Birgitta R. Knudsen

Department of Molecular Biology and Genetics, Aarhus University

Affiliated withAarhus University VPCIR Biosciences ApS

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2022

Other Publications

Article	Year
Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells. The Journal of cell biology\| PubMed ID: 11927602	2002
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Nucleic acids research\| PubMed ID: 17827209	2007
Single-molecule detection of human topoisomerase I cleavage-ligation activity. ACS nano\| PubMed ID: 19206270	2009
Multiplexed detection of site specific recombinase and DNA topoisomerase activities at the single molecule level. ACS nano\| PubMed ID: 19950974	2009
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Nucleic acids research\| PubMed ID: 20855291	2011
Topoisomerase I deficiency results in chromosomal alterations in cervical cancer cells. Anticancer research\| PubMed ID: 20944095	2010
Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21927767	2011
Detection of single enzymatic events in rare or single cells using microfluidics. ACS nano\| PubMed ID: 21936557	2011
Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. Molecular biology international\| PubMed ID: 22091414	2011
Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference\| PubMed ID: 22255034	2011
Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement. ACS nano\| PubMed ID: 23121492	2012
DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I. Sensors (Basel, Switzerland)\| PubMed ID: 23529147	2013
Quantum dot-based nanosensors for diagnosis via enzyme activity measurement. Expert review of molecular diagnostics\| PubMed ID: 23638819	2013
Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor. Biosensors & bioelectronics\| PubMed ID: 23693093	2013
Topoisomerase I as a biomarker: detection of activity at the single molecule level. Sensors (Basel, Switzerland)\| PubMed ID: 24434877	2014
Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads. Analytical biochemistry\| PubMed ID: 24525043	2014
Synthesis of fluorosurfactants for emulsion-based biological applications. ACS nano\| PubMed ID: 24646088	2014
Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I. PloS one\| PubMed ID: 24960044	2014
NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection. Nanoscale\| PubMed ID: 25901841	2015
Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations. Nanoscale\| PubMed ID: 25963854	2015
Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue. Experimental and molecular pathology\| PubMed ID: 25987486	2015
Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene. ACS nano\| PubMed ID: 26445172	2015
Microfluidics-Enabled Enzyme Activity Measurement in Single Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26542724	2015
Specific detection of the cleavage activity of mycobacterial enzymes using a quantum dot based DNA nanosensor. Nanoscale\| PubMed ID: 26616006	2016
Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines. BMC cancer\| PubMed ID: 26801902	2016
Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity. European journal of medicinal chemistry\| PubMed ID: 27017547	2016
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. Journal of experimental & clinical cancer research : CR\| PubMed ID: 27029323	2016
DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family. Nanoscale\| PubMed ID: 27341703	2016
Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons. Sensors (Basel, Switzerland)\| PubMed ID: 27854277	2016
Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker. Nanoscale\| PubMed ID: 27934981	2017
Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study. Nanoscale\| PubMed ID: 28094391	2017
The Effects of Dithiothreitol on DNA. Sensors (Basel, Switzerland)\| PubMed ID: 28538659	2017
Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events. Nucleic acids research\| PubMed ID: 28541438	2017
On-slide detection of enzymatic activities in selected single cells. Nanoscale\| PubMed ID: 28872165	2017
Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5. Cancer genomics & proteomics\| PubMed ID: 29496689	2018
Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker. Scientific reports\| PubMed ID: 29515150	2018
A new DNA sensor system for specific and quantitative detection of mycobacteria. Nanoscale\| PubMed ID: 30556557	2019
Enzymatic activity in single cells. Methods in enzymology\| PubMed ID: 31668235	2019
Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC cancer\| PubMed ID: 31783818	2019
Synthesis of novel hybrid quinolino[4,3-b][1,5]naphthyridines and quinolino[4,3-b][1,5]naphthyridin-6(5H)-one derivatives and biological evaluation as topoisomerase I inhibitors and antiprol... European journal of medicinal chemistry\| PubMed ID: 32279049	2020
DNA flowerstructure co-localizes with human pathogens in infected macrophages. Nucleic acids research\| PubMed ID: 32402089	2020
Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities. Cancers\| PubMed ID: 32423158	2020
Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents. Bioorganic & medicinal chemistry\| PubMed ID: 33962152	2021
A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors. Sensors (Basel, Switzerland)\| PubMed ID: 34300575	2021
Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B). Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 34451880	2021
Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1. Pharmaceutics\| PubMed ID: 34452216	2021
Synthesis of hybrid phosphorated indenoquinolines and biological evaluation as topoisomerase I inhibitors and antiproliferative agents. Bioorganic & medicinal chemistry letters\| PubMed ID: 34952177	2022
TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 34974222	2022
Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX. Cells\| PubMed ID: 35563813	2022
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation. Nucleic acids research\| PubMed ID: 35687110	2022
Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts. Sensors (Basel, Switzerland)\| PubMed ID: 36298113	2022