Howard Y. Chang

Howard Y. Chang

Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine

Affiliated withStanford University School of Medicine

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1
Year
Chromatin Isolation by RNA Purification (ChIRP)
Publication title

Cited by 377

2012

Other Publications

Article
Year
Diversity, topographic differentiation, and positional memory in human fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 12297622

2002
Knowledge, attitudes, and practice styles of North American pediatric gastroenterologists: Helicobacter pylori infection.

Journal of pediatric gastroenterology and nutrition| PubMed ID: 12548060

2003
HOTAIR: Flight of noncoding RNAs in cancer metastasis.

Cell cycle (Georgetown, Tex.)| PubMed ID: 20864820

2010
Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut.

American journal of physiology. Gastrointestinal and liver physiology| PubMed ID: 12576302

2003
Genomewide view of gene silencing by small interfering RNAs.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 12730368

2003
Myelogenous leukemia cutis resembling stasis dermatitis.

Journal of the American Academy of Dermatology| PubMed ID: 12833025

2003
Eruptive xanthomas associated with olanzapine use.

Archives of dermatology| PubMed ID: 12925394

2003
Endothelial cell diversity revealed by global expression profiling.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 12963823

2003
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.

PLoS biology| PubMed ID: 14737219

2004
Kinetics and specificity of fas ligand induction in toxic epidermal necrolysis.

Archives of dermatology| PubMed ID: 14967808

2004
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 15701700

2005
The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.

FEBS letters| PubMed ID: 15878163

2005
Learning more from microarrays: insights from modules and networks.

The Journal of investigative dermatology| PubMed ID: 16098025

2005
Genetic regulators of large-scale transcriptional signatures in cancer.

Nature genetics| PubMed ID: 16518402

2006
From description to causality: mechanisms of gene expression signatures in cancer.

Cell cycle (Georgetown, Tex.)| PubMed ID: 16721055

2006
MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species.

Cancer research| PubMed ID: 16818632

2006
Current gut-directed therapies for irritable bowel syndrome.

Current treatment options in gastroenterology| PubMed ID: 16836950

2006
Anatomic demarcation by positional variation in fibroblast gene expression programs.

PLoS genetics| PubMed ID: 16895450

2006
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 17003113

2006
Predicting a local recurrence after breast-conserving therapy by gene expression profiling.

Breast cancer research : BCR| PubMed ID: 17069664

2006
Microarray analysis of stem cells and differentiation.

Methods in enzymology| PubMed ID: 17161699

2006
Patterning skin pigmentation via dickkopf.

The Journal of investigative dermatology| PubMed ID: 17435783

2007
Decoding global gene expression programs in liver cancer by noninvasive imaging.

Nature biotechnology| PubMed ID: 17515910

2007
Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs.

PLoS genetics| PubMed ID: 17542650

2007
A transcriptional program mediating entry into cellular quiescence.

PLoS genetics| PubMed ID: 17559306

2007
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.

Cell| PubMed ID: 17604720

2007
Turning skin into embryonic stem cells.

Nature medicine| PubMed ID: 17618266

2007
A histone H3 lysine 27 demethylase regulates animal posterior development.

Nature| PubMed ID: 17851529

2007
Motif module map reveals enforcement of aging by continual NF-kappaB activity.

Genes & development| PubMed ID: 18055696

2007
Revealing targeted therapy for human cancer by gene module maps.

Cancer research| PubMed ID: 18199530

2008
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.

Cancer research| PubMed ID: 18199546

2008
A dermal HOX transcriptional program regulates site-specific epidermal fate.

Genes & development| PubMed ID: 18245445

2008
Systematic functional characterization of cis-regulatory motifs in human core promoters.

Genome research| PubMed ID: 18256240

2008
Reversal of aging by NFkappaB blockade.

Cell cycle (Georgetown, Tex.)| PubMed ID: 18256548

2008
A systems biology approach to anatomic diversity of skin.

The Journal of investigative dermatology| PubMed ID: 18337710

2008
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

Nature| PubMed ID: 18337721

2008
Module map of stem cell genes guides creation of epithelial cancer stem cells.

Cell stem cell| PubMed ID: 18397753

2008
Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.

