David Kleinfeld

Department of Physics, University of California, San Diego

Affiliated withUniversity of California, San Diego

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 128	2012
Publication title Cited by 9	2015
Publication title Cited by 17	2016

Other Publications

Article	Year
Cortical imaging through the intact mouse skull using two-photon excitation laser scanning microscopy. Microscopy research and technique\| PubMed ID: 11877806	2002
Coherent electrical activity between vibrissa sensory areas of cerebellum and neocortex is enhanced during free whisking. Journal of neurophysiology\| PubMed ID: 11929931	2002
Adaptive filtering of vibrissa input in motor cortex of rat. Neuron\| PubMed ID: 12086648	2002
Spectral mixing of rhythmic neuronal signals in sensory cortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12403828	2002
Closed-loop neuronal computations: focus on vibrissa somatosensation in rat. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 12466215	2003
Rhythmic whisking by rat: retraction as well as protraction of the vibrissae is under active muscular control. Journal of neurophysiology\| PubMed ID: 12522163	2003
All-optical histology using ultrashort laser pulses. Neuron\| PubMed ID: 12848930	2003
Unilateral vibrissa contact: changes in amplitude but not timing of rhythmic whisking. Somatosensory & motor research\| PubMed ID: 12850826	2003
Vibrissa movement elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory whisking. Journal of neurophysiology\| PubMed ID: 12904336	2003
Reversing cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14671315	2003
Imaging reveals synaptic targets of a swim-terminating neuron in the leech CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14673004	2003
Frisking the whiskers: patterned sensory input in the rat vibrissa system. Neuron\| PubMed ID: 14741099	2004
Developmental regulation of active and passive membrane properties in rat vibrissa motoneurones. The Journal of physiology\| PubMed ID: 14766934	2004
Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15297618	2004
Current flow in vibrissa motor cortex can phase-lock with exploratory rhythmic whisking in rat. Journal of neurophysiology\| PubMed ID: 15331651	2004
Positive feedback in a brainstem tactile sensorimotor loop. Neuron\| PubMed ID: 15694330	2005
Activation of nucleus basalis facilitates cortical control of a brain stem motor program. Journal of neurophysiology\| PubMed ID: 15728764	2005
From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging. PLoS biology\| PubMed ID: 16207078	2005
Coding of stimulus frequency by latency in thalamic networks through the interplay of GABAB-mediated feedback and stimulus shape. Journal of neurophysiology\| PubMed ID: 16267113	2006
Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLoS biology\| PubMed ID: 16379497	2006
Science is an adventure, not a battle. Nature\| PubMed ID: 16397477	2006
Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nature methods\| PubMed ID: 16432519	2006
MPScope: a versatile software suite for multiphoton microscopy. Journal of neuroscience methods\| PubMed ID: 16621010	2006
Seeing what the mouse sees with its vibrissae: a matter of behavioral state. Neuron\| PubMed ID: 16701202	2006
Exploratory whisking by rat is not phase locked to the hippocampal theta rhythm. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16775139	2006
Active sensation: insights from the rodent vibrissa sensorimotor system. Current opinion in neurobiology\| PubMed ID: 16837190	2006
Penetrating arterioles are a bottleneck in the perfusion of neocortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17190804	2007
Is there a common origin to surround-inhibition as seen through electrical activity versus hemodynamic changes? Focus on "Duration-dependent response in SI to vibrotactile stimulation in squ... Journal of neurophysiology\| PubMed ID: 17215499	2007
Active spatial perception in the vibrissa scanning sensorimotor system. PLoS biology\| PubMed ID: 17227143	2007
Large two-photon absorptivity of hemoglobin in the infrared range of 780-880 nm. The Journal of chemical physics\| PubMed ID: 17228976	2007
Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17442830	2007
Wilder Penfield in the age of YouTube: visualizing the sequential activation of sensorimotor areas across neocortex. Neuron\| PubMed ID: 18054853	2007
Biomechanics of the vibrissa motor plant in rat: rhythmic whisking consists of triphasic neuromuscular activity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18367610	2008
'Where' and 'what' in the whisker sensorimotor system. Nature reviews. Neuroscience\| PubMed ID: 18641667	2008
Finding coherence in spontaneous oscillations. Nature neuroscience\| PubMed ID: 18725901	2008
Texture coding in the rat whisker system: slip-stick versus differential resonance. PLoS biology\| PubMed ID: 18752354	2008
Advancing multifocal nonlinear microscopy: development and application of a novel multibeam Yb:KGd(WO4)2 oscillator. Optics express\| PubMed ID: 18958037	2008
Chapter 10. In vivo measurements of blood flow and glial cell function with two-photon laser-scanning microscopy. Methods in enzymology\| PubMed ID: 19007667	2008
Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19118167	2008
Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 19174826	2009
Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems. Current opinion in biotechnology\| PubMed ID: 19269159	2009
Phase-to-rate transformations encode touch in cortical neurons of a scanning sensorimotor system. Nature neuroscience\| PubMed ID: 19270688	2009
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS computational biology\| PubMed ID: 19325892	2009
Acute vascular disruption and aquaporin 4 loss after stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 19372455	2009
