Josef Penninger

School of Biomedical Engineering, University of British Columbia

Affiliated withUniversity of British Columbia Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)

Research Area

Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 20	2023

Other Publications

Article	Year
Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Human molecular genetics\| PubMed ID: 15254018	2004
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nature communications\| PubMed ID: 23864022	2013
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24516159	2014
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nature communications\| PubMed ID: 24614889	2014
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell reports\| PubMed ID: 27160902	2016
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nature microbiology\| PubMed ID: 30455472	2019
Human blood vessel organoids as a model of diabetic vasculopathy. Nature\| PubMed ID: 30651639	2019
AIF-regulated oxidative phosphorylation supports lung cancer development. Cell research\| PubMed ID: 31133695	2019
Derivation and maintenance of mouse haploid embryonic stem cells. Nature protocols\| PubMed ID: 31160788	2019
Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31189595	2019
Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. EMBO molecular medicine\| PubMed ID: 31267692	2019
HACE1 deficiency leads to structural and functional neurodevelopmental defects. Neurology. Genetics\| PubMed ID: 31321300	2019
Generation of blood vessel organoids from human pluripotent stem cells. Nature protocols\| PubMed ID: 31554955	2019
Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography. Analytical chemistry\| PubMed ID: 31612716	2019
The Role of Iron Regulation in Immunometabolism and Immune-Related Disease. Frontiers in molecular biosciences\| PubMed ID: 31824960	2019
Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice. Cell death & disease\| PubMed ID: 32001673	2020
A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes. Nature communications\| PubMed ID: 32029734	2020
CLP1 acts as the main RNA kinase in mice. Biochemical and biophysical research communications\| PubMed ID: 32081435	2020
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nature communications\| PubMed ID: 32103002	2020
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive care medicine\| PubMed ID: 32125455	2020
Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2. Biochemical and biophysical research communications\| PubMed ID: 32143824	2020
Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32157739	2020
RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women. Scientific reports\| PubMed ID: 32198488	2020
Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at... Frontiers in bioengineering and biotechnology\| PubMed ID: 32211389	2020
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell\| PubMed ID: 32333836	2020
HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases. Cancer research\| PubMed ID: 32366477	2020
Identification of ALK in Thinness. Cell\| PubMed ID: 32442405	2020
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Communications biology\| PubMed ID: 32620833	2020
Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerging microbes & infections\| PubMed ID: 32691695	2020
Sclerostin expression in trabecular bone is downregulated by osteoclasts. Scientific reports\| PubMed ID: 32792620	2020
Fibroblasts as a source of self-antigens for central immune tolerance. Nature immunology\| PubMed ID: 32839611	2020
Targeting the RANKL/RANK/OPG Axis for Cancer Therapy. Frontiers in oncology\| PubMed ID: 32850393	2020
A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. The Journal of experimental medicine\| PubMed ID: 32930709	2021
Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice. Hepatology (Baltimore, Md.)\| PubMed ID: 32969030	2021
Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 32997739	2021
MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 33098150	2021
The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection. Gastroenterology\| PubMed ID: 33130103	2021
Human recombinant soluble ACE2 in severe COVID-19. The Lancet. Respiratory medicine\| PubMed ID: 33131609	2020
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection. EMBO molecular medicine\| PubMed ID: 33179852	2021
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Science advances\| PubMed ID: 33187978	2021
Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling. The EMBO journal\| PubMed ID: 33215740	2020
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nature metabolism\| PubMed ID: 33288951	2020
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells. Nature communications\| PubMed ID: 33303745	2020
RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature\| PubMed ID: 33361811	2021
Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas. Cancers\| PubMed ID: 33562253	2021
HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner. Oncogene\| PubMed ID: 33603169	2021
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics. Pharmacology & therapeutics\| PubMed ID: 33823204	2021
The oxidoreductase PYROXD1 uses NAD(P) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Molecular cell\| PubMed ID: 33930333	2021
Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends in endocrinology and metabolism: TEM\| PubMed ID: 34006412	2021
A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism. EMBO reports\| PubMed ID: 34121307	2021
Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10. Biochemical and biophysical research communications\| PubMed ID: 34273619	2021
Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites. The EMBO journal\| PubMed ID: 34375000	2021
Autophagy in major human diseases. The EMBO journal\| PubMed ID: 34459017	2021
Development of a novel, pan-variant aerosol intervention for COVID-19. bioRxiv : the preprint server for biology\| PubMed ID: 34545364	2021
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. bioRxiv : the preprint server for biology\| PubMed ID: 34545368	2021
Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 34550333	2021
PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life. Frontiers in molecular neuroscience\| PubMed ID: 34646120	2021
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nature methods\| PubMed ID: 34725484	2021
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains. iScience\| PubMed ID: 34755089	2021
Comparative Proteome Signatures of Trace Samples by Multiplexed Data-Independent Acquisition. Molecular & cellular proteomics : MCP\| PubMed ID: 34793982	2022
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nature communications\| PubMed ID: 34815389	2021
Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nature methods\| PubMed ID: 34893784	2022
Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor. eLife\| PubMed ID: 34927585	2021
Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19. Frontiers in immunology\| PubMed ID: 35003058	2021
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology. eLife\| PubMed ID: 35023830	2022
Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function. The FEBS journal\| PubMed ID: 35029322	2022
TSPAN6 is a suppressor of Ras-driven cancer. Oncogene\| PubMed ID: 35184157	2022
Correction: TSPAN6 is a suppressor of Ras-driven cancer. Oncogene\| PubMed ID: 35292775	2022
Adult T-cells impair neonatal cardiac regeneration. European heart journal\| PubMed ID: 35417553	2022
Recalibrating vascular malformations and mechanotransduction by pharmacological intervention. The Journal of clinical investigation\| PubMed ID: 35426368	2022
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. Cell metabolism\| PubMed ID: 35561674	2022
Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. Cell\| PubMed ID: 35623327	2022
Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study. Pathogens (Basel, Switzerland)\| PubMed ID: 35631123	2022
Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells. Cellular and molecular life sciences : CMLS\| PubMed ID: 35661927	2022
Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide. Scientific reports\| PubMed ID: 35672347	2022
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. EMBO molecular medicine\| PubMed ID: 35781796	2022
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer. PloS one\| PubMed ID: 35816490	2022
Targeting glycans for CAR therapy: The advent of sweet CARs. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 35821636	2022
ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury. PloS one\| PubMed ID: 35867642	2022
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO molecular medicine\| PubMed ID: 35916241	2022
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. American journal of respiratory and critical care medicine\| PubMed ID: 35926164	2023
AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury. Molecular neurobiology\| PubMed ID: 35974295	2022
The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers. Frontiers in molecular neuroscience\| PubMed ID: 36187350	2022
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo. Cell reports. Medicine\| PubMed ID: 36195094	2022
On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for v... Clinical and translational medicine\| PubMed ID: 36229914	2022
The HUSH complex controls brain architecture and protocadherin fidelity. Science advances\| PubMed ID: 36332029	2022
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. Nature communications\| PubMed ID: 36443325	2022
RANKL and RANK in Cancer Therapy. Physiology (Bethesda, Md.)\| PubMed ID: 36473204	2022
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications\| PubMed ID: 36566234	2022
Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells. STAR protocols\| PubMed ID: 36595951	2022
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation. Cell & bioscience\| PubMed ID: 36624495	2023