Sunil R. Lakhani

UQ Centre for Clinical Research, The University of Queensland

Affiliated withThe University of Queensland Royal Brisbane Women's Hospital

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2022

Other Publications

Article	Year
Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16033833	2005
The management of lobular carcinoma in situ (LCIS). Is LCIS the same as ductal carcinoma in situ (DCIS)? European journal of cancer (Oxford, England : 1990)\| PubMed ID: 16876991	2006
Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival. Breast cancer research : BCR\| PubMed ID: 17217540	2007
Current and future approach to the pathologist's assessment for targeted therapy in breast cancer. Pathology\| PubMed ID: 19089744	2009
Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact. Future oncology (London, England)\| PubMed ID: 19284381	2009
Pathology of hereditary breast cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 20436502	2010
The contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriers. Familial cancer\| PubMed ID: 20577821	2010
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast cancer research : BCR\| PubMed ID: 20604919	2010
Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges. Human pathology\| PubMed ID: 21106225	2011
Molecular classification of breast cancer: is it time to pack up our microscopes? Pathology\| PubMed ID: 21240058	2011
Phenotype-genotype correlation in familial breast cancer. Journal of mammary gland biology and neoplasia\| PubMed ID: 21400086	2011
Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization. Endocrine pathology\| PubMed ID: 21499728	2011
Molecular aspects of breast cancer metastasis to the brain. Genetics research international\| PubMed ID: 22567347	2011
Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression. Breast cancer research and treatment\| PubMed ID: 22718308	2012
Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer. Molecular cancer therapeutics\| PubMed ID: 22807578	2012
Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors. PloS one\| PubMed ID: 22815804	2012
Expression profiling of archival tumors for long-term health studies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23136189	2012
MicroRNA-182-5p targets a network of genes involved in DNA repair. RNA (New York, N.Y.)\| PubMed ID: 23249749	2013
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature genetics\| PubMed ID: 23535731	2013
In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PloS one\| PubMed ID: 23750209	2013
Signatures of mutational processes in human cancer. Nature\| PubMed ID: 23945592	2013
Metastatic progression of breast cancer: insights from 50 years of autopsies. The Journal of pathology\| PubMed ID: 24122263	2014
Is the one-step nucleic acid amplification assay better for intra-operative assessment of breast sentinel nodes? ANZ journal of surgery\| PubMed ID: 24397867	2014
Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation. PloS one\| PubMed ID: 24489791	2014
Molecular classification of breast cancer. Virchows Archiv : an international journal of pathology\| PubMed ID: 24878755	2014
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget\| PubMed ID: 25668816	2015
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype. Nature communications\| PubMed ID: 25813983	2015
Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics. Breast cancer research : BCR\| PubMed ID: 25849106	2015
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PloS one\| PubMed ID: 25969993	2015
An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomas. The Journal of pathology\| PubMed ID: 26510554	2016
Novel highly specific anti-periostin antibodies uncover the functional importance of the fascilin 1-1 domain and highlight preferential expression of periostin in aggressive breast cancer. International journal of cancer\| PubMed ID: 26619948	2016
TGFβ isoforms and receptors mRNA expression in breast tumours: prognostic value and clinical implications. BMC cancer\| PubMed ID: 26703884	2015
High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations. Breast cancer research : BCR\| PubMed ID: 26861772	2016
Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. American journal of human genetics\| PubMed ID: 27087319	2016
Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature\| PubMed ID: 27135926	2016
The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Scientific reports\| PubMed ID: 27148852	2016
Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 27363491	2016
Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human molecular genetics\| PubMed ID: 27378691	2016
SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer. Oncotarget\| PubMed ID: 27637080	2016
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration. Nature communications\| PubMed ID: 27666519	2016
'Omics Approaches in Breast Cancer Research and Clinical Practice. Advances in anatomic pathology\| PubMed ID: 27740960	2016
Current topics in breast pathology: expert perspectives. Pathology\| PubMed ID: 28069256	2017
Environmental factors in breast cancer invasion: a mathematical modelling review. Pathology\| PubMed ID: 28081961	2017
Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context. International journal of molecular sciences\| PubMed ID: 28098771	2017
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. Nature genetics\| PubMed ID: 28112740	2017
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. Nature medicine\| PubMed ID: 28288110	2017
Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 28338653	2017
Relationship of the Breast Ductal Carcinoma Immune Microenvironment with Clinicopathological and Genetic Features. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 28611201	2017