Rapid determination of particle velocity from space-time images using the Radon transform. Journal of computational neuroscience\| PubMed ID: 19459038	2010
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. The Journal of clinical investigation\| PubMed ID: 19809162	2009
Severe blood-brain barrier disruption and surrounding tissue injury. Stroke; a journal of cerebral circulation\| PubMed ID: 19893002	2009
Enter the ratrix. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19906991	2009
Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19923289	2009
An in vivo biosensor for neurotransmitter release and in situ receptor activity. Nature neuroscience\| PubMed ID: 20010818	2010
Optimizing the fluorescent yield in two-photon laser scanning microscopy with dispersion compensation. Optics express\| PubMed ID: 20588500	2010
Automatic identification of fluorescently labeled brain cells for rapid functional imaging. Journal of neurophysiology\| PubMed ID: 20610792	2010
Topological basis for the robust distribution of blood to rodent neocortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20616030	2010
Temporally focused femtosecond laser pulses for low numerical aperture micromachining through optically transparent materials. Optics express\| PubMed ID: 20721196	2010
Chronic optical access through a polished and reinforced thinned skull. Nature methods\| PubMed ID: 20966916	2010
Spatio-temporally focused femtosecond laser pulses for nonreciprocal writing in optically transparent materials. Optics express\| PubMed ID: 21164813	2010
Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors. PloS one\| PubMed ID: 21305050	2011
Photon counting, censor corrections, and lifetime imaging for improved detection in two-photon microscopy. Journal of neurophysiology\| PubMed ID: 21471395	2011
Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21536897	2011
A guide to delineate the logic of neurovascular signaling in the brain. Frontiers in neuroenergetics\| PubMed ID: 21559095	2011
Quality metrics to accompany spike sorting of extracellular signals. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21677152	2011
Primary motor cortex reports efferent control of vibrissa motion on multiple timescales. Neuron\| PubMed ID: 22017992	2011
Large-scale automated histology in the pursuit of connectomes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22072665	2011
Neuronal basis for object location in the vibrissa scanning sensorimotor system. Neuron\| PubMed ID: 22078505	2011
Prospect for feedback guided surgery with ultra-short pulsed laser light. Current opinion in neurobiology\| PubMed ID: 22088392	2012
Sniffing and whisking in rodents. Current opinion in neurobiology\| PubMed ID: 22177596	2011
Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 22293983	2012
Interferometric detection of action potentials. Cold Spring Harbor protocols\| PubMed ID: 22383643	2012
Dorsorostral snout muscles in the rat subserve coordinated movement for whisking and sniffing. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 22641389	2012
Vectorization of optically sectioned brain microvasculature: learning aids completion of vascular graphs by connecting gaps and deleting open-ended segments. Medical image analysis\| PubMed ID: 22854035	2012
The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nature neuroscience\| PubMed ID: 23242312	2013
All-optical in situ histology of brain tissue with femtosecond laser pulses. Cold Spring Harbor protocols\| PubMed ID: 23547156	2013
Hierarchy of orofacial rhythms revealed through whisking and breathing. Nature\| PubMed ID: 23624373	2013
The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow. Nature neuroscience\| PubMed ID: 23749145	2013
Two-photon imaging of blood flow in the rat cortex. Cold Spring Harbor protocols\| PubMed ID: 23906919	2013
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nature neuroscience\| PubMed ID: 23995068	2013
All-optical osteotomy to create windows for transcranial imaging in mice. Optics express\| PubMed ID: 24104230	2013
The challenge of connecting the dots in the B.R.a.I.N. Neuron\| PubMed ID: 24139032	2013
Mediation of muscular control of rhinarial motility in rats by the nasal cartilaginous skeleton. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 24249396	2013
Optically induced occlusion of single blood vessels in rodent neocortex. Cold Spring Harbor protocols\| PubMed ID: 24298038	2013
Spectral methods for functional brain imaging. Cold Spring Harbor protocols\| PubMed ID: 24591695	2014
More than a rhythm of life: breathing as a binder of orofacial sensation. Nature neuroscience\| PubMed ID: 24762718	2014
How the brainstem controls orofacial behaviors comprised of rhythmic actions. Trends in neurosciences\| PubMed ID: 24890196	2014
Activation and measurement of free whisking in the lightly anesthetized rodent. Nature protocols\| PubMed ID: 24992095	2014
Muscles involved in naris dilation and nose motion in rat. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 25257748	2015
Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex. Nature methods\| PubMed ID: 25344639	2014
The Musculature That Drives Active Touch by Vibrissae and Nose in Mice. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 25408106	2014
Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. The Journal of comparative neurology\| PubMed ID: 25503925	2015
Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 25705966	2015
Fluorescently Labeled Peptide Increases Identification of Degenerated Facial Nerve Branches during Surgery and Improves Functional Outcome. PloS one\| PubMed ID: 25751149	2015
Deflection of a vibrissa leads to a gradient of strain across mechanoreceptors in a mystacial follicle. Journal of neurophysiology\| PubMed ID: 25855692	2015
The Brainstem Oscillator for Whisking and the Case for Breathing as the Master Clock for Orofacial Motor Actions. Cold Spring Harbor symposia on quantitative biology\| PubMed ID: 25876629	2015