intestinal Digestion, and Complete Dynamic Gastrointestinal Digestion Profiles and Final Values of Gastrointestinal Digestion
- 09:22Conclusion
A pendant drop surface film balance implemented with a multi-subphase exchange, nicknamed the OCTOPUS, allows for mimicking digestive conditions by the sequential subphase exchange of the original bulk solution with simulated gastrointestinal fluids. The simulated in vitro digestion is monitored by recording in situ the interfacial tension of the digested interfacial layer.
