quantification-atherosclerotic-plaque-activity-vascular-inflammation

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Conventional non-invasive imaging modalities of atherosclerosis such as coronary artery calcium (CAC)1 and carotid intimal medial thickness (C-IMT)2 ...

University of Pennsylvania, Perelman School of Medicine

eQTL &#x89E3;&#x6790;&#x306E;&#x907A;&#x4F1D;&#x76F8;&#x95A2;&#x7D50;&#x679C;&#x306E;&#x7406;&#x89E3;&#x3092;&#x6DF1;&#x3081;&#x308B;&#x3053;&#x3068;&#x304C;&#x91CD;&#x8981;&#x3067;&#x3059;&#x3002;&#x30B2;&#x30CE;&#x30E0;&#x5E83;&#x3044;&#x9023;&#x5408;&#x3068;&#x30B0;&#x30ED;&#x30FC;&#x30D0;&#x30EB;&#x907A;&#x4F1D;&#x5B50;&#x767A;&#x73FE;&#x306E;&#x8ABF;&#x67FB;&#x306E;&#x51A0;&#x52D5;&#x8108;&#x75BE;&#x60A3; &#xFF08;CAD&#xFF09; &#x306E;&#x30EA;&#x30B9;&#x30AF;&#x306B;&#x5F71;&#x97FF;&#x3092;&#x4E0E;&#x3048;&#x308B;&#x6A5F;&#x80FD;&#x7684;&#x95A2;&#x9023;&#x306E;&#x4E9C;&#x7A2E;&#x3092;&#x8B58;&#x5225;&#x3059;&#x308B;&#x3092;&#x5B9F;&#x884C;&#x3057;&#x307E;&#x3059;&#x3002;

&#x30B2;&#x30CE;&#x30E0;&#x5E83;&#x3044;&#x9023;&#x5408;&#x306E;&#x8ABF;&#x67FB;&#x306F;&#x51A0;&#x52D5;&#x8108;&#x75BE;&#x60A3;&#x306E;&#x611F;&#x53D7;&#x6027;&#x907A;&#x4F1D;&#x5B50;&#x3068;&#x3057;&#x3066;&#x30EA;&#x30D1;&#x3092;&#x8B58;&#x5225;&#x3057;&#x307E;&#x3059;&#x3002;

eQTL &#xBD84;&#xC11D;&#xC740; &#xC720;&#xC804; &#xC5F0;&#xACB0; &#xACB0;&#xACFC; &#xC774;&#xD574; &#xD558; &#xACE0; &#xAC1C;&#xC120; &#xD558;&#xB294; &#xAC83;&#xC774; &#xC911;&#xC694; &#xD569;&#xB2C8;&#xB2E4;. &#xC6B0;&#xB9AC;&#xB294; &#xAD00;&#xC0C1; &#xB3D9;&#xB9E5; &#xC9C8;&#xD658; (CAD)&#xC758; &#xC704;&#xD5D8;&#xC5D0; &#xC601;&#xD5A5;&#xC744; &#xBBF8;&#xCE58;&#xB294; &#xAE30;&#xB2A5;&#xC801;&#xC73C;&#xB85C; &#xAD00;&#xB828; &#xB41C; &#xBCC0;&#xC885; &#xC2DD;&#xBCC4; &#xAC8C;&#xB188; &#xB113;&#xC740; &#xD611;&#xD68C; &#xBC0F; &#xAE00;&#xB85C;&#xBC8C; &#xC9C4; &#xC2DD; &#xC5F0;&#xAD6C;&#xB97C; &#xC218;&#xD589;.

&#xAC8C;&#xB188; &#xB113;&#xC740; &#xD611;&#xD68C; &#xC5F0;&#xAD6C; LIPA &#xAD00;&#xC0C1; &#xB3D9;&#xB9E5; &#xC9C8;&#xD658;&#xC5D0; &#xB300; &#xD55C; &#xBBFC;&#xAC10;&#xC131; &#xC720;&#xC804;&#xC790; &#xC2DD;&#xBCC4;&#xD569;&#xB2C8;&#xB2E4;.

An&aacute;lisis de eQTL son importantes para mejorar la comprensi&oacute;n de los resultados de la asociaci&oacute;n gen&eacute;tica. Realizamos una asociaci&oacute;n de genoma y estudio de expresi&oacute;n g&eacute;nica global para identificar variantes funcionalmente relevantes que afectan el riesgo de enfermedad coronaria (CAD).

Un estudio de Asociaci&oacute;n de genoma identifica LIPA como un gen de susceptibilidad para la enfermedad coronaria.

&#x91CD;&#x8981;&#x7684;&#x662F;&#x8981;&#x52A0;&#x6DF1;&#x5BF9;&#x9057;&#x4F20;&#x5173;&#x8054;&#x7ED3;&#x679C;&#x7684; eQTL &#x5206;&#x6790;&#x3002;&#x6211;&#x4EEC;&#x8FDB;&#x884C;&#x4E86;&#x5168;&#x57FA;&#x56E0;&#x7EC4;&#x5173;&#x8054;&#x548C;&#x5168;&#x7403;&#x57FA;&#x56E0;&#x8868;&#x8FBE;&#x7814;&#x7A76;&#xFF0C;&#x4EE5;&#x786E;&#x5B9A;&#x5F71;&#x54CD;&#x98CE;&#x9669;&#x7684;&#x51A0;&#x72B6;&#x52A8;&#x8109;&#x75BE;&#x75C5; (CAD) &#x7684;&#x529F;&#x80FD;&#x4E0A;&#x76F8;&#x5173;&#x53D8;&#x91CF;&#x3002;

&#x5168;&#x57FA;&#x56E0;&#x7EC4;&#x5173;&#x8054;&#x7814;&#x7A76;&#x6807;&#x8BC6;&#x5229;&#x5DF4;&#x4F5C;&#x4E3A;&#x5BF9;&#x51A0;&#x72B6;&#x52A8;&#x8109;&#x75BE;&#x75C5;&#x7684;&#x6613;&#x611F;&#x57FA;&#x56E0;&#x3002;

eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD).

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.

eQTL analyses sont importantes pour am&eacute;liorer la compr&eacute;hension des r&eacute;sultats de l&#39;association g&eacute;n&eacute;tique. Nous avons effectu&eacute; un genome-wide association et &eacute;tude d&#39;expression g&eacute;nique global afin d&#39;identifier les variantes fonctionnellement pertinents affectant le risque de coronaropathie (CP).

Une &eacute;tude G&eacute;nome-large association identifie LIPA comme un g&egrave;ne de susceptibilit&eacute; &agrave; la maladie coronarienne.

eQTL Analysen sind wichtig f&uuml;r die Verbesserung des Verst&auml;ndnisses der genetische Assoziation Ergebnisse. Wir spielten eine genomweiten Association und globale Genausdruckstudie um funktionell relevante Varianten beeinflussen das Risiko einer koronaren Herzkrankheit (KHK) zu identifizieren.

Eine genomweiten Verband-Studie identifiziert LIPA als gen Anf&auml;lligkeit f&uuml;r koronare Herzkrankheit.

eQTL analisi sono importanti per migliorare la comprensione dei risultati di associazione genetica. Abbiamo eseguito un&#39;associazione genome-wide e studio di espressione genica globale per identificare varianti funzionalmente rilevanti che riguardano il rischio di malattia coronarica (CAD).

Article	Year
Circulation\| PubMed ID: 14581389	2003
The Journal of clinical endocrinology and metabolism\| PubMed ID: 17374708	2007
Vascular medicine (London, England)\| PubMed ID: 17451091	2007
Journal of the American College of Cardiology\| PubMed ID: 18617073	2008
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy\| PubMed ID: 18949545	2009
Diabetes\| PubMed ID: 19491209	2009
Diabetes\| PubMed ID: 19581417	2009
Diabetes\| PubMed ID: 19794059	2010
Diabetes care\| PubMed ID: 19910501	2010
European heart journal\| PubMed ID: 20037179	2010
The Journal of investigative dermatology\| PubMed ID: 20231829	2010
International journal of cardiology\| PubMed ID: 20303190	2011
Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20847308	2010
Clinical endocrinology\| PubMed ID: 20874770	2011
The American journal of cardiology\| PubMed ID: 20920650	2010
Diabetes research and clinical practice\| PubMed ID: 21067835	2011
Lancet\| PubMed ID: 21239051	2011
The American journal of cardiology\| PubMed ID: 21257004	2011
The American journal of cardiology\| PubMed ID: 21257006	2011
European heart journal\| PubMed ID: 21415067	2011
The Journal of investigative dermatology\| PubMed ID: 21494241	2011
Diabetes\| PubMed ID: 21525510	2011
Archives of dermatology\| PubMed ID: 21576552	2011
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circulation. Cardiovascular genetics\| PubMed ID: 21606135	2011
Circulation. Cardiovascular genetics\| PubMed ID: 21673312	2011
Cell metabolism\| PubMed ID: 21723499	2011
Hellenic journal of nuclear medicine\| PubMed ID: 21761011	2011
The American journal of medicine\| PubMed ID: 21787906	2011
Circulation. Cardiovascular genetics\| PubMed ID: 21846871	2011
Journal of the American Academy of Dermatology\| PubMed ID: 22018756	2011
The Journal of investigative dermatology\| PubMed ID: 22113483	2012
Trends in cardiovascular medicine\| PubMed ID: 22137643	2010
American journal of cardiovascular disease\| PubMed ID: 22254183	2011
Circulation. Cardiovascular genetics\| PubMed ID: 22337925	2012
Circulation. Cardiovascular genetics\| PubMed ID: 22337928	2012
Journal of the American College of Cardiology\| PubMed ID: 22340269	2012
Atherosclerosis\| PubMed ID: 22456230	2012

Nehal N. Mehta

Biography

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