Glen F. Tibbits

Department of Biomedical Physiology and Kinesiology, Simon Fraser University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2022

Other Publications

Article	Year
Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping. Stem cells translational medicine\| PubMed ID: 32927497	2021
Ontogeny of excitation-contraction coupling in the mammalian heart. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology\| PubMed ID: 12095856	2002
Beating the cold: the functional evolution of troponin C in teleost fish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology\| PubMed ID: 12095861	2002
Determinants of cardiac Na(+)/Ca(2+) exchanger temperature dependence: NH(2)-terminal transmembrane segments. American journal of physiology. Cell physiology\| PubMed ID: 12107061	2002
Temperature dependence of cardiac Na+/Ca2+ exchanger. Annals of the New York Academy of Sciences\| PubMed ID: 12502547	2002
Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II. American journal of physiology. Cell physiology\| PubMed ID: 12519747	2003
Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C. Biochemistry\| PubMed ID: 12767223	2003
Deconvolution of confocal images of dihydropyridine and ryanodine receptors in developing cardiomyocytes. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 15064297	2004
Na+/Ca2+ exchange activity in neonatal rabbit ventricular myocytes. American journal of physiology. Cell physiology\| PubMed ID: 15317663	2005
Phylogeny of Na+/Ca2+ exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species. Physiological genomics\| PubMed ID: 15741504	2005
cDNA cloning and expression of the cardiac Na+/Ca2+ exchanger from Mozambique tilapia (Oreochromis mossambicus) reveal a teleost membrane transporter with mammalian temperature dependence. The Journal of biological chemistry\| PubMed ID: 15937330	2005
L-type Ca2+ channel function and expression in neonatal rabbit ventricular myocytes. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16339821	2006
Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development. Biophysical journal\| PubMed ID: 17557789	2007
SR Ca2+ refilling upon depletion and SR Ca2+ uptake rates during development in rabbit ventricular myocytes. American journal of physiology. Cell physiology\| PubMed ID: 17928539	2007
Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells. The Journal of physiology\| PubMed ID: 18033814	2008
Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery. Electrophoresis\| PubMed ID: 18072214	2007
Ontogeny of Ca2+-induced Ca2+ release in rabbit ventricular myocytes. American journal of physiology. Cell physiology\| PubMed ID: 18094144	2008
Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility. Physiological genomics\| PubMed ID: 18285522	2008
Gene structure evolution of the Na+-Ca2+ exchanger (NCX) family. BMC evolutionary biology\| PubMed ID: 18447948	2008
Characterization of zebrafish (Danio rerio) NCX4: a novel NCX with distinct electrophysiological properties. American journal of physiology. Cell physiology\| PubMed ID: 18971388	2009
Distribution patterns of the Na+-Ca2+ exchanger and caveolin-3 in developing rabbit cardiomyocytes. Cell calcium\| PubMed ID: 19250668	2009
Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs. The Journal of general physiology\| PubMed ID: 20421371	2010
Calcium handling in zebrafish ventricular myocytes. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 20926764	2011
Colocalization of voltage-gated Na+ channels with the Na+/Ca2+ exchanger in rabbit cardiomyocytes during development. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20971761	2011
Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation. Journal of molecular biology\| PubMed ID: 21920370	2011
The structure of cardiac troponin C regulatory domain with bound Cd2+ reveals a closed conformation and unique ion coordination. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 23633581	2013
Adult teleost heart expresses two distinct troponin C paralogs: cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner. Physiological genomics\| PubMed ID: 23881286	2013
Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*. PloS one\| PubMed ID: 24260207	2013
Phenotype-dependent role of the L-type calcium current in embryonic stem cell derived cardiomyocytes. American journal of stem cells\| PubMed ID: 24660113	2014
Optical mapping of the electrical activity of isolated adult zebrafish hearts: acute effects of temperature. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 24671241	2014
Morphological phenotyping of mouse hearts using optical coherence tomography. Journal of biomedical optics\| PubMed ID: 25393967	2014
Construction and use of a zebrafish heart voltage and calcium optical mapping system, with integrated electrocardiogram and programmable electrical stimulation. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 25740339	2015
Functional Assessment of Cardiac Responses of Adult Zebrafish (Danio rerio) to Acute and Chronic Temperature Change Using High-Resolution Echocardiography. PloS one\| PubMed ID: 26730947	2016
Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC. Genome biology and evolution\| PubMed ID: 26979795	2016
Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC. Biophysical journal\| PubMed ID: 27410732	2016
Ischemia-reperfusion destabilizes rhythmicity in immature atrioventricular pacemakers: A predisposing factor for postoperative arrhythmias in neonate rabbits. Heart rhythm\| PubMed ID: 27451283	2016
The Zebrafish Heart as a Model of Mammalian Cardiac Function. Reviews of physiology, biochemistry and pharmacology\| PubMed ID: 27538987	2016
Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome. PloS one\| PubMed ID: 27824871	2016
Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca-sensitizing mutations. The Journal of biological chemistry\| PubMed ID: 28533433	2017
Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue. Scientific reports\| PubMed ID: 28706272	2017
Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis. Circulation. Cardiovascular genetics\| PubMed ID: 28807990	2017
pH recovery from a proton load in rat cardiomyocytes: effects of chronic exercise. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 29101173	2018
Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis. Forensic science international\| PubMed ID: 29331839	2018
Zebrafish as a model of mammalian cardiac function: Optically mapping the interplay of temperature and rate on voltage and calcium dynamics. Progress in biophysics and molecular biology\| PubMed ID: 30017908	2018
ROCK2 promotes ryanodine receptor phosphorylation and arrhythmic calcium release in diabetic cardiomyocytes. International journal of cardiology\| PubMed ID: 30728103	2019
In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm. Scientific reports\| PubMed ID: 30765726	2019
In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30886088	2019
Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes. Stem cell reports\| PubMed ID: 31031187	2019
Physiological phenotyping of the adult zebrafish heart. Marine genomics\| PubMed ID: 31451352	2020
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 31664867	2019
The hERG channel activator, RPR260243, enhances protective current early in the refractory period reducing arrhythmogenicity in zebrafish hearts. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 32559136	2020
Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes. Scientific reports\| PubMed ID: 32587261	2020
Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome. Frontiers in physiology\| PubMed ID: 33519527	2020
Binding of calcium and magnesium to human cardiac troponin C. The Journal of biological chemistry\| PubMed ID: 33548225	2021
Atrial-specific hiPSC-derived cardiomyocytes in drug discovery and disease modeling. Methods (San Diego, Calif.)\| PubMed ID: 34144175	2022
Investigating inherited arrhythmias using hiPSC-derived cardiomyocytes. Methods (San Diego, Calif.)\| PubMed ID: 34197925	2022
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243. The Journal of general physiology\| PubMed ID: 34398210	2021
Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: A Translational Perspective for the Clinician-Scientist. International journal of molecular sciences\| PubMed ID: 34502196	2021
Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia. Current protocols\| PubMed ID: 34958715	2021
Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T () Variant I79N. Frontiers in cell and developmental biology\| PubMed ID: 34977031	2021
RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes. Stem cell reports\| PubMed ID: 35364012	2022
The effect of Mg on Ca binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants. The FEBS journal\| PubMed ID: 35838319	2022
Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation. Frontiers in cardiovascular medicine\| PubMed ID: 36061558	2022