Brian R. Christie

Division of Medical Sciences, University of Victoria

Affiliated withUniversity of Victoria University of British Columbia

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2023

Other Publications

Article	Year
Long-term depression in vivo: effects of sex, stress, diet, and prenatal ethanol exposure. Hippocampus\| PubMed ID: 18240319	2008
Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus. Neuromolecular medicine\| PubMed ID: 18535925	2008
Stress differentially regulates the effects of voluntary exercise on cell proliferation in the dentate gyrus of mice. Hippocampus\| PubMed ID: 18958850	2009
Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1. Lipids in health and disease\| PubMed ID: 19239689	2009
Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. Hippocampus\| PubMed ID: 19489006	2010
NGF is essential for hippocampal plasticity and learning. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19726646	2009
Running reduces stress and enhances cell genesis in aged mice. Neurobiology of aging\| PubMed ID: 20106549	2011
Characterization of the neurogenesis quiescent zone in the rodent brain: effects of age and exercise. The European journal of neuroscience\| PubMed ID: 20374281	2010
Hippocampal cell loss and neurogenesis after fetal alcohol exposure: insights from different rodent models. Brain research reviews\| PubMed ID: 20471420	2010
Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease. Neurobiology of disease\| PubMed ID: 20875859	2011
Altered adult hippocampal neuronal maturation in a rat model of fetal alcohol syndrome. Brain research\| PubMed ID: 21303667	2011
The role of oxidative stress in fetal alcohol spectrum disorders. Brain research reviews\| PubMed ID: 21315761	2011
Voluntary exercise induces adult hippocampal neurogenesis and BDNF expression in a rodent model of fetal alcohol spectrum disorders. The European journal of neuroscience\| PubMed ID: 21535455	2011
Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult. PloS one\| PubMed ID: 21655192	2011
Neurogenesis in Huntington's disease: can studying adult neurogenesis lead to the development of new therapeutic strategies? Brain research\| PubMed ID: 21742312	2011
Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of voluntary physical exercis... Neuropharmacology\| PubMed ID: 22019722	2012
Omega-3 supplementation can restore glutathione levels and prevent oxidative damage caused by prenatal ethanol exposure. The Journal of nutritional biochemistry\| PubMed ID: 22841392	2013
Enhanced deficits in long-term potentiation in the adult dentate gyrus with 2nd trimester ethanol consumption. PloS one\| PubMed ID: 23227262	2012
Differential response of hippocampal subregions to stress and learning. PloS one\| PubMed ID: 23285257	2012
Omega-3 fatty acids can reverse the long-term deficits in hippocampal synaptic plasticity caused by prenatal ethanol exposure. Neuroscience letters\| PubMed ID: 23872044	2013
Prenatal ethanol (EtOH) exposure alters the sensitivity of the adult dentate gyrus to acute EtOH exposure. Alcoholism, clinical and experimental research\| PubMed ID: 23915337	2014
Impairments in hippocampal synaptic plasticity following prenatal ethanol exposure are dependent on glutathione levels. Hippocampus\| PubMed ID: 23996467	2013
Hippocampal neurogenesis levels predict WATERMAZE search strategies in the aging brain. PloS one\| PubMed ID: 24086453	2013
Long-term exercise is needed to enhance synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 24131795	2013
The role of oxidative stress in Huntington's disease: are antioxidants good therapeutic candidates? Current drug targets\| PubMed ID: 24428525	2014
GluN2A-/- Mice Lack Bidirectional Synaptic Plasticity in the Dentate Gyrus and Perform Poorly on Spatial Pattern Separation Tasks. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 24554729	2015
Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? BioMed research international\| PubMed ID: 24818140	2014
Prenatal ethanol exposure differentially affects hippocampal neurogenesis in the adolescent and aged brain. Neuroscience\| PubMed ID: 24846617	2014
