Tetsuo Nagano

Graduate School of Pharmaceutical Sciences, University of Tokyo

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2012

Other Publications

Article	Year
Orthogonality of calcium concentration and ability of 4,5-diaminofluorescein to detect NO. The Journal of biological chemistry\| PubMed ID: 11641405	2002
Activation mechanism of Gi and Go by reactive oxygen species. The Journal of biological chemistry\| PubMed ID: 11781308	2002
Design and synthesis of an enzyme-cleavable sensor molecule for phosphodiesterase activity based on fluorescence resonance energy transfer. Journal of the American Chemical Society\| PubMed ID: 11853439	2002
Impurity profiling of ephedrines in methamphetamine by high-performance liquid chromatography. Journal of chromatography. A\| PubMed ID: 11873994	2002
Bioimaging of nitric oxide. Chemical reviews\| PubMed ID: 11942795	2002
A fluorescent anion sensor that works in neutral aqueous solution for bioanalytical application. Journal of the American Chemical Society\| PubMed ID: 11942829	2002
Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding. Bioorganic & medicinal chemistry letters\| PubMed ID: 11958992	2002
Improvement and biological applications of fluorescent probes for zinc, ZnAFs. Journal of the American Chemical Society\| PubMed ID: 12047174	2002
Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits. The Journal of cell biology\| PubMed ID: 12119362	2002
Multiple active intermediates in oxidation reaction catalyzed by synthetic heme-thiolate complex relevant to cytochrome p450. Journal of the American Chemical Society\| PubMed ID: 12167058	2002
A novel, cell-permeable, fluorescent probe for ratiometric imaging of zinc ion. Journal of the American Chemical Society\| PubMed ID: 12207508	2002
Design and synthesis of a novel magnetic resonance imaging contrast agent for selective sensing of zinc ion. Chemistry & biology\| PubMed ID: 12323377	2002
Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. The Journal of biological chemistry\| PubMed ID: 12419811	2003
Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy. Bioconjugate chemistry\| PubMed ID: 12526693	2003
Nitric oxide (NO) synthase mRNA expression and NO production via muscarinic acetylcholine receptor-mediated pathways in the CEM, human leukemic T-cell line. Life sciences\| PubMed ID: 12628472	2003
A novel design method of ratiometric fluorescent probes based on fluorescence resonance energy transfer switching by spectral overlap integral. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 12658644	2003
Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. The European journal of neuroscience\| PubMed ID: 12713641	2003
[Statistics on operations at the Department of Urology, Nippon Telegraph and Telephone West Osaka Hospital during a ten-year period from 1992 to 2001]. Hinyokika kiyo. Acta urologica Japonica\| PubMed ID: 12728535	2003
Production of singlet oxygen on irradiation of a photodynamic therapy agent, zinc-coproporphyrin III, with low host toxicity. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine\| PubMed ID: 12779244	2003
Spatiotemporal laser inactivation of inositol 1,4,5-trisphosphate receptors using synthetic small-molecule probes. Chemistry & biology\| PubMed ID: 12837383	2003
Rational design principle for modulating fluorescence properties of fluorescein-based probes by photoinduced electron transfer. Journal of the American Chemical Society\| PubMed ID: 12848574	2003
Selective detection of zinc ions with novel luminescent lanthanide probes. Angewandte Chemie (International ed. in English)\| PubMed ID: 12851952	2003
Development of selective, visible light-excitable, fluorescent magnesium ion probes with a novel fluorescence switching mechanism. The Analyst\| PubMed ID: 12866894	2003
Characterization of N-methyl-D-aspartate receptor subunits involved in acute ammonia toxicity. Neurochemistry international\| PubMed ID: 12971910	2004
Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2. Journal of the American Chemical Society\| PubMed ID: 14558828	2003
Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe. Journal of the American Chemical Society\| PubMed ID: 15012166	2004
Zinc sensing for cellular application. Current opinion in chemical biology\| PubMed ID: 15062780	2004
Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in a human pancreatic cancer cell line, KP4. Antioxidants & redox signaling\| PubMed ID: 15130279	2004
A novel fluorescent probe for zinc ion based on boron dipyrromethene (BODIPY) chromophore. Chemical & pharmaceutical bulletin\| PubMed ID: 15187390	2004
Determination of origin of ephedrine used as precursor for illicit methamphetamine by carbon and nitrogen stable isotope ratio analysis. Analytical chemistry\| PubMed ID: 15253668	2004
AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation\| PubMed ID: 15262850	2004
Modification of intracellular Ca2+ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes. Chemistry & biology\| PubMed ID: 15324806	2004
[Fluorescence spectroscopy]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 15377003	2004
Development of a zinc ion-selective luminescent lanthanide chemosensor for biological applications. Journal of the American Chemical Society\| PubMed ID: 15453781	2004