The Journal of clinical investigation| PubMed ID: 18414681

2008
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.

Genes & development| PubMed ID: 18628393

2008
Deletional tolerance mediated by extrathymic Aire-expressing cells.

Science (New York, N.Y.)| PubMed ID: 18687966

2008
Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification.

European journal of cancer (Oxford, England : 1990)| PubMed ID: 18715778

2008
Stemness, cancer and cancer stem cells.

Cell cycle (Georgetown, Tex.)| PubMed ID: 19029796

2008
Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes.

PloS one| PubMed ID: 19107207

2008
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Cell| PubMed ID: 19135889

2009
Molecular framework for response to imatinib mesylate in systemic sclerosis.

Arthritis and rheumatism| PubMed ID: 19180499

2009
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.

Molecular cell| PubMed ID: 19187765

2009
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

Cell stem cell| PubMed ID: 19200802

2009
Genome-wide views of chromatin structure.

Annual review of biochemistry| PubMed ID: 19317649

2009
Regeneration, repair and remembering identity: the three Rs of Hox gene expression.

Trends in cell biology| PubMed ID: 19428253

2009
Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression.

Cancer cell| PubMed ID: 19477427

2009
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.

Cancer cell| PubMed ID: 19477431

2009
Gene dates, parties and galas. Symposium on Chromatin Dynamics and Higher Order Organization.

EMBO reports| PubMed ID: 19525922

2009
HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells.

Stem cells (Dayton, Ohio)| PubMed ID: 19544454

2009
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19666525

2009
A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity.

The Journal of investigative dermatology| PubMed ID: 19812599

2010
Anatomic demarcation of cells: genes to patterns.

Science (New York, N.Y.)| PubMed ID: 19965461

2009
The histone demethylase UTX enables RB-dependent cell fate control.

Genes & development| PubMed ID: 20123895

2010
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis.

Nature| PubMed ID: 20393566

2010
Tumor suppression by the histone demethylase UTX.

Cell cycle (Georgetown, Tex.)| PubMed ID: 20505331

2010
Long noncoding RNA as modular scaffold of histone modification complexes.

Science (New York, N.Y.)| PubMed ID: 20616235

2010
Genome-wide measurement of RNA secondary structure in yeast.

Nature| PubMed ID: 20811459

2010
Long noncoding RNA in genome regulation: prospects and mechanisms.

RNA biology| PubMed ID: 20930520

2010
G1 arrest and differentiation can occur independently of Rb family function.

The Journal of cell biology| PubMed ID: 21059851

2010
Opioid-induced bowel dysfunction.

Current treatment options in gastroenterology| PubMed ID: 21063859

2008
Noncoding RNA landmarks of pluripotency and reprogramming.

Cell stem cell| PubMed ID: 21112559

2010
Long intergenic noncoding RNAs: new links in cancer progression.

Cancer research| PubMed ID: 21199792

2011
RNA templating the epigenome: long noncoding RNAs as molecular scaffolds.

Epigenetics : official journal of the DNA Methylation Society| PubMed ID: 21393997

2011
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.

Nature| PubMed ID: 21423168

2011
Long noncoding RNAs and human disease.

Trends in cell biology| PubMed ID: 21550244

2011
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters.

Nature genetics| PubMed ID: 21642992

2011
Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.

EMBO reports| PubMed ID: 21660059

2011
Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.

PLoS genetics| PubMed ID: 21738489

2011
Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival.

The Journal of clinical investigation| PubMed ID: 21821917

2011
Understanding the transcriptome through RNA structure.

Nature reviews. Genetics| PubMed ID: 21850044

2011
Molecular mechanisms of long noncoding RNAs.

Molecular cell| PubMed ID: 21925379

2011
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons.

Cell stem cell| PubMed ID: 21962918

2011
Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions.

Molecular cell| PubMed ID: 21963238

2011
Active chromatin and noncoding RNAs: an intimate relationship.

Current opinion in genetics & development| PubMed ID: 22154525

2011
A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells.

Stem cells and development| PubMed ID: 22236333

2012
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.

Cell| PubMed ID: 22265401

2012
Suppression of progenitor differentiation requires the long noncoding RNA ANCR.

Genes & development| PubMed ID: 22302877

2012