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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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JoVE Journal Neuroscience
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

DOI:
10.3791/64592-v

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09:49 min

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January 20, 2023

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, , , , , , , ,
1Division of Medical Sciences,University of Victoria, 2Island Medical Program,University of British Columbia

Chapters

  • 00:04Introduction
  • 01:01Induction of Mild Traumatic Brain Injuries (mTBI)
  • 02:10Slice Preparation
  • 04:09Field Electrophysiology
  • 07:36Results: Effects of Repeated Mild Traumatic Brain Injury (r-mTBI) on Synaptic Plasticity in the Hippocampus
  • 09:02Conclusion

Summary

Automatic Translation

Automatic Translation

Here, it is demonstrated how an awake closed-head injury model can be used for examining the effects of repeated mild traumatic brain injury (r-mTBI) on synaptic plasticity in the hippocampus. The model replicates important features of r-mTBI in patients and is used in conjunction with in vitro electrophysiology.

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Keywords: Synaptic PlasticityAwake Closed-head Injury ModelMild Traumatic Brain Injury (mTBI)Transverse Hippocampal SlicesNeurological Assessment Protocol (NAP)Electrophysiological RecordingsBrain DissectionSlice Preparation

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