YAC128 Huntington's disease transgenic mice show enhanced short-term hippocampal synaptic plasticity early in the course of the disease. Brain research\| PubMed ID: 24949563	2014
Effects of Ethanol Exposure during Distinct Periods of Brain Development on Hippocampal Synaptic Plasticity. Brain sciences\| PubMed ID: 24961522	2013
Deletion of the NMDA receptor GluN2A subunit significantly decreases dendritic growth in maturing dentate granule neurons. PloS one\| PubMed ID: 25083703	2014
A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors. Frontiers in pediatrics\| PubMed ID: 25232537	2014
Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25331877	2014
Enhanced corticosteroid signaling alters synaptic plasticity in the dentate gyrus in mice lacking the fragile X mental retardation protein. Neurobiology of disease\| PubMed ID: 25731748	2015
Time-Course Analysis of Protein and Lipid Oxidation in the Brains of Yac128 Huntington's Disease Transgenic Mice. Rejuvenation research\| PubMed ID: 26371883	2016
Prenatal ethanol exposure impairs temporal ordering behaviours in young adult rats. Behavioural brain research\| PubMed ID: 26632335	2016
The antidepressant-like effect of chronic guanosine treatment is associated with increased hippocampal neuronal differentiation. The European journal of neuroscience\| PubMed ID: 26779605	2016
Effects of pre-natal alcohol exposure on hippocampal synaptic plasticity: Sex, age and methodological considerations. Neuroscience and biobehavioral reviews\| PubMed ID: 26906760	2016
The effects of hormones and physical exercise on hippocampal structural plasticity. Frontiers in neuroendocrinology\| PubMed ID: 26989000	2016
Chronic minocycline treatment improves social recognition memory in adult male Fmr1 knockout mice. Behavioural brain research\| PubMed ID: 27291517	2016
Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome. Neuroscience and biobehavioral reviews\| PubMed ID: 27345143	2016
ISX-9 can potentiate cell proliferation and neuronal commitment in the rat dentate gyrus. Neuroscience\| PubMed ID: 27373772	2016
Chronic corticosterone administration reduces dendritic complexity in mature, but not young granule cells in the rat dentate gyrus. Restorative neurology and neuroscience\| PubMed ID: 27567758	2016
Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of disease\| PubMed ID: 27659109	2016
The potential for animal models to provide insight into mild traumatic brain injury: Translational challenges and strategies. Neuroscience and biobehavioral reviews\| PubMed ID: 27659125	2017
Mild Traumatic Brain Injury Produces Long-Lasting Deficits in Synaptic Plasticity in the Female Juvenile Hippocampus. Journal of neurotrauma\| PubMed ID: 27735217	2017
The Effects of Ethanol Exposure During Distinct Periods of Brain Development on Oxidative Stress in the Adult Rat Brain. Alcoholism, clinical and experimental research\| PubMed ID: 27862017	2017
Revisiting the flip side: Long-term depression of synaptic efficacy in the hippocampus. Neuroscience and biobehavioral reviews\| PubMed ID: 28624435	2017
Effects of Isx-9 and stress on adult hippocampal neurogenesis: Experimental considerations and future perspectives. Neurogenesis (Austin, Tex.)\| PubMed ID: 28656155	2017
Adolescent ethanol intake alters cannabinoid type-1 receptor localization in astrocytes of the adult mouse hippocampus. Addiction biology\| PubMed ID: 29168269	2019
Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Neurobiology of disease\| PubMed ID: 29367010	2018
Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats. PloS one\| PubMed ID: 29738554	2018
The Benefits of Exercise on Structural and Functional Plasticity in the Rodent Hippocampus of Different Disease Models. Brain plasticity (Amsterdam, Netherlands)\| PubMed ID: 29765836	2015
Impaired spatial processing in a mouse model of fragile X syndrome. Behavioural brain research\| PubMed ID: 29778627	2018
Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury. Annals of clinical and translational neurology\| PubMed ID: 30564624	2018
Effects of Voluntary Exercise on Cell Proliferation and Neurogenesis in the Dentate Gyrus of Adult FMR1 Knockout Mice. Brain plasticity (Amsterdam, Netherlands)\| PubMed ID: 30598869	2018