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast cancer research and treatment\| PubMed ID: 28889351	2018
Association analysis identifies 65 new breast cancer risk loci. Nature\| PubMed ID: 29059683	2017
Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology. The Journal of pathology\| PubMed ID: 29344954	2018
Expression of MAGE-A and NY-ESO-1 cancer/testis antigens is enriched in triple-negative invasive breast cancers. Histopathology\| PubMed ID: 29465777	2018
Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast cancer research and treatment\| PubMed ID: 29468485	2018
CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO molecular medicine\| PubMed ID: 30108112	2018
Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study. The journal of pathology. Clinical research\| PubMed ID: 30246500	2019
Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications. The Journal of pathology\| PubMed ID: 30350370	2019
Recent advances in breast cancer research impacting clinical diagnostic practice. The Journal of pathology\| PubMed ID: 30426489	2019
Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature\| PubMed ID: 30659290	2019
The circular RNome of primary breast cancer. Genome research\| PubMed ID: 30692147	2019
Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens as a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks. Respiration; international review of thoracic diseases\| PubMed ID: 30731462	2019
Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer. JCI insight\| PubMed ID: 30830863	2019
Innovative Therapeutic Strategies for Effective Treatment of Brain Metastases. International journal of molecular sciences\| PubMed ID: 30875730	2019
Proteomic Analysis of the Breast Cancer Brain Metastasis Microenvironment. International journal of molecular sciences\| PubMed ID: 31121957	2019
A Molecular and Morphological Deep-Dive Into Metaplastic Breast Cancers. Cancer informatics\| PubMed ID: 31205411	2019
LobSig is a multigene predictor of outcome in invasive lobular carcinoma. NPJ breast cancer\| PubMed ID: 31263747	2019
Breast Cancer Heterogeneity in Primary and Metastatic Disease. Advances in experimental medicine and biology\| PubMed ID: 31456181	2019
Non-coding RNAs underlie genetic predisposition to breast cancer. Genome biology\| PubMed ID: 31910864	2020
The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily p... The Journal of pathology\| PubMed ID: 32129476	2020
Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer. Cancers\| PubMed ID: 32244556	2020
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer. Life science alliance\| PubMed ID: 32423906	2020
Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor-Positive Breast Cancer. JAMA network open\| PubMed ID: 32633764	2020
Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1. Frontiers in cell and developmental biology\| PubMed ID: 32766238	2020
Using whole-genome sequencing data to derive the homologous recombination deficiency scores. NPJ breast cancer\| PubMed ID: 32818150	2020
Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1. British journal of cancer\| PubMed ID: 32939056	2020
Clinicopathologic significance of nuclear HER4 and phospho-YAP(S) in human breast cancers and matching brain metastases. Therapeutic advances in medical oncology\| PubMed ID: 33014146	2020
The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence. British journal of cancer\| PubMed ID: 33024263	2021
Lobular carcinoma in situ: diagnostic criteria and molecular correlates. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 33024303	2021
Phenotypic drift in metastatic progression of breast cancer: A case report with histologically heterogeneous lesions that are clonally related. Clinical case reports\| PubMed ID: 33363813	2020
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype. Breast cancer research : BCR\| PubMed ID: 33413533	2021
An Update on the Molecular Pathology of Metaplastic Breast Cancer. Breast cancer (Dove Medical Press)\| PubMed ID: 33664587	2021
Spatial profiling technologies and applications for brain cancers. Expert review of molecular diagnostics\| PubMed ID: 33685321	2021
Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development. Cancers\| PubMed ID: 33917078	2021
The Genomic Landscape of Lobular Breast Cancer. Cancers\| PubMed ID: 33919581	2021
Characterization of Immune Cell Subsets of Tumor Infiltrating Lymphocytes in Brain Metastases. Biology\| PubMed ID: 34064871	2021
Altered Calcium Influx Pathways in Cancer-Associated Fibroblasts. Biomedicines\| PubMed ID: 34208665	2021
Correction: McCart Reed et al. The Genomic Landscape of Lobular Breast Cancer. 2021, , 1950. Cancers\| PubMed ID: 34439402	2021
Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non-Small-Cell Lung Cancer. Cancers\| PubMed ID: 34572879	2021
Blood-Derived Extracellular Vesicle-Associated miR-3182 Detects Non-Small Cell Lung Cancer Patients. Cancers\| PubMed ID: 35008424	2022
Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content. BMC cancer\| PubMed ID: 35057759	2022
Landscape of Epidermal Growth Factor Receptor Heterodimers in Brain Metastases. Cancers\| PubMed ID: 35158800	2022
Emerging Biomarkers for Diagnosis, Prevention and Treatment of Brain Metastases-From Biology to Clinical Utility. Diseases (Basel, Switzerland)\| PubMed ID: 35225863	2022
N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease. BMC cancer\| PubMed ID: 35346112	2022
Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. NPJ breast cancer\| PubMed ID: 35501337	2022
The increasing importance of pathology in modern clinical trial conduct: OlympiA as a case in point. Pathology\| PubMed ID: 35778289	2022