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A Polished and Reinforced Thinned-skull Window for Long-term Imaging of the Mouse Brain
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
A Polished and Reinforced Thinned-skull Window for Long-term Imaging of the Mouse Brain

A Polished and Reinforced Thinned-skull Window for Long-term Imaging of the Mouse Brain

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09:49 min

March 07, 2012

DOI:

09:49 min
March 07, 2012

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Summary

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We present a method to form an imaging window in the mouse skull that spans millimeters and is stable for months without inflammation of the brain. This method is well suited for longitudinal studies of blood flow, cellular dynamics, and cell/vascular structure using two-photon microscopy.

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