Magnus Stougaard

Department of Clinical Medicine, Aarhus University

Affiliated withAarhus University VPCIR Biosciences ApS Aarhus University Hospital

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2022

Other Publications

Article	Year
A new enzymatic route for production of long 5'-phosphorylated oligonucleotides using suicide cassettes and rolling circle DNA synthesis. BMC biotechnology\| PubMed ID: 17705815	2007
In situ detection of non-polyadenylated RNA molecules using Turtle Probes and target primed rolling circle PRINS. BMC biotechnology\| PubMed ID: 17945012	2007
Detection of short repeated genomic sequences on metaphase chromosomes using padlock probes and target primed rolling circle DNA synthesis. BMC molecular biology\| PubMed ID: 17997865	2007
Single-molecule detection of human topoisomerase I cleavage-ligation activity. ACS nano\| PubMed ID: 19206270	2009
Multiplexed detection of site specific recombinase and DNA topoisomerase activities at the single molecule level. ACS nano\| PubMed ID: 19950974	2009
Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21927767	2011
Detection of single enzymatic events in rare or single cells using microfluidics. ACS nano\| PubMed ID: 21936557	2011
Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference\| PubMed ID: 22255034	2011
Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement. ACS nano\| PubMed ID: 23121492	2012
DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I. Sensors (Basel, Switzerland)\| PubMed ID: 23529147	2013
Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor. Biosensors & bioelectronics\| PubMed ID: 23693093	2013
DNA-based nanosensors for next-generation clinical diagnostics via detection of enzyme activity. Expert review of molecular diagnostics\| PubMed ID: 24308335	2014
Topoisomerase I as a biomarker: detection of activity at the single molecule level. Sensors (Basel, Switzerland)\| PubMed ID: 24434877	2014
Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I. PloS one\| PubMed ID: 24960044	2014
In-situ hybridization-based quantification of hTR: a possible biomarker in malignant melanoma. Histopathology\| PubMed ID: 25601620	2015
The parental origin correlates with the karyotype of human embryos developing from tripronuclear zygotes. Clinical and experimental reproductive medicine\| PubMed ID: 25874169	2015
Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations. Nanoscale\| PubMed ID: 25963854	2015
Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue. Experimental and molecular pathology\| PubMed ID: 25987486	2015
Microfluidics-Enabled Enzyme Activity Measurement in Single Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26542724	2015
Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26699424	2016
Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines. BMC cancer\| PubMed ID: 26801902	2016
Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons. Sensors (Basel, Switzerland)\| PubMed ID: 27854277	2016
Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker. Nanoscale\| PubMed ID: 27934981	2017
Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study. Nanoscale\| PubMed ID: 28094391	2017
The Effects of Dithiothreitol on DNA. Sensors (Basel, Switzerland)\| PubMed ID: 28538659	2017
Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events. Nucleic acids research\| PubMed ID: 28541438	2017
Quantification of microRNA-21 and microRNA-125b in melanoma tissue. Melanoma research\| PubMed ID: 28614272	2017
On-slide detection of enzymatic activities in selected single cells. Nanoscale\| PubMed ID: 28872165	2017
Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5. Cancer genomics & proteomics\| PubMed ID: 29496689	2018
Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker. Scientific reports\| PubMed ID: 29515150	2018
Telomerase reverse transcriptase promoter mutations and solar elastosis in cutaneous melanoma. Melanoma research\| PubMed ID: 29570169	2018
Detection of mRNA of Telomerase Protein in Benign Naevi and Melanomas Using RNAscope. Applied immunohistochemistry & molecular morphology : AIMM\| PubMed ID: 30095463	2020
A new DNA sensor system for specific and quantitative detection of mycobacteria. Nanoscale\| PubMed ID: 30556557	2019
Rapid and Efficient Gene Deletion by CRISPR/Cas9. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30912049	2019
Distinguishing recurrence and new primary tumor as well as the origin of neck metastases in head and neck cancer clinical trials by targeted DNA sequencing. Acta oncologica (Stockholm, Sweden)\| PubMed ID: 31271080	2019
Intra-individual variation of circulating tumour DNA in lung cancer patients. Molecular oncology\| PubMed ID: 31306545	2019
Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts. Acta oncologica (Stockholm, Sweden)\| PubMed ID: 31510843	2019
Enzymatic activity in single cells. Methods in enzymology\| PubMed ID: 31668235	2019
Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC cancer\| PubMed ID: 31783818	2019
FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 32145268	2020
Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities. Cancers\| PubMed ID: 32423158	2020
Targeted next generation sequencing panel for HPV genotyping in cervical cancer. Experimental and molecular pathology\| PubMed ID: 33171155	2021
SNP-based detection of allelic imbalance: A novel approach for identifying KIAA1549-BRAF fusion in pilocytic astrocytoma using DNA sequencing. Experimental and molecular pathology\| PubMed ID: 33626378	2021
Frequently used quantitative polymerase chain reaction-based methods overlook potential clinically relevant genetic alterations in epidermal growth factor receptor compared with next-generat... Human pathology\| PubMed ID: 34153308	2021
A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors. Sensors (Basel, Switzerland)\| PubMed ID: 34300575	2021
Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1. Pharmaceutics\| PubMed ID: 34452216	2021
TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 34974222	2022
A targeted expression panel for classification, gene fusion detection and PD-L1 measurements - Can molecular profiling replace immunohistochemistry in non-small cell lung cancer? Experimental and molecular pathology\| PubMed ID: 35093316	2022
Targeted Next Generation Sequencing for Human Papillomavirus Genotyping in Cervical Liquid-Based Cytology Samples. Cancers\| PubMed ID: 35158920	2022
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation. Nucleic acids research\| PubMed ID: 35687110	2022
The Diagnostic Value of Circulating Cell-Free HPV DNA in Plasma from Cervical Cancer Patients. Cells\| PubMed ID: 35883612	2022
The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation. Translational psychiatry\| PubMed ID: 35941107	2022
Impact of new molecular criteria on diagnosis and survival of adult glioma patients. IBRO neuroscience reports\| PubMed ID: 36204252	2022
Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts. Sensors (Basel, Switzerland)\| PubMed ID: 36298113	2022
Prognostic value of mutations, mutations and PD-L1 expression among lung adenocarcinomas treated with immunotherapy. Journal of clinical pathology\| PubMed ID: 36410939	2022