Rational principles for modulating fluorescence properties of fluorescein. Journal of the American Chemical Society\| PubMed ID: 15506772	2004
Design and synthesis of zinc-selective chelators for extracellular applications. Journal of the American Chemical Society\| PubMed ID: 15656603	2005
Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency. Epilepsy research\| PubMed ID: 15716032	2005
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. The Journal of biological chemistry\| PubMed ID: 15769751	2005
Highly sensitive near-infrared fluorescent probes for nitric oxide and their application to isolated organs. Journal of the American Chemical Society\| PubMed ID: 15771488	2005
Evolution of fluorescein as a platform for finely tunable fluorescence probes. Journal of the American Chemical Society\| PubMed ID: 15796553	2005
Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices. Journal of the American Chemical Society\| PubMed ID: 16028930	2005
Extension of the applicable range of fluorescein: a fluorescein-based probe for Western blot analysis. Angewandte Chemie (International ed. in English)\| PubMed ID: 16044483	2005
[Analysis of intracellular membrane protein function by small molecule-based chromophore-assisted laser inactivation]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 16104611	2005
Highly efficient and photostable photosensitizer based on BODIPY chromophore. Journal of the American Chemical Society\| PubMed ID: 16131160	2005
The detection and quantification of highly reactive oxygen species using the novel HPF fluorescence probe in a rat model of focal cerebral ischemia. Neuroscience research\| PubMed ID: 16168507	2005
Evidence for pH dependent Zn2+influx in K562 erythroleukemia cells: studies using ZnAF-2F fluorescence and 65Zn2+ uptake. Archives of biochemistry and biophysics\| PubMed ID: 16183033	2005
Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation. Journal of neuroscience research\| PubMed ID: 16342122	2006
Development of a ratiometric fluorescent zinc ion probe in near-infrared region, based on tricarbocyanine chromophore. Journal of the American Chemical Society\| PubMed ID: 16704241	2006
Modulation of luminescence intensity of lanthanide complexes by photoinduced electron transfer and its application to a long-lived protease probe. Journal of the American Chemical Society\| PubMed ID: 16719474	2006
Charge separation in a nonfluorescent donor-acceptor dyad derived from boron dipyrromethene dye, leading to photocurrent generation. The journal of physical chemistry. B\| PubMed ID: 16852949	2005
Fluorescence-based zinc ion sensor for zinc ion release from pancreatic cells. Analytical chemistry\| PubMed ID: 16906726	2006
Mechanism-based molecular design of highly selective fluorescence probes for nitrative stress. Journal of the American Chemical Society\| PubMed ID: 16910633	2006
Tunable design strategy for fluorescence probes based on 4-substituted BODIPY chromophore: improvement of highly sensitive fluorescence probe for nitric oxide. Analytical and bioanalytical chemistry\| PubMed ID: 16924384	2006
[Development and biological applications of various bioimaging probes]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan\| PubMed ID: 17016020	2006
Design and synthesis of an enzyme activity-based labeling molecule with fluorescence spectral change. Journal of the American Chemical Society\| PubMed ID: 17165702	2006
Creation of superior carboxyfluorescein dyes by blocking donor-excited photoinduced electron transfer. Organic letters\| PubMed ID: 17165905	2006
[How to develop custom-designed fluorescence probes for molecular imaging]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 17302268	2007
Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging. Colloids and surfaces. B, Biointerfaces\| PubMed ID: 17324561	2007
An enzymatically activated fluorescence probe for targeted tumor imaging. Journal of the American Chemical Society\| PubMed ID: 17352471	2007
Design and synthesis of a library of BODIPY-based environmental polarity sensors utilizing photoinduced electron-transfer-controlled fluorescence ON/OFF switching. Journal of the American Chemical Society\| PubMed ID: 17425310	2007
Highly activatable and rapidly releasable caged fluorescein derivatives. Journal of the American Chemical Society\| PubMed ID: 17474746	2007
Development of a highly specific rhodamine-based fluorescence probe for hypochlorous acid and its application to real-time imaging of phagocytosis. Journal of the American Chemical Society\| PubMed ID: 17506554	2007
A thiol-reactive fluorescence probe based on donor-excited photoinduced electron transfer: key role of ortho substitution. Organic letters\| PubMed ID: 17645349	2007
Design and synthesis of fluorescent probes for selective detection of highly reactive oxygen species in mitochondria of living cells. Journal of the American Chemical Society\| PubMed ID: 17672465	2007
Site-specific oxidative stress induction. Chemistry & biology\| PubMed ID: 17719486	2007
Development of an iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc. Journal of the American Chemical Society\| PubMed ID: 17927174	2007
Time-resolved long-lived luminescence imaging method employing luminescent lanthanide probes with a new microscopy system. Journal of the American Chemical Society\| PubMed ID: 17927176	2007
