David L. Spector

Cold Spring Harbor Laboratory, Cold Spring Harbor

Affiliated withCold Spring Harbor Stony Brook University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2023

Other Publications

Article	Year
The dynamic organization of the perinucleolar compartment in the cell nucleus. The Journal of cell biology\| PubMed ID: 9166399	1997
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. The Journal of cell biology\| PubMed ID: 9230067	1997
Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies. Molecular biology of the cell\| PubMed ID: 9571236	1998
The perinucleolar compartment and transcription. The Journal of cell biology\| PubMed ID: 9763419	1998
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. The Journal of cell biology\| PubMed ID: 9786943	1998
Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides. Nucleic acids research\| PubMed ID: 10606658	2000
Quantitative imaging of pre-mRNA splicing factors in living cells. Molecular biology of the cell\| PubMed ID: 10679003	2000
Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus. Nature cell biology\| PubMed ID: 11753375	2002
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing. The Journal of cell biology\| PubMed ID: 11827980	2002
A molecular dissection of nuclear function. Conference on the dynamic nucleus: questions and implications. EMBO reports\| PubMed ID: 12524514	2003
Sequential entry of components of the gene expression machinery into daughter nuclei. Molecular biology of the cell\| PubMed ID: 12631722	2003
Nuclear choreography: interpretations from living cells. Current opinion in cell biology\| PubMed ID: 12648670	2003
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell\| PubMed ID: 12809602	2003
The dynamics of chromosome organization and gene regulation. Annual review of biochemistry\| PubMed ID: 14527325	2003
From silencing to gene expression: real-time analysis in single cells. Cell\| PubMed ID: 15006351	2004
Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis. Molecular biology of the cell\| PubMed ID: 15034145	2004
"On the move"ments of nuclear components in living cells. Experimental cell research\| PubMed ID: 15120987	2004
Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. Molecular biology of the cell\| PubMed ID: 15146063	2004
Proteomic analysis of interchromatin granule clusters. Molecular biology of the cell\| PubMed ID: 15169873	2004
Dynamics of single mRNPs in nuclei of living cells. Science (New York, N.Y.)\| PubMed ID: 15205532	2004
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. The EMBO journal\| PubMed ID: 15215892	2004
Stopping for FISH and chips along the chromatin fiber superhighway. Molecular cell\| PubMed ID: 15383273	2004
Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei. The Journal of cell biology\| PubMed ID: 15479736	2004
Centromere positioning and dynamics in living Arabidopsis plants. Molecular biology of the cell\| PubMed ID: 16195344	2005
Regulating gene expression through RNA nuclear retention. Cell\| PubMed ID: 16239143	2005
Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm. Molecular biology of the cell\| PubMed ID: 16371503	2006
Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats. PLoS genetics\| PubMed ID: 16389298	2005
PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. Genes & development\| PubMed ID: 16600910	2006
SnapShot: Cellular bodies. Cell\| PubMed ID: 17129789	2006
Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum. Genes & development\| PubMed ID: 17210785	2007
Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants. Current biology : CB\| PubMed ID: 17442570	2007
A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence. The Journal of cell biology\| PubMed ID: 18195101	2008
Chromatin dynamics and gene positioning. Cell\| PubMed ID: 18358806	2008
Live cell dynamics of promyelocytic leukemia nuclear bodies upon entry into and exit from mitosis. Molecular biology of the cell\| PubMed ID: 18480407	2008
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature\| PubMed ID: 18931659	2008
3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell\| PubMed ID: 19041754	2008
MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome research\| PubMed ID: 19106332	2009
Nuclear neighborhoods and gene expression. Current opinion in genetics & development\| PubMed ID: 19339170	2009
Long noncoding RNAs: functional surprises from the RNA world. Genes & development\| PubMed ID: 19571179	2009
An unexpected ending: noncanonical 3' end processing mechanisms. RNA (New York, N.Y.)\| PubMed ID: 20007330	2010
The life of an mRNA in space and time. Journal of cell science\| PubMed ID: 20427315	2010
Chromatin dynamics. Annual review of biophysics\| PubMed ID: 20462379	2010
A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. The EMBO journal\| PubMed ID: 20729808	2010
Nonrigid registration of 2-D and 3-D dynamic cell nuclei images for improved classification of subcellular particle motion. IEEE transactions on image processing : a publication of the IEEE Signal Processing Society\| PubMed ID: 20840894	2011
