Adam C. Resnick

Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia

Affiliated withChildren’s Hospital of Philadelphia

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2023

Other Publications

Article	Year
Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17981594	2008
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18268345	2008
Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain pathology (Zurich, Switzerland)\| PubMed ID: 19016743	2009
Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro-oncology\| PubMed ID: 20156809	2010
The genetic landscape of the childhood cancer medulloblastoma. Science (New York, N.Y.)\| PubMed ID: 21163964	2011
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21220345	2011
Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. Journal of neurosurgery. Pediatrics\| PubMed ID: 22656257	2012
Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23533272	2013
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nature genetics\| PubMed ID: 24413733	2014
Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro-oncology\| PubMed ID: 24803676	2014
A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5). The Journal of biological chemistry\| PubMed ID: 26828065	2016
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nature genetics\| PubMed ID: 26829751	2016
BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 27217440	2016
The biorepository portal toolkit: an honest brokered, modular service oriented software tool set for biospecimen-driven translational research. BMC genomics\| PubMed ID: 27535360	2016
Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27791083	2016
MYB-QKI drives childhood brain tumors via tripartite mechanism. Cell cycle (Georgetown, Tex.)\| PubMed ID: 27973981	2017
Shared ACVR1 mutations in FOP and DIPG: Opportunities and challenges in extending biological and clinical implications across rare diseases. Bone\| PubMed ID: 28780023	2018
Overcoming resistance to single-agent therapy for oncogenic gene fusions combinatorial targeting of MAPK and PI3K/mTOR signaling pathways. Oncotarget\| PubMed ID: 29156677	2017
The landscape of genomic alterations across childhood cancers. Nature\| PubMed ID: 29489754	2018
Plain-language medical vocabulary for precision diagnosis. Nature genetics\| PubMed ID: 29632381	2018
Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. Cancer research\| PubMed ID: 29760046	2018
Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. Cancer cell\| PubMed ID: 29763623	2018
Novel FGFR2-INA fusion identified in two low-grade mixed neuronal-glial tumors drives oncogenesis via MAPK and PI3K/mTOR pathway activation. Acta neuropathologica\| PubMed ID: 29767381	2018
Author Correction: The landscape of genomic alterations across childhood cancers. Nature\| PubMed ID: 29875405	2018
Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response. Human gene therapy\| PubMed ID: 30024272	2019
Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30322880	2018
IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration. Cell reports\| PubMed ID: 30840891	2019
A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium. International journal of cancer\| PubMed ID: 30861105	2019
Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma. Cancer research\| PubMed ID: 30877103	2019
Transcriptome signatures associated with meningioma progression. Acta neuropathologica communications\| PubMed ID: 31039818	2019
Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers. The Journal of molecular diagnostics : JMD\| PubMed ID: 31255796	2019
Immunotherapy for pediatric brain tumors: past and present. Neuro-oncology\| PubMed ID: 31504801	2019
Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways. Journal of neuropathology and experimental neurology\| PubMed ID: 31617914	2019
Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer. JAMA network open\| PubMed ID: 31651965	2019
The InsP phosphatase Siw14 regulates inositol pyrophosphate levels to control localization of the general stress response transcription factor Msn2. The Journal of biological chemistry\| PubMed ID: 31848224	2020
Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer. BMC medical genetics\| PubMed ID: 32375678	2020
A germline pathogenic variant identified in a pediatric high-grade glioma. Cold Spring Harbor molecular case studies\| PubMed ID: 32554798	2020
Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas. Scientific reports\| PubMed ID: 32616776	2020
A transcriptome-based classifier to determine molecular subtypes in medulloblastoma. PLoS computational biology\| PubMed ID: 33119584	2020
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer. Cell\| PubMed ID: 33242424	2020
annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions. BMC bioinformatics\| PubMed ID: 33317447	2020
Genomic characterization of a PPP1CB-ALK fusion with fusion gene amplification in a congenital glioblastoma. Cancer genetics\| PubMed ID: 33341678	2021
BRAF fusions in pediatric histiocytic neoplasms define distinct therapeutic responsiveness to RAF paradox breakers. Pediatric blood & cancer\| PubMed ID: 33565241	2021
Proteogenomic and metabolomic characterization of human glioblastoma. Cancer cell\| PubMed ID: 33577785	2021
Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1). Acta neuropathologica\| PubMed ID: 33585982	2021
NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome. JCO precision oncology\| PubMed ID: 34036219	2021
Cancer Informatics for Cancer Centers: Scientific Drivers for Informatics, Data Science, and Care in Pediatric, Adolescent, and Young Adult Cancer. JCO clinical cancer informatics\| PubMed ID: 34428097	2021
Targeted gene expression profiling of inverted papilloma and squamous cell carcinoma. International forum of allergy & rhinology\| PubMed ID: 34510780	2022
MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data. PLoS computational biology\| PubMed ID: 34762648	2021
Neurotrophic tyrosine receptor kinase fusion in pediatric central nervous system tumors. Cancer genetics\| PubMed ID: 35108662	2022
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. Journal for immunotherapy of cancer\| PubMed ID: 36167467	2022
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science. Neoplasia (New York, N.Y.)\| PubMed ID: 36335802	2023
ALT in Pediatric High-Grade Gliomas Can Occur without ATRX Mutation and is Enriched in Patients with Pathogenic Germline MMR Variants. Neuro-oncology\| PubMed ID: 36541551	2022