A Gd3+-based magnetic resonance imaging contrast agent sensitive to beta-galactosidase activity utilizing a receptor-induced magnetization enhancement (RIME) phenomenon. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 17992679	2008
[Chemical biology: overview]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 18051372	2007
[Development of fluorescent probes for nitric oxide]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 18051375	2007
[Mechanism-based molecular design of highly selective peroxynitrite probe]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 18051376	2007
[In-vivo cancer fluorescence imaging with novel precisely-designed fluorescence probes]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 18051385	2007
Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18172220	2008
Evaluation of characteristic deuterium distributions of ephedrines and methamphetamines by NMR spectroscopy for drug profiling. Analytical chemistry\| PubMed ID: 18271510	2008
Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18441197	2008
Calcineurin is critical for sodium-induced neointimal formation in normotensive and hypertensive rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18456738	2008
Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 18524589	2008
[Cellular imaging by using molecular probes]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica\| PubMed ID: 18622096	2008
Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese Zucker rats. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 18633186	2008
Fluorescent probes for bioimaging applications. Current opinion in chemical biology\| PubMed ID: 18771748	2008
Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells. Journal of the American Chemical Society\| PubMed ID: 18841967	2008
Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nature medicine\| PubMed ID: 19029979	2009
A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 19262472	2009
Design and development of enzymatically activatable photosensitizer based on unique characteristics of thiazole orange. Journal of the American Chemical Society\| PubMed ID: 19364098	2009
Use of stable isotope ratios for profiling of industrial ephedrine samples: application of hydrogen isotope ratios in combination with carbon and nitrogen. Forensic science international\| PubMed ID: 19428199	2009
Anion sensor-based ratiometric peptide probe for protein kinase activity. Organic letters\| PubMed ID: 19552460	2009
A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells. Journal of the American Chemical Society\| PubMed ID: 19572714	2009
Molecular design strategies for near-infrared ratiometric fluorescent probes based on the unique spectral properties of aminocyanines. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19650089	2009
Fluorescence imaging of tumors with "smart" pH-activatable targeted probes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19685299	2009
Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen. Biological & pharmaceutical bulletin\| PubMed ID: 19721223	2009
Bioimaging probes for reactive oxygen species and reactive nitrogen species. Journal of clinical biochemistry and nutrition\| PubMed ID: 19794917	2009
Development of 2,6-carboxy-substituted boron dipyrromethene (BODIPY) as a novel scaffold of ratiometric fluorescent probes for live cell imaging. Chemical communications (Cambridge, England)\| PubMed ID: 19904379	2009
Design and synthesis of a highly sensitive off-on fluorescent chemosensor for zinc ions utilizing internal charge transfer. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19918808	2010
Adipose tissue-derived stem cells inhibit neointimal formation in a paracrine fashion in rat femoral artery. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19940081	2010
Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes. Journal of the American Chemical Society\| PubMed ID: 20136129	2010
Sensitive detection of acrolein in serum using time-resolved luminescence. Organic letters\| PubMed ID: 20232900	2010
A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein-peptide interaction inhibitors. Analytical biochemistry\| PubMed ID: 20298671	2010
Establishment of an indicator cell system for hepatitis C virus. Microbiology and immunology\| PubMed ID: 20377749	2010
Development of enzyme-activated photosensitizer based on intramolecular electron transfer. Bioorganic & medicinal chemistry letters\| PubMed ID: 20615703	2010
Design and synthesis of a novel fluorescence probe for Zn2+ based on the spirolactam ring-opening process of rhodamine derivatives. Bioorganic & medicinal chemistry\| PubMed ID: 20620067	2011
Development of luciferin analogues bearing an amino group and their application as BRET donors. Chemistry, an Asian journal\| PubMed ID: 20661993	2010
A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 20938933	2010
Development of fluorescent probes for bioimaging applications. Proceedings of the Japan Academy. Series B, Physical and biological sciences\| PubMed ID: 20948177	2010
Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia. Journal of the American Chemical Society\| PubMed ID: 20979363	2010
[Integration research of structural biology and chemical biology focused on drug discovery]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme\| PubMed ID: 21089565	2009
Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice. Pharmaceutical research\| PubMed ID: 21116691	2011
Identification of novel ASK1 inhibitors using virtual screening. Bioorganic & medicinal chemistry\| PubMed ID: 21134755	2011
A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. Journal of the American Chemical Society\| PubMed ID: 21142151	2011
Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. Journal of virology\| PubMed ID: 21177810	2011
A dual inhibitor against prolyl isomerase Pin1 and cyclophilin discovered by a novel real-time fluorescence detection method. Biochemical and biophysical research communications\| PubMed ID: 21333629	2011
Rational design of ratiometric near-infrared fluorescent pH probes with various pKa values, based on aminocyanine. Journal of the American Chemical Society\| PubMed ID: 21341656	2011
Development of a fluorescein analogue, TokyoMagenta, as a novel scaffold for fluorescence probes in red region. Chemical communications (Cambridge, England)\| PubMed ID: 21359330	2011
In situ evaluation of kinetic resolution catalysts for nitroaldol by rationally designed fluorescence probe. The Journal of organic chemistry\| PubMed ID: 21370849	2011
Evolution of group 14 rhodamines as platforms for near-infrared fluorescence probes utilizing photoinduced electron transfer. ACS chemical biology\| PubMed ID: 21375253	2011
Aminoluciferins as functional bioluminogenic substrates of firefly luciferase. Chemistry, an Asian journal\| PubMed ID: 21416616	2011
Development of an Si-rhodamine-based far-red to near-infrared fluorescence probe selective for hypochlorous acid and its applications for biological imaging. Journal of the American Chemical Society\| PubMed ID: 21443186	2011
Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling method. Journal of the American Chemical Society\| PubMed ID: 21473619	2011
Development of a highly selective fluorescence probe for alkaline phosphatase. Bioorganic & medicinal chemistry letters\| PubMed ID: 21482108	2011
Virtual screening and further development of novel ALK inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 21515061	2011
Development of a highly sensitive fluorescence probe for hydrogen peroxide. Journal of the American Chemical Society\| PubMed ID: 21692459	2011
Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor. Journal of the American Chemical Society\| PubMed ID: 21721554	2011
Î²-Galactosidase fluorescence probe with improved cellular accumulation based on a spirocyclized rhodol scaffold. Journal of the American Chemical Society\| PubMed ID: 21786797	2011
Fluorescent probes for sensing and imaging. Nature methods\| PubMed ID: 21799499	2011
Rational design of boron dipyrromethene (BODIPY)-based photobleaching-resistant fluorophores applicable to a protein dynamics study. Chemical communications (Cambridge, England)\| PubMed ID: 21818482	2011
Development of a far-red to near-infrared fluorescence probe for calcium ion and its application to multicolor neuronal imaging. Journal of the American Chemical Society\| PubMed ID: 21827169	2011
Development of a potassium ion-selective fluorescent sensor based on 3-styrylated BODIPY. Bioorganic & medicinal chemistry letters\| PubMed ID: 21906942	2011
Method for enhancing cell penetration of Gd3+-based MRI contrast agents by conjugation with hydrophobic fluorescent dyes. Bioconjugate chemistry\| PubMed ID: 21985057	2011
Development of a highly selective fluorescence probe for hydrogen sulfide. Journal of the American Chemical Society\| PubMed ID: 21999237	2011
Activatable optical imaging with a silica-rhodamine based near infrared (SiR700) fluorophore: a comparison with cyanine based dyes. Bioconjugate chemistry\| PubMed ID: 22034863	2011
Rational development of caged-biotin protein-labeling agents and some applications in live cells. Chemistry & biology\| PubMed ID: 22035795	2011
Selective two-step labeling of proteins with an off/on fluorescent probe. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22106092	2011
Rapid cancer detection by topically spraying a Î³-glutamyltranspeptidase-activated fluorescent probe. Science translational medicine\| PubMed ID: 22116934	2011
Visible-light-triggered release of nitric oxide from N-pyramidal nitrosamines. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 22179925	2012
A practical strategy to create near-infrared luminescent probes: conversion from fluorescein-based sensors. Chemical communications (Cambridge, England)\| PubMed ID: 22222313	2012
A long-lived luminescent probe to sensitively detect arylamine N-acetyltransferase (NAT) activity of cells. Chemical communications (Cambridge, England)\| PubMed ID: 22252439	2012
A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide. Journal of molecular biology\| PubMed ID: 22306408	2012
Myeloperoxidase Exacerbates Secondary Injury by Generating Highly Reactive Oxygen Species and Mediating Neutrophil Recruitment in Experimental Spinal Cord Injury. Spine\| PubMed ID: 22322369	2012
A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine. Chemical communications (Cambridge, England)\| PubMed ID: 22344329	2012
Development of NIR Fluorescent Dyes Based on Si-rhodamine for in Vivo Imaging. Journal of the American Chemical Society\| PubMed ID: 22390359	2012