Nuclear organization and dynamics of 7SK RNA in regulating gene expression. Molecular biology of the cell\| PubMed ID: 20881057	2010
Nuclear speckles. Cold Spring Harbor perspectives in biology\| PubMed ID: 20926517	2011
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Molecular cell\| PubMed ID: 21035370	2010
Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs. Nature cell biology\| PubMed ID: 21170033	2011
Four amino acids guide the assembly or disassembly of Arabidopsis histone H3.3-containing nucleosomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21670303	2011
Biogenesis and function of nuclear bodies. Trends in genetics : TIG\| PubMed ID: 21680045	2011
Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nature cell biology\| PubMed ID: 21983563	2011
The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell reports\| PubMed ID: 22840402	2012
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer research\| PubMed ID: 23243023	2013
Chromatin organization and transcriptional regulation. Current opinion in genetics & development\| PubMed ID: 23270812	2013
Lamin A/C is expressed in pluripotent mouse embryonic stem cells. Nucleus (Austin, Tex.)\| PubMed ID: 23324457	2013
Chromatin meets its organizers. Cell\| PubMed ID: 23746835	2013
Receptor-mediated delivery of engineered nucleases for genome modification. Nucleic acids research\| PubMed ID: 23956220	2013
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes & development\| PubMed ID: 24285714	2013
Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements. Stem cell reports\| PubMed ID: 24286025	2013
Long non-coding RNAs: modulators of nuclear structure and function. Current opinion in cell biology\| PubMed ID: 24529241	2014
Random monoallelic gene expression increases upon embryonic stem cell differentiation. Developmental cell\| PubMed ID: 24576421	2014
Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24578380	2014
Random monoallelic expression: regulating gene expression one allele at a time. Trends in genetics : TIG\| PubMed ID: 24780084	2014
Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data. Medical image analysis\| PubMed ID: 25181702	2015
Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation. Cell stem cell\| PubMed ID: 25748933	2015
Regulation of the ESC transcriptome by nuclear long noncoding RNAs. Genome research\| PubMed ID: 26048247	2015
Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2. BMC genomics\| PubMed ID: 26589460	2015
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes & development\| PubMed ID: 26701265	2016
Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration. Cell reports\| PubMed ID: 27681436	2016
Identification and Characterization of a Class of MALAT1-like Genomic Loci. Cell reports\| PubMed ID: 28538188	2017
A lncRNA fine tunes the dynamics of a cell state transition involving , and DNA methylation. eLife\| PubMed ID: 28820723	2017
Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids. Bio-protocol\| PubMed ID: 28932764	2017
Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends in molecular medicine\| PubMed ID: 29449148	2018
POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes & development\| PubMed ID: 29945888	2018
MALAT1 long non-coding RNA and breast cancer. RNA biology\| PubMed ID: 30874469	2019
Long Non-Coding RNA: Functional Implications. Non-coding RNA\| PubMed ID: 32503170	2020
Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing. Genome research\| PubMed ID: 32887686	2020
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression. Nature communications\| PubMed ID: 33353933	2020
: a long non-coding RNA involved in breast cancer progression. Molecular & cellular oncology\| PubMed ID: 33860086	2021
lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR. eLife\| PubMed ID: 34002693	2021
Activating a collaborative innate-adaptive immune response to control metastasis. Cancer cell\| PubMed ID: 34478639	2021
Noncoding RNAs: biology and applications-a Keystone Symposia report. Annals of the New York Academy of Sciences\| PubMed ID: 34791665	2021
Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics. Cancer research\| PubMed ID: 35180770	2022
Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage. Nature communications\| PubMed ID: 36216821	2022
Simultaneous visualization of RNA transcripts and proteins in whole-mount mouse preimplantation embryos using single-molecule fluorescence hybridization and immunofluorescence microscopy. Frontiers in cell and developmental biology\| PubMed ID: 36268512	2022
Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Developmental cell\| PubMed ID: 36347239	2022
Testing for Phylogenetic Signal in Single-Cell RNA-Seq Data. Journal of computational biology : a journal of computational molecular cell biology\| PubMed ID: 36475926	2022
Single Oligonucleotide Capture of RNA And Temperature Elution Series ( ) for Identification of RNA-binding Proteins. Bio-protocol\| PubMed ID: 36618090	2022