Daryl A. Bosco

Department of Neurology, University of Massachusetts Chan Medical School

Affiliated withUniversity of Massachusetts Chan Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2022
Publication title Cited by 5	2023

Other Publications

Article	Year
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules. Human molecular genetics\| PubMed ID: 20699327	2010
Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets. CNS & neurological disorders drug targets\| PubMed ID: 20942785	2010
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nature neuroscience\| PubMed ID: 20953194	2010
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics. Molecular neurodegeneration\| PubMed ID: 24090136	2013
Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis. The Journal of biological chemistry\| PubMed ID: 25164820	2014
Functions of FUS/TLS from DNA repair to stress response: implications for ALS. ASN neuro\| PubMed ID: 25289647	2014
Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26056300	2015
ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation. Scientific reports\| PubMed ID: 28273913	2017
Translation dysregulation in neurodegenerative disorders. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30504142	2018
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for mRNA processing. The Journal of biological chemistry\| PubMed ID: 31092554	2019
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nature neuroscience\| PubMed ID: 34059832	2021
ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34074767	2021
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons. Neuron\| PubMed ID: 35276083	2022
Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons. International journal of molecular sciences\| PubMed ID: 36555655	2022
Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies. Journal of molecular biology\| PubMed ID: 36690069	2023