Gerard Apodaca

Renal-Electrolyte Division, University of Pittsburgh

Affiliated withUniversity of Pittsburgh University of Pittsburgh School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 2	2022
Publication title	2022
Publication title Cited by 14	2023

Other Publications

Article	Year
Selective perturbation of apical membrane traffic by expression of influenza M2, an acid-activated ion channel, in polarized madin-darby canine kidney cells. Molecular biology of the cell\| PubMed ID: 9725907	1998
Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA. Molecular biology of the cell\| PubMed ID: 10588664	1999
Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1. Molecular biology of the cell\| PubMed ID: 10637309	2000
Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state. Molecular biology of the cell\| PubMed ID: 10712502	2000
Sorting of membrane and fluid at the apical pole of polarized Madin-Darby canine kidney cells. Molecular biology of the cell\| PubMed ID: 10848634	2000
A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network. The EMBO journal\| PubMed ID: 11226177	2001
Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton. Traffic (Copenhagen, Denmark)\| PubMed ID: 11260520	2001
Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells. Molecular biology of the cell\| PubMed ID: 11514615	2001
Na,K-ATPase activity is required for formation of tight junctions, desmosomes, and induction of polarity in epithelial cells. Molecular biology of the cell\| PubMed ID: 11739775	2001
Modulation of membrane traffic by mechanical stimuli. American journal of physiology. Renal physiology\| PubMed ID: 11788431	2002
Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. Molecular biology of the cell\| PubMed ID: 11907265	2002
Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells. American journal of physiology. Renal physiology\| PubMed ID: 12060584	2002
Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12223560	2002
Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis. American journal of physiology. Renal physiology\| PubMed ID: 12426235	2002
Immunoglobulin transport across polarized epithelial cells. Nature reviews. Molecular cell biology\| PubMed ID: 12461560	2002
Disruption of bladder epithelium barrier function after spinal cord injury. American journal of physiology. Renal physiology\| PubMed ID: 12527557	2003
Hydrostatic pressure-regulated ion transport in bladder uroepithelium. American journal of physiology. Renal physiology\| PubMed ID: 12770841	2003
Analysis of hydrostatic pressure-induced changes in umbrella cell surface area. Methods (San Diego, Calif.)\| PubMed ID: 12798135	2003
Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 14684357	2004
Permeabilities of teleost and elasmobranch gill apical membranes: evidence that lipid bilayers alone do not account for barrier function. American journal of physiology. Cell physiology\| PubMed ID: 14998788	2004
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. American journal of physiology. Renal physiology\| PubMed ID: 15068973	2004
The uroepithelium: not just a passive barrier. Traffic (Copenhagen, Denmark)\| PubMed ID: 15086788	2004
Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. The Journal of biological chemistry\| PubMed ID: 15169791	2004
WITHDRAWN: RhoB-dependent modulation of early endocytic traffic in Madin-Darby canine kidney cells. The Journal of biological chemistry\| PubMed ID: 15319429	2007
Selective permeability barrier to urea in shark rectal gland. American journal of physiology. Renal physiology\| PubMed ID: 15727989	2005
Water and solute permeability of rat lung caveolae: high permeabilities explained by acyl chain unsaturation. American journal of physiology. Cell physiology\| PubMed ID: 15728712	2005
Isolation and characterization of the Xenopus oocyte plasma membrane: a new method for studying activity of water and solute transporters. American journal of physiology. Renal physiology\| PubMed ID: 15741609	2005
ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. The Journal of clinical investigation\| PubMed ID: 16110327	2005
MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Molecular biology of the cell\| PubMed ID: 16775013	2006
Apical epidermal growth factor receptor signaling: regulation of stretch-dependent exocytosis in bladder umbrella cells. Molecular biology of the cell\| PubMed ID: 17287395	2007
RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. Traffic (Copenhagen, Denmark)\| PubMed ID: 17547697	2007
Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice. Traffic (Copenhagen, Denmark)\| PubMed ID: 17555536	2007
The uroepithelial-associated sensory web. Kidney international\| PubMed ID: 17667988	2007
Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. The EMBO journal\| PubMed ID: 17673908	2007
Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Molecular biology of the cell\| PubMed ID: 17686995	2007
Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model. American journal of physiology. Renal physiology\| PubMed ID: 18256316	2008
Transcytosis of polymeric immunoglobulin a in polarized Madin-Darby canine kidney cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18369944	2008
Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- mice. Journal of molecular neuroscience : MN\| PubMed ID: 18561033	2008
Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18843107	2008
Distinct apical and basolateral membrane requirements for stretch-induced membrane traffic at the apical surface of bladder umbrella cells. Molecular biology of the cell\| PubMed ID: 18987341	2009
Cell biology and physiology of the uroepithelium. American journal of physiology. Renal physiology\| PubMed ID: 19587142	2009
Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway. The EMBO journal\| PubMed ID: 20461056	2010
Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. American journal of physiology. Renal physiology\| PubMed ID: 20943764	2011
Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. American journal of physiology. Renal physiology\| PubMed ID: 21677144	2011
Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). American journal of physiology. Renal physiology\| PubMed ID: 22129970	2012
Modulation of bladder function by luminal adenosine turnover and A1 receptor activation. American journal of physiology. Renal physiology\| PubMed ID: 22552934	2012
Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Molecular biology of the cell\| PubMed ID: 22553350	2012
Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity. PloS one\| PubMed ID: 22848617	2012
The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PloS one\| PubMed ID: 23029554	2012
Role of membrane traffic in the generation of epithelial cell asymmetry. Nature cell biology\| PubMed ID: 23196841	2012
PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells. PloS one\| PubMed ID: 23342003	2013
A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. Molecular biology of the cell\| PubMed ID: 23389633	2013
Bladder filling and voiding affect umbrella cell tight junction organization and function. American journal of physiology. Renal physiology\| PubMed ID: 23884145	2013
A phosphotyrosine switch for cargo sequestration at clathrin-coated buds. The Journal of biological chemistry\| PubMed ID: 24798335	2014
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells. Molecular biology of the cell\| PubMed ID: 25232007	2014
A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Molecular biology of the cell\| PubMed ID: 25232008	2014
Membrane traffic research: challenges for the next decade. Frontiers in cell and developmental biology\| PubMed ID: 25364759	2014
Measuring receptor recycling in polarized MDCK cells. Methods in cell biology\| PubMed ID: 26360039	2015
Increased urothelial paracellular transport promotes cystitis. American journal of physiology. Renal physiology\| PubMed ID: 26423859	2015
Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport. The Journal of biological chemistry\| PubMed ID: 27432882	2016
Role of Polarity Proteins in the Generation and Organization of Apical Surface Protrusions. Cold Spring Harbor perspectives in biology\| PubMed ID: 28264821	2018
Urothelial proliferation and regeneration after spinal cord injury. American journal of physiology. Renal physiology\| PubMed ID: 28331065	2017
Low-Density Neuronal Cultures from Human Induced Pluripotent Stem Cells. Molecular neuropsychiatry\| PubMed ID: 28879199	2017
RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells. American journal of physiology. Cell physiology\| PubMed ID: 29167152	2018
Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis. Frontiers in systems neuroscience\| PubMed ID: 29706873	2018
Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections. Stem cell research & therapy\| PubMed ID: 29751846	2018
Age-related endolysosome dysfunction in the rat urothelium. PloS one\| PubMed ID: 29883476	2018
Corrigendum: Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis. Frontiers in systems neuroscience\| PubMed ID: 30459568	2018
Urinary K promotes irritative voiding symptoms and pain in the face of urothelial barrier dysfunction. Scientific reports\| PubMed ID: 30940909	2019
Acute spinal cord injury is associated with mitochondrial dysfunction in mouse urothelium. Neurourology and urodynamics\| PubMed ID: 31102563	2019
Expression and distribution of PIEZO1 in the mouse urinary tract. American journal of physiology. Renal physiology\| PubMed ID: 31166705	2019
Expansion and contraction of the umbrella cell apical junctional ring in response to bladder filling and voiding. Molecular biology of the cell\| PubMed ID: 31166831	2019
The Urothelium: Life in a Liquid Environment. Physiological reviews\| PubMed ID: 32191559	2020
Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception. JCI insight\| PubMed ID: 34464353	2021
Bladder infection with uropathogenic increases the excitability of afferent neurons. American journal of physiology. Renal physiology\| PubMed ID: 34779263	2022
3D printed biaxial stretcher compatible with live fluorescence microscopy. HardwareX\| PubMed ID: 35097243	2020
The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice. JCI insight\| PubMed ID: 35104250	2022
Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRA interstitial cells are fibroblasts. American journal of physiology. Renal physiology\| PubMed ID: 35834272	2022