Fetal alcohol spectrum disorder (FASD) affects the hippocampal levels of histone variant H2A.Z-2. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 30605356	2019
Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells. Frontiers in molecular neuroscience\| PubMed ID: 30705620	2018
Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion. Journal of neurotrauma\| PubMed ID: 30843474	2019
Endocannabinoid long-term depression revealed at medial perforant path excitatory synapses in the dentate gyrus. Neuropharmacology\| PubMed ID: 31022405	2019
Impaired Bidirectional Synaptic Plasticity in Juvenile Offspring Following Prenatal Ethanol Exposure. Alcoholism, clinical and experimental research\| PubMed ID: 31386206	2019
A Rapid Neurological Assessment Protocol for Repeated Mild Traumatic Brain Injury in Awake Rats. Current protocols in neuroscience\| PubMed ID: 31532919	2019
Intermittent ethanol exposure during adolescence impairs cannabinoid type 1 receptor-dependent long-term depression and recognition memory in adult mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 31569197	2020
Modulation of synaptic plasticity by exercise. International review of neurobiology\| PubMed ID: 31607359	2019
Multiple Object Tracking Scores Predict Post-Concussion Status Years after Mild Traumatic Brain Injury. Journal of neurotrauma\| PubMed ID: 31950862	2020
An Engineered Infected Epidermis Model for In Vitro Study of the Skin's Pro-Inflammatory Response. Micromachines\| PubMed ID: 32102205	2020
Hippocampal cognitive impairment in juvenile rats after repeated mild traumatic brain injury. Behavioural brain research\| PubMed ID: 32184155	2020
A Systematic Review of the Effects of Perinatal Alcohol Exposure and Perinatal Marijuana Exposure on Adult Neurogenesis in the Dentate Gyrus. Alcoholism, clinical and experimental research\| PubMed ID: 32246781	2020
Interplay between hormones and exercise on hippocampal plasticity across the lifespan. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 32376385	2020
Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 32817304	2020
Heading in the Right Direction: A Critical Review of Studies Examining the Effects of Heading in Soccer Players. Journal of neurotrauma\| PubMed ID: 32883162	2021
Does Mild Traumatic Brain Injury Increase the Risk for Dementia? A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD\| PubMed ID: 33044182	2020
Unlocking the brain: A new method for Western blot protein detection from fixed brain tissue. Journal of neuroscience methods\| PubMed ID: 33202258	2021
Acute Δ9-tetrahydrocannabinol prompts rapid changes in cannabinoid CB receptor immunolabeling and subcellular structure in CA1 hippocampus of young adult male mice. The Journal of comparative neurology\| PubMed ID: 33368252	2021
Understanding Changes in Hippocampal Interneurons Subtypes in the Pathogenesis of Alzheimer's Disease: A Systematic Review. Brain connectivity\| PubMed ID: 33559520	2021
AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis. International journal of molecular sciences\| PubMed ID: 33669795	2021
Effects of Ethanol on Synaptic Plasticity and NMDA Currents in the Juvenile Rat Dentate Gyrus. Brain plasticity (Amsterdam, Netherlands)\| PubMed ID: 33680851	2020
Chronic AdipoRon Treatment Mimics the Effects of Physical Exercise on Restoring Hippocampal Neuroplasticity in Diabetic Mice. Molecular neurobiology\| PubMed ID: 34164760	2021
Exercise hormone irisin is a critical regulator of cognitive function. Nature metabolism\| PubMed ID: 34417591	2021
Effects of prenatal ethanol exposure on choline-induced long-term depression in the hippocampus. Journal of neurophysiology\| PubMed ID: 34495785	2021
Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus. Alcoholism, clinical and experimental research\| PubMed ID: 34523142	2021
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function. Nature metabolism\| PubMed ID: 34621079	2021
Postnatal Choline Supplementation Rescues Deficits in Synaptic Plasticity Following Prenatal Ethanol Exposure. Nutrients\| PubMed ID: 35